2017 Fiscal Year Final Research Report
Molecular mechanisms and search for medication for increased alcohol drinking after adolescent chronic nicotine treatment
| Project/Area Number |
15K21542
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
Applied pharmacology
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| Research Institution | International University of Health and Welfare (2016-2017)
Kawasaki Medical School (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 喫煙 / アルコール依存症 / L 型カルシウムチャネル |
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| Outline of Final Research Achievements |
Nicotine and Ethanol (EtOH) have been frequently reported to be co-abused in humans. It is reported that smoker are more likely to be diagnosed with alcoholism than non-smokers. In this study, we investigated the involvement of L-type Cav1 channels in EtOH-induced place preference and EtOH intake using animals chronically treated with nicotine in adolescence. These results suggest that the facilitated EtOH-induced place preference and EtOH intake, when nicotine exposure history existed in adolescence, is due to up-regulated L-type Cav1.2 channels in dopamine D1 receptor-expressing nucleus accumbencs neurons.
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| Free Research Field |
神経薬理学
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