2017 Fiscal Year Final Research Report
Research on regulatory mechanism for oscillation and switch-like response of NF-kB
| Project/Area Number |
15K21624
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Life / Health / Medical informatics
System genome science
|
|---|
| Research Institution | University of Miyazaki (2016-2017)
Institute of Physical and Chemical Research (2015) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | シグナル伝達 / 数理モデリング / シミュレーション / NF-kB |
|---|
| Outline of Final Research Achievements |
Nuclear factor kappa B (NF-kB) is a transcription factor and is important for cell fate decision. The regulatory mechanism of NF-kB activation at molecular level is still unclear. We developed a mathematical model for NF-kB signal transduction system and focus on oscillatory behavior and switch-like response of NF-kB activity. Furthermore, we validated the results by biological experiments. The numerical and theoretical analysis showed that the mechanism of oscillatory behavior and switch-like response of NF-kB activity is not same but their behaviors can be interpolated by balance among amounts of molecules and reaction rates with respect to the activation. Our experiments supported the results.
|
| Free Research Field |
システム生物学
|
