The impact of gene-environmental interaction on head and neck cancer survival

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K21283
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology; Hygiene and public health
• Research Institution: Nagoya City University
• Principal Investigator: KAWAKITA Daisuke 名古屋市立大学, 大学院医学研究科, 研究員 (70584506)
• Research Collaborator: MATSUO Keitaro 愛知県がんセンター研究所, 遺伝子医療研部 ; HASEGAWA Yasuhisa 愛知県がんセンター, 中央病院頭頸部外科
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 頭頸部がん / 遺伝環境交互作用 / 飲酒 / アルデヒド脱水素酵素 / 予後

Outline of Final Research Achievements

We performed a retrospective cohort study of 267 head and neck squamous cell carcinoma (HNSCC) patients at Aichi Cancer Center. The prognostic value of pre-treatment drinking status and aldehyde dehydrogenase 2 (ALDH2) polymorphism was investigated using multivariate proportional hazard models.
Pretreatment drinking status and ALDH2 genotype was not significantly associated with survival in HNSCC patients. After stratification by ALDH2 genotype, we observed a significant positive dose-response relationship between drinking status and disease-free survival in HNSCC patients with ALDH2 Glu/Glu (Ptrend = 0.029).
To confirm this association, we should consider a drinking behavior change after treatment.

Free Research Field

頭頸部外科学