Identification and validation of gastric cancer genes

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K21470
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry; Tumor biology
• Research Institution: Kanazawa University (2016); Kanazawa Medical University (2015)
• Principal Investigator: Takeda Haruna 金沢大学, がん進展制御研究所, 助教 (80647975)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: がん / マウスモデル / 消化管 / 遺伝子

Outline of Final Research Achievements

We identified 1026 gastric candidate driver genes by genome-wide SB transposon mutagenesis screening in mice. Genes in Wnt signaling and TGF-beta signaling were frequently mutated, showing that SB-induced gastric tumors model human gastric cancers. Comparative analysis for candidate gastric cancer genes between human and mice enriched 258 genes. These genes are very likely to be potent candidate cancer genes in the stomach. Our result will help developing new therapeutic targets to cure gastric cancers.

Free Research Field

腫瘍生物学