Deformation of spherical nanoparticles to disk-shaped particles and their two-dimensional interactions for biomedical applications

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K21384
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering; Nanomaterials engineering
• Research Institution: Tokai University
• Principal Investigator: OKAMURA Yosuke 東海大学, 工学部, 准教授 (40365408)
• Research Collaborator: NAGASE Yu 東海大学, 工学部, 教授 (40155932) ; NAKAGAWA Atsushi 東海大学, マイクロナノ研究開発センター, 特定研究員 ; SOGABE Daiki 東海大学, 大学院工学研究科 ; ISHIKURA Kenichi 東海大学, 工学部応用化学科
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: ナノ粒子 / ディスク / 形状変換 / 接着性 / 薬剤放出特性 / 凝集反応

Outline of Final Research Achievements

Polymer particles with the diameters ranging from nanometer to micrometers are conventionally prepared by an emulsion of polymer solution and polymerization of monomer, etc. The obtained particles are contacted with the various surfaces and particles themselves via point-contact interactions due to the spherical shape. We herein propose a fabrication procedure of disk-shaped particles deformed by a hot-press technique, and their applications using two-dimensional interactions. The glass transition temperature of the polymers and the pressure at 10 MPa in hot-press process were important parameters to deform spheres to disks. Furthermore, we demonstrated that the unique properties of the disk-shaped particles were induced by their two-dimensional interactions, e.g. high adhesiveness to the surfaces, controlled release of encapsulating materials, and high aggregation between disks.

Free Research Field

生体材料学