2016 Fiscal Year Final Research Report
The possiblity of resistance for anti-angiogenic therapy and therapeutic biomarker in tumor AMP-activated protein kinase
| Project/Area Number |
15K21555
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
Gastroenterology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 肝細胞癌 / 血管新生 / 血管新生抑制治療 |
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| Outline of Final Research Achievements |
The purpose of this study is to clarify whether energy metabolism is related to resistance for anti-angiogenic therapy. It is generally known that AMPK was activated when the cells falled into starved condition. We have found that AMPK was activated even in cancer cells by anti-angiogenic therapy. To know the function of tumor AMPK in anti-angiogenic therapy, we have generated AMPK deleted hepatoma cell lines. And we have performed in vitro and in vivo experiments using these cell lines. However, AMPK did not correlate with resistance for anti-angiogenic therapy. In contrast, inhibition of hypoxia inducible factor (HIF) showed significant anti-tumor effect for hepatocellular carcinoma.
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| Free Research Field |
肝細胞癌
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