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2016 Fiscal Year Final Research Report

Identification and validation of gastric cancer genes

Research Project

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Project/Area Number 15K21470
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Tumor biology
Research InstitutionKanazawa University (2016)
Kanazawa Medical University (2015)

Principal Investigator

Takeda Haruna  金沢大学, がん進展制御研究所, 助教 (80647975)

Project Period (FY) 2015-04-01 – 2017-03-31
Keywordsがん / マウスモデル / 消化管 / 遺伝子
Outline of Final Research Achievements

We identified 1026 gastric candidate driver genes by genome-wide SB transposon mutagenesis screening in mice. Genes in Wnt signaling and TGF-beta signaling were frequently mutated, showing that SB-induced gastric tumors model human gastric cancers. Comparative analysis for candidate gastric cancer genes between human and mice enriched 258 genes. These genes are very likely to be potent candidate cancer genes in the stomach. Our result will help developing new therapeutic targets to cure gastric cancers.

Free Research Field

腫瘍生物学

URL: 

Published: 2018-03-22  

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