2017 Fiscal Year Final Research Report
A fundamental study for construction of PDAC early diagnosis method by DNA methylation analysis.
| Project/Area Number |
15K21247
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
Experimental pathology
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| Research Institution | Kagoshima University |
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Principal Investigator |
Yokoyama Seiya 鹿児島大学, 医歯学域医学系, 助教 (20569941)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | PDAC / pancreas / MUC1 / MUC4 / prognosis / CA19-9 / DNA methylation / epigenetics |
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| Outline of Final Research Achievements |
Pancreatic ductal adenocarcinoma (PDAC) has high frequency of recurrence even if possible to surgery. In this program, we analyzed DNA methylation status of mucin genes using pancreatic tissue with/without tumor to construct marker for predicting prognosis after surgery. The methylation status of MUC1 and MUC4 are statistically associated with clinicopathological information. Our result suggested that MUC1 and MUC4 methylation status has potential for predicted prognosis.
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| Free Research Field |
実験病理学
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