Feasibility of sequence memory based on theta traveling waves in the hippocampus

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K21193
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Life / Health / Medical informatics; Soft computing
• Research Institution: Yamaguchi University
• Principal Investigator: Samura Toshikazu 山口大学, 大学院創成科学研究科, 准教授 (30566617)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 海馬 / CA3 / 時系列記憶 / シータリズム / 進行波 / ギャップ結合

Outline of Final Research Achievements

In this study, we examined the formation of sequence memory that are implemented on the spatiotemporal representation of a sequence by theta traveling waves in the hippocampus. Our computer simulation demonstrated that the hippocampal CA3 has a neural substrate for the input-dependent effective organization of neuronal activities in addition to the organization of unidirectionally propagating neuronal activities that correspond to theta traveling waves. These results indicate that the hippocampal CA3 has a capability to represent sequential information spatially. It is suggested that the formation of sequence memory from the spatiotemporal representation of a sequence is feasible in the hippocampus.

Free Research Field

計算論的神経科学