Creation of zipper-like molecules for inducing intercellular adhesion and analysis of intercellular interaction(Fostering Joint International Research)

2019 Fiscal Year Final Research Report

• Project/Area Number: 15KK0230
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: The University of Tokyo
• Principal Investigator: Teramura Yuji 東京大学, 大学院工学系研究科(工学部), 准教授 (10365421)
• Project Period (FY): 2016 – 2019
• Keywords: 細胞表面修飾 / 細胞移植 / 臓器移植 / PEG脂質

Outline of Final Research Achievements

In this Fostering Joint International Research, we aimed to establish cell-micro encapsulation methods to prevent immune rejection reactions based on technique using poly(ethylene glycol)-conjugated phospholipid (PEG-lipid). We successfully collaborated with Prof Bo Nilsson in Uppsala University (in Sweden), who has been working with clinical cell transplantation. In this study, we focused on the cellular surface modification to inhibit immune responses which occurred immediately after transplantation, and succeeded in the regulation with PEG-lipids.

Free Research Field

バイオマテリアル工学

Academic Significance and Societal Importance of the Research Achievements

糖尿病治療を目的とした膵ランゲルハンス島（膵島）移植、様々な疾患の治療に検討されている間葉系幹細胞（MSC）および腎疾患に対する腎臓移植では、移植直後の炎症反応が原因で、細胞傷害を受けるため、生着率が大きく低下する。そのため、本研究成果は、細胞移植や臓器移植の生着率の向上に大きく寄与するものである。