Basic analysis of antibacterial photodynamic therapy using periodontal pathogenic bacterium uptake pigment

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K21454
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Periodontology; Pathobiological dentistry/Dental radiology
• Research Institution: Kanagawa Dental College
• Principal Investigator: YOSHIDA AYAKA 神奈川歯科大学, 大学院歯学研究科, 特別研究員 (00609414)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 青色光 / Prophyromonas gingivalis / 抗菌光線力学療法

Outline of Final Research Achievements

In recent years, the periodontitis treatment of antibacterial photodynamic therapy (aPDT) has attracted attention. The current method causes cytotoxicity by reactive oxygen species (ROS) induced by photoexcitation by dye staining. I investigated aPDT used for energy metabolism of periodontal pathogenic bacteria. It was examined that the effects of aPDT using pigment used for energy metabolism of periodontal pathogenic bacteria. It was recognized that bacterial peculiar pigment was excited and produced ROS by light irradiation. It caused bactericidal effect due to oxidation damage to DNA. According to this study, it was suggested that this aPDT has less influence on the living body than the method currently used and a possibility of a treatment method with high bactericidal effect against bacteria.

Free Research Field

医歯薬学