2017 Fiscal Year Final Research Report
Functional analysis of interaction between DOPA and Glutamate neurotransmission in the nucleus tractus solitarii
| Project/Area Number |
15K21273
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
Neurochemistry/Neuropharmacology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | L-DOPA / Glutamate / GPR143 / 下位脳幹弧束核 |
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| Outline of Final Research Achievements |
Levodopa (DOPA) is currently the most used treatment for Parkinson's disease. We have hypothesis that DOPA is a neurotransmitter in the brain. In this study, we demonstrated that DOPA potentiates the action of glutamate in the nucleus tractus solitarii, which controls central blood pressure regulation.
We also identified the role of DOPA in cardiovascular regulation. We demonstrated that DOPA augments the action of the adrenergic α1 receptor through a DOPA receptor GPR143. It suggested that this mechanism may be involved in diurnal variation of blood pressure.
These findings indicate that DOPA plays an important role in physiological blood pressure control.
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| Free Research Field |
神経薬理学
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