Cardio-splenic interaction in atrial fibrillation with hypertension and diabetes

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K21245
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry; General physiology
• Research Institution: Oita University
• Principal Investigator: Kondo Hidekazu 大分大学, 医学部, 病院特任助教 (90724170)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 心房細動 / 圧負荷 / 脾臓 / インターロイキン10 / 線維化

Outline of Final Research Achievements

The role of the spleen in inflammatory atrial fibrosis induced by pressure overload is unknown. We investigated whether splenectomy (SPX) attenuates or exacerbates pressure overload-induced atrial inflammatory fibrosis and vulnerability to atrial fibrillation (AF) in rats. Male Sprague Dawley rats (6 weeks old) were divided into Sham+Sham, Sham+SPX, abdominal aortic constriction (AAC)+Sham, and AAC+SPX groups, and were evaluated for inflammation, fibrosis, and AF on days 2, 4, 14, and 28. (P<0.05). As a results, SPX exacerbates AAC-induced inflammatory atrial fibrosis and increases vulnerability to AF after 4 weeks, likely due to the depletion of spleen-derived IL-10.

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