2016 Fiscal Year Final Research Report
Studies on novel physiological functions of D-serine in nematode C. elegans
| Project/Area Number |
15K21361
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
Insect science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | D-セリン / 線虫 / 耐性幼虫 / L-セリンデヒドラターゼ |
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| Outline of Final Research Achievements |
D-Serine is an endogenous co-agonist for NMDA receptors and regulates neurotransmission and synaptic plasticity in the central nervous system. We have shown that D-serine is present in high concentration in dauer larva of nematode Caenorhabditis elegans, a multicellular model animal, and that D-serine is involved in several aspects of dauer development. We also found that one of mammalian serine racemase homologous genes is L-serine dehydratase and is involved indirectly in D-serine synthesis.
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| Free Research Field |
分子生物学、分析化学
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