Functional Analysis of GPR143 in Pulmonary Hypertension

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K21271
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology; General pharmacology
• Research Institution: Yokohama City University
• Principal Investigator: KOGA Motokazu 横浜市立大学, 医学部, 助教 (00637233)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肺高血圧症 / L-DOPA / GPR143 / モノクロタリン

Outline of Final Research Achievements

We have been working that L-DOPA, a dopamine precursor has unique physiological activity. In 2017, Masukawa reported that L-DOPA receptor candidate, GPR-143, interact with alpha adrenergic receptor and modulating its action. Therefore, we have investigated at first that L-DOPA has any interaction to vasoconstriction of pulmonary artery. As a result we found that L-DOPA also enhance phenylephrine induced vasoconstriction in pulmonary artery. Moreover, interestingly, this action is attenuated in early stage of monocrotaline-induced pulmonary hypertensive rat model. This findings may yield novel pathological and therapeutic finding in pulmonary hypertension.

Free Research Field

薬理学／麻酔科学