The relationship BCR signaling pathway and functional variants of TNFAIP3/A20

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K21647
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine; Hematology
• Research Institution: International University of Health and Welfare (2018); National Cancer Center Japan (2015-2017)
• Principal Investigator: Nomoto Junko 国際医療福祉大学, 医学部, 助手 (30601322)
• Research Collaborator: Kobayashi Yukio
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: TNFAIP3/A20 / BCRシグナル経路 / ターゲットシークエンス / ABC-DLBCL

Outline of Final Research Achievements

We performed target sequence analysis of ABC-type diffuse large-cell B-cell lymphoma (ABC-DLBCL). The genes of BCR signaling pathway downstream of BTK including NF-κB signaling pathway were analyzed. We found genes downstream from BTK, such as CARD11, and more downstream genes of NF-κB signaling pathway including TNFAIP3/A20 were mutated. These result suggested that the treatment of ABC-DLBCL by BTK inhibitor is not universally effective, especially in cases with mutated genes downstream of BTK.

Free Research Field

遺伝子検査学、ゲノム医学、造血器腫瘍

Academic Significance and Societal Importance of the Research Achievements

ABC-DLBCL の治療効果に関与する因子が同定され、それらが診断・治療選択・予後予測に有用であることを明らかにすることは、ABC-DLBCL のみならず、B 細胞性リンパ腫の新たな治療標的や治療法の開発、および診断や病型分類といった個別化医療の基盤となることが期待される。