2017 Fiscal Year Final Research Report
Development of new therapy of inflammatory diseases in parenchymal organs by fibrinolytic pathway
| Project/Area Number |
15K21373
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
Gastroenterology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HATTORI Koichi 東京大学, 大学院・医科学研究所, 特任准教授 (10360116)
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| Research Collaborator |
SAKAMOTO Kazuhiro 順天堂大学, 医学部, 教授 (60205763)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | Plasmin / 炎症性疾患 / MMP-9 / 線維素溶解系 |
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| Outline of Final Research Achievements |
We prepared a severe acute hepatitis mouse model, elucidated the role of fibrinolytic system, and developed new therapy.
In the pathogenesis of acute hepatitis, the activity of coagulation and fibrinolytic factors and the activation of various MMPs (matrix metalloproteinase) were revealed. Since pathological findings of acute hepatitis were improved in these gene - deficient mice, it was revealed that MMP activity accompanying enhancement of fibrinolytic system controls acute hepatitis pathology. By administering a novel drug YO-2 that inhibits the fibrinolytic factor plasmin, inflammatory cytokines are suppressed in acute hepatitis model mice, acute hepatitis can be controlled, and future clinical applications are expected .
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| Free Research Field |
消化器外科
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