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2017 Fiscal Year Final Research Report

Development of a novel diagnosis marker for kidney diseases by metabolome analysis

Research Project

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Project/Area Number 15K21364
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Kidney internal medicine
General physiology
Research InstitutionKeio University

Principal Investigator

HIRAYAMA Akiyoshi  慶應義塾大学, 政策・メディア研究科(藤沢), 特任講師 (00572405)

Research Collaborator MARUYAMA Shoichi  
AKIYAMA Shinichi  
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords腎疾患 / マーカー / CE-MS / 尿 / 血漿
Outline of Final Research Achievements

In this study, a comprehensive analysis of urine and plasma metabolites from nephrotic disease patients was conducted by capillary electrophoresis-mass spectrometry (CE-MS) in order to discover biomarkers specific to the type of disease. As a result, it was possible to create a model to distinguish from seven types of nephrotic diseases by combining two to five types of metabolites. With respect to unknown peaks, it was possible to perform a fractionation operation using LC-MS to identify new biomarker candidates.

Free Research Field

メタボロミクス

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Published: 2019-03-29  

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