抗体遺伝子のクラススイッチおよび体細胞突然変異の機構の解明

Products Report

• Project/Area Number: 16043228
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: 新蔵 礼子 京都大学, 医学研究科, 助手 (50362471)
• Project Period (FY): 2004

Research Products

• [Journal Article] Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense. (2011)
  • Author(s): Wei M., et al.
  • Journal Title: Nature Immunology Volume: 12
  • DOI: 10.1038/ni.1991
  • Peer Reviewed
• [Journal Article] Separate domains of AID are required for somatic hypermutation and class switch recombination. (2004)
  • Author(s): Shinkura R., et al.
  • Journal Title: Nature Immunology Volume: 5 Pages: 707-712
  • Peer Reviewed
• [Presentation] Knock-in mice carrying a somatic hypermutation-defective Aicda mutation have impaired gut homeostasis and compromised mucosal defense. (2010)
  • Author(s): Shinkura R., et al.
  • Organizer: International Congress of Immunology
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-08-22
• [Presentation] AID domains defined from functional analyses using AID mutants. (2007)
  • Author(s): Shinkura R.
  • Organizer: FASEB Summer Research Conferences
  • Place of Presentation: Arizona, USA
  • Year and Date: 2007-07-00
  • Invited
• [Presentation] N-terminal region of activation-induced cytidine deaminase distinguishes downstream events for somatic hypermutation from gene conversion. (2006)
  • Author(s): Shinkura R.
  • Organizer: 20^<th> IUBMB International Congress of Biotechnology and Molecular Biology and 11^<th> FAOBMB
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2006-06-22
  • Invited
• [Presentation] Separate domains of AID are required for somatic hypermutation and class-switch recombination. (2004)
  • Author(s): Shinkura R., et al.
  • Organizer: International Congress of Immunology
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2004-08-00