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2008 Fiscal Year Annual Research Report

遺伝情報システム異常と発がん

Research Project

Project/Area Number 16059101
Research InstitutionJapanese Foundation For Cancer Research

Principal Investigator

野田 哲生  Japanese Foundation For Cancer Research, 所長 (10183550)

Keywords遺伝子 / ウイルス / 癌 / ゲノム / 細胞組織
Research Abstract

本研究領域は、「細胞のがん化とがんの進展の分子機構」を解明することによって、がんの予防・診断・治療に貢献することを目的として計画され、本総括班は、(1)研究推進と支援、(2)研究成果の公開と情報収集、などの活動を通じて研究班を統括し、円滑な領域運営を進めた。
領域運営と支援は、各総括班員が分担・協力して、領域全体および各項目の運営を行った。正副領域代表者の野田と石川は、領域全体の研究推進を統括すると同時に、「統合がん」総括班会議や、がん特定研究正副領域代表者会議に出席することにより、「がん特定」他領域との緊密な連携を進めた。研究項目長は、各項目の研究推進を統括し、そのための助言・指導や情報収集を行って来た。その他の、本研究分野で顕著な業績を持つ総括班員は、主として研究計画実施の方針に対する助言を担当した。本年度は、本特定研究領域の第二回目の中間評価の翌年に当たっており、本総括班が中心となって成果の取りまとめを行い、これを基に「平成20年度成果状況報告書」を作成し、文部科学省に提出した。具体的には、全ての計画・公募班員より、成果報告書を提出して頂いた上で、各項目長が担当領域の成果状況の評価を行ない、この結果を領域代表が取りまとめて、報告書を作成した。
本総括班は、平成20年7月4日には、東京ステーションカンファレンスにおいて、がん特定研究の他領域と合同で、研究代表者会議を開催し、研究者間の情報交換の促進を行ない、さらに、平成21年2月2-3日の二日間に亘って、がん特定5領域合同シンポジウムを開催した。本シンポジウムには、本領域の班員の多くが参加し、さらに3名の計画班員が成果の発表を行い、研究交流と情報交換に努めた。

  • Research Products

    (21 results)

All 2009 2008 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Remarks (1 results)

  • [Journal Article] PRMT5, a novel TRAIL receptor-binding protein, inhibits TRAIL-induced apoptosis via Nuclear Factor-B activation.2009

    • Author(s)
      H. Tanaka, T. Noda, et. al. (total 9, 6th)
    • Journal Title

      Mol. Cancer Res. 7

      Pages: 557-569

    • Peer Reviewed
  • [Journal Article] Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways.2009

    • Author(s)
      T. Watanabe, T. Noda, et. al. (total 19, 14th)
    • Journal Title

      J. Biol. Chem. 284

      Pages: 1803-1812

    • Peer Reviewed
  • [Journal Article] Kinetochore stretching inactivates the spindle assembly checkpoint.2009

    • Author(s)
      K. S. Uchida, T. Noda, et. al. (total 6, 5th)
    • Journal Title

      J. Cell Biol. 184

      Pages: 383-390

    • Peer Reviewed
  • [Journal Article] An essential role of the universal polarity protein, aPKC1ambda, on the maintenance of podocyte slit diaphragms.2009

    • Author(s)
      T. Hirose, T. Noda, et. al. (total 1O, 9th)
    • Journal Title

      PLoS ONE 4

      Pages: e4194

    • Peer Reviewed
  • [Journal Article] PDK1 coordinates survival pathways and {beta}-adrenergic response in the heart.2009

    • Author(s)
      K. Ito, T. Noda, et. al. (total 15, 13th)
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Pages: (in press)

    • Peer Reviewed
  • [Journal Article] PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles.2009

    • Author(s)
      P. Reddy, T. Noda, et. al. (tota111,8th)
    • Journal Title

      Hum. Mol. Genet.

