Development of core-shell cell structure called CELL CAPSULE for myocardial tissue regeneration by using cell self-organization inducible surfaces

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K21693
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery; Biomedical engineering/Biomaterial science and engineering
• Research Institution: Okayama University of Science (2016); National Cardiovascular Center Research Institute (2015)
• Principal Investigator: IWAI Ryosuke 岡山理科大学, 付置研究所, 講師 (60611481)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 自己組織化 / スフェロイド / 再生医療 / 細胞工学 / DDS

Outline of Final Research Achievements

We have successfully prepared a novel cell aggregated construct having core-shell structure as we called “CELL CAPSULE” that contains therapeutic cells as core cells and support cells as shell cells by using our developed cell self-organization inducible culture surfaces. The core cells of CELL CAPSULE could reconstruct tissues within 3 weeks after their transplantation for outer surface of rat aorta. It is expected that aggressive regeneration of myocardial tissues could be achieved by the transplantation of CELL CAPSULE composed of cardiomyocytes as core cells and mesenchymal stem cells having anti-inflammatory and homing potential as shell cells.

Free Research Field

細胞工学