Elucidation of the blood pressure adjustment mechanism using 3MST knockout mouse

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K21252
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery; Anesthesiology
• Research Institution: University of the Ryukyus
• Principal Investigator: Totsuka Yuichi 琉球大学, 医学部附属病院, 医員 (30747704)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 3MST / 高血圧 / 硫化水素

Outline of Final Research Achievements

It came to be known that hydrogen sulfide was gas with a wide variety of bioactivity including vasodilator action, cytoprotective property, inhibitory effect of ischemic reperfusion injury, anti-inflammatory action. We paid attention to one of the hydrogen sulfide synthase 3-Mercaptopyruvate(3MST) using 3MST-KO and WT mouse. We found that 3MST-KO mouse was hypertension. Cardiac output was comparable between both groups, whereas peripheral vascular resistance was increased in a group of 3MST-KO. There were plasma PGI2 decrease and urinary 8-isoprostane increase in 3MST-KO, and it was suggested that an oxidative stress increase was associated with a part for a mechanism of the vascular resistance increase.

Free Research Field

心臓血管外科