The pathophysiological mechanisms between treatment-resistance mood disorder and insulin resistance(Fostering Joint International Research)

2017 Fiscal Year Final Research Report

• Project/Area Number: 15KK0295
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Gunma University
• Principal Investigator: Narita Kosuke 群馬大学, 医学部附属病院, 講師 (70345677)
• Research Collaborator: Norhoff G Ottawa University, Mind and Brain Imaging, Research Chair
• Project Period (FY): 2015 – 2017
• Keywords: 治療抵抗性気分障害 / power-law exponent

Outline of Final Research Achievements

The scale-free dynamics of human brain activity, characterized by an elaborate temporal structure with scale-free properties, can be quantified using the power-law exponent (PLE) as an index. PLE modulation during cognitive-task-evoked activity and its relationship with an associated behavior remain unclear. We investigated PLE during both the resting state and task-evoked activities, as well as its relationship with behavior measured using mean reaction time (mRT) during the task, by fMRI. We found that face discrimination-induced BOLD signal changes in the medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), amygdala, and fusiform face area; PLE significantly decreased during task-evoked activity specifically in mPFC compared with resting state activity; most importantly, in mPFC, mRT significantly negatively correlated with both resting state PLE and the resting-task PLE difference.

Free Research Field

精神医学