The involvement of cellular senescence in hepatic tumors that increase through multiple generations by gestational arsenite exposure

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K21611
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health; Risk sciences of radiation and chemicals
• Research Institution: National Institute for Environmental Studies
• Principal Investigator: Okamura Kazuyuki 国立研究開発法人国立環境研究所, 環境リスク・健康研究センター, 研究員 (50736064)
• Research Collaborator: Nohara Keiko 国立研究開発法人国立環境研究所, 環境リスク・健康研究センター, フェロー (50160271) ; Suzuki Takehiro 国立研究開発法人国立環境研究所, 環境リスク・健康研究センター, 主任研究員 (60425494)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ヒ素 / 多世代影響 / 細胞老化 / 酸化ストレス / Tgf-β / 妊娠期曝露

Outline of Final Research Achievements

Arsenite exposure has been known to induce liver cancer. Our previous study revealed that gestational arsenite exposure induced hepatic tumor increase in C3H F1 and F2 male mice, however, the mechanisms remain unknown. In this study, our data suggested that the gestational arsenite exposure-induced cellular senescence in F1 and F2 hepatic tumors via reduction of antioxidative enzymes and activation of Tgf-β pathway, respectively, are involved in hepatic tumor increase.

Free Research Field

環境毒性学