"cancer vs. normal cells." Study on the role of tight junction in cell competition.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K21564
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including histology/embryology); Surgical dentistry
• Research Institution: Fukuoka Dental College
• Principal Investigator: Kitagawa Norio 福岡歯科大学, 口腔歯学部, 講師 (40628517)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 細胞競合 / 癌 / ケラチノサイト / 細胞骨格 / 抗菌ペプチド / Filamin / Vimentin / Cytokeratin 17

Outline of Final Research Achievements

To investigate the cell competition of normal keratinocytes versus cancer, a co-culture experimental system using several cancer cells and several normal cells were constructed. Expression of vimentin, a cytoskeleton, increased in a normal cell population surrounding a cancer cell population. This change was found not only in normal cells at the forefront of the cancer cell population but also in normal cells existing behind them. This change was induced by merely acting the culture supernatant of cancer cells.

Free Research Field

組織学