Exploring of the principle of epithelial tubulogenesis by intra- and extracellular small molecules

2017 Fiscal Year Final Research Report

• Project/Area Number: 15KT0154
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 特設分野
• Research Field: Constructive Systems Biology
• Research Institution: National Institute for Basic Biology
• Principal Investigator: SUZUKI MAKOTO 基礎生物学研究所, 形態形成研究部門, 助教 (10533193)
• Co-Investigator(Renkei-kenkyūsha): Ueno Naoto 基礎生物学研究所, 形態形成研究部門, 教授 (40221105) ; KOYAMA Hiroshi 基礎生物学研究所, 初期発生研究部門, 助教 (10530462) ; KATO Kagayaki 大学共同利用機関法人自然科学研究機構, 新分野創成センター, 特任助教 (30391915)
• Research Collaborator: YASUE Naoko
• Project Period (FY): 2015-07-10 – 2018-03-31
• Keywords: カルシウムイオン / 神経管形成 / 頂端収縮 / アフリカツメガエル

Outline of Final Research Achievements

In this study, we explored the function of intracellular calcium ions in epithelial morphogenesis by using the neural tube closure of the African clawed frog as a model. As a result, we developed the technique that induces one of the cellular movements necessary for epithelial sheet deformation, called apical constriction, and revealed the molecular mechanism of it. Moreover, we proposed the mechanical basis by which the synchrony of the apical constriction affects the efficiency of tissue deformation. The results of this study are expected to contribute to the understanding of the principle of morphogenesis of various epithelial organs as well as the neural tube.

Free Research Field

発生生物学