2018 Fiscal Year Final Research Report
Establishment of quantitative evaluation method of lymphatic transport function using in vivo imaging
| Project/Area Number |
15K21182
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
Cardiovascular surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Research Collaborator |
Kimata Yoshihiro
Yamada Kiyoshi
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Keywords | リンパ輸送機能 / 定量評価 |
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| Outline of Final Research Achievements |
To quantify function of lymphatic transportation, several conditions were examined by measuring remaining IRDye PEG as a fluorescent reagent injected at mouse hind limb using in vivo imaging over time, but no significant results were obtained. It was suggested the possibility that quantitative evaluation of lymphatic transportation can be performed by administering Fluorescent Dextran as a fluorescent reagent to the rat hind limb and measuring the fluorescence intensity of the blood sample collected over time to evaluate the amount of Fluorescent Dextran flowing into the blood along with the lymphatic flow.
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| Free Research Field |
リンパ学
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| Academic Significance and Societal Importance of the Research Achievements |
従来リンパ系の輸送機能を定量評価する検査が無かったが、新たな定量評価法の確立につながる結果が得られた。
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