Comprehensive identification of microRNAs that control atopic dermatitis using a gene regulatory network

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K21631
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: System genome science; Dermatology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Kawakami Eiryo 国立研究開発法人理化学研究所, 科学技術ハブ推進本部, 上級研究員 (30725338)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 遺伝子制御ネットワーク / 転写因子 / マイクロRNA / アトピー性皮膚炎 / Gene set enrichment解析

Outline of Final Research Achievements

The greatest result of this research is the development of wPGSA (weighted Parametric Gene Set Analysis) method which comprehensively predicts control factors from gene expression data taking stochastic control relationship into account (Kawakami et al. Nucleic Acids Research 2016). Prediction of transcriptional regulators by the wPGSA method is not limited to atopic dermatitis, but it has revealed the involvement of regulatory factors that have not been known until now in many life phenomena / diseases, and we are conducting joint research with more than 20 experimental groups.

Free Research Field

システム生物学