2016 Fiscal Year Final Research Report
Role of cardiac remodeling of novel peptide hormone INSL6
| Project/Area Number |
15K21201
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Cardiovascular medicine
Endocrinology
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
YOSHIDA Sumiko 徳島大学, 大学院医歯薬学研究部(医学系), 講師 (40510904)
|
|---|
| Research Collaborator |
AIHARA Ken-ichi
WALSH Kenneth
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 心臓リモデリング |
|---|
| Outline of Final Research Achievements |
We examined the role of INSL6 in the heart using INSL6 deficient mice (INSL6 KO). There was no difference in cardiac morphology between INSL6 KO mice and wild type mice under normal condition. INSL6 KO mice after angiotensin II stimulation showed significantly increased myocardial fibrosis and decreased cardiac function compared with wild type mice. It was suggested that INSL6 is involved in myocardial fibrosis and cardiac remodeling.
|
| Free Research Field |
生活習慣病
|
