2017 Fiscal Year Final Research Report
Overexpression of DDX27 in gastric cancer(Fostering Joint International Research)
| Project/Area Number |
15KK0351
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Oita University |
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Principal Investigator |
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| Research Collaborator |
CLEVERS Hans ヒュブレヒト研究所, クレバースグループ, グループリーダー
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| Project Period (FY) |
2016 – 2017
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| Keywords | オルガノイド |
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| Outline of Final Research Achievements |
Principal investigator collaborated with Clevers Group (Hubrecht Institute, the Netherlands), where a three dimensional culture method for intestinal organoids has been established in 2009 (Sato et al, Nature 2009). In this study, we established macroscopic intestinal tubes from small cystic organoids by using floating collagen gels. The organoids cultured in soft-floating collagen fused together via collagen gel contraction and formed continuous tube structure. We found that the tubes contain stem and most types of the differentiated intestinal cells. In future, the macroscopic tubes might be used as an in vitro model of intestinal epithelium in investigations, such as drug effects and regenerative medicine.
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| Free Research Field |
分子病理学
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