Development of cell-penetrating peptides and their application to DDS carriers(Fostering Joint International Research)

2017 Fiscal Year Final Research Report

• Project/Area Number: 15KK0312
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research)
• Allocation Type: Multi-year Fund
• Research Field: Drug development chemistry
• Research Institution: Nagasaki University
• Principal Investigator: OBA Makoto 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (20396716)
• Research Collaborator: Huc Ivan European Institute for Chemistry and Biology, Group Leader
• Project Period (FY): 2015 – 2017
• Keywords: フォルダマー / 細胞膜透過性 / ヘリックス構造 / ドラッグデリバリー

Outline of Final Research Achievements

We designed and synthesized 8 hybrid foldamers composed of amino acids and quinoline derivatives. All hybrid foldamers adopted a right-handed helical structure independently of their structures of amino acids and quinoline derivatives. Cationic foldamers containing anionic amino acids formed aggregates and showed strong cell-penetrating ability compared to typical cell-penetrating peptide, Tat peptide. These findings will be helpful for design of de novo foldamers functioning as DDS carriers.

Free Research Field

ペプチド化学