2017 Fiscal Year Final Research Report
Development of novel therapeutic agent using boron compound-modified PEG derivative for particle-beam radiation therapy (Boron Neutron Capture Therapy)
| Project/Area Number |
15K21327
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
Radiation science
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| Research Institution | Fukuyama University (2016-2017)
International University of Health and Welfare (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ホウ素中性子捕捉療法 / リポソーム |
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| Outline of Final Research Achievements |
As a low invasive treatment for the malignant tumors, boron neutron capture therapy is featured. This study focused on liposome and developed the novel boron cluster-modified PEG lipid derivative (PBL) that is able to deliver the 10B at high concentration in the tumor.
PBL could be modified to lipid film efficiently, and the liposome that prepared with it was low toxicity in vitro. And, the liposome succeeded in 20 ppm of boron concentration and above 5 of T/B ratio in 24 hours after administration to cancer-bearing mice. As a result, when irradiated neutron beam to it, the liposome showed a significant antitumor effect in comparison with each control group.
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| Free Research Field |
薬物送達学
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