      Pages: (in press)

    • Peer Reviewed
  • [Journal Article] Megaintestine in claudin-15-deficient mice.2008

    • Author(s)
      A. Tamura, T. Noda, et. al. (total 12, 9th)
    • Journal Title

      Gastroenterology 134

      Pages: 523-534

    • Peer Reviewed
  • [Journal Article] GTAssist : An evaluation tool for efficient selection of SNP markersin large-scale genotyping.2008

    • Author(s)
      E. Kaminuma, T. Noda, et. al.(total 12, 9th)
    • Journal Title

      J. Bioinform. Comput. Biol. 6

      Pages: 905-917

    • Peer Reviewed
  • [Journal Article] Biphasic response of pancreatic beta-cell mass to ablation of TSC2 in mice.2008

    • Author(s)
      Y. Shigeyama, T. Noda, et. al. (total 15, 15th)
    • Journal Title

      Mol. Cell. Biol. 28

      Pages: 2971-2979

    • Peer Reviewed
  • [Journal Article] Osteoporptic bone formation in mice lacking tob2 ; involvement of Tob2 in RANK Iigand expression and osteoclasts differentiation.2008

    • Author(s)
      A. Ajima, T. Noba, et. al. (total 11, 10th)
    • Journal Title

      FEBS Lett. 582

      Pages: 1313-1318

    • Peer Reviewed
  • [Journal Article] Deficiency of Z0-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apotosis of embryonic cells.2008

    • Author(s)
      T. Katsuno, T. Noda, et. al. (total 12, 10th)
    • Journal Title

      Mol. Biol. Cell 19

      Pages: 2465-2475

    • Peer Reviewed
  • [Journal Article] Molecular mechanism of moderate insulin resistance in adiponectin-knockout mice.2008

    • Author(s)
      W. Yano, T. Noda, et. al.(total 14, 11th)
    • Journal Title

      Endocr. J. 55

      Pages: 515-522

    • Peer Reviewed
  • [Journal Article] PDKl regulates cell proliferation and cell cycle progression through control of cyclin Dl and p27Kipl expression.2008

    • Author(s)
      K. Nakamura, T. Noda, et. al.(total 12, 10th)
    • Journal Title

      J. Biol. Chem. 283

      Pages: 17702-17711

    • Peer Reviewed
  • [Journal Article] Dynamic functional relay between insulin receptor substrate 1 and 2 in hapatic insulin sighaling during fasting and feeding.2008

    • Author(s)
      N. Kubota, T. Noda, et. al. (total 21, 15th)
    • Journal Title

      Cell Metab. 8

      Pages: 49-64

    • Peer Reviewed
  • [Journal Article] HOXB2, an adverse prognostic indicator for stage I lung adenocarcinomas, promotes invasion by transcriptional regulation of metastasis-related genes in HOP-62 non-small cell lung cancer cells.2008

    • Author(s)
      H. Inamura, T. Noda, et. al. (total 6, 5th)
    • Journal Title

      Anticancer Res. 28

      Pages: 2121-2128

    • Peer Reviewed
  • [Journal Article] IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis.2008

    • Author(s)
      M. Isomura, T. Noda, et. al. (total 20, 9th)
    • Journal Title

      Clin. Cancer Res. 14

      Pages: 6683-6689

    • Peer Reviewed
  • [Journal Article] Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin.2008

    • Author(s)
      Y. Dohi, T. Noda, et. al. (total 13, 12th)
    • Journal Title

      Nat. Struct. Mol. Biol. 15

      Pages: 1246-1254

    • Peer Reviewed
  • [Journal Article] Identification and characterization of new long conserved noncoding sequences in vertebrates.2008

    • Author(s)
      Y. Sakuraba, T. Noda, et. al. (total 15, 13th)
    • Journal Title

      Mamm. Genome 19

      Pages: 703-712

    • Peer Reviewed
  • [Journal Article] Pancreatic beta cell mass preserved in heterozygous PDK1 knockout mice.2008

    • Author(s)
      A. Takeda, T. Noda, et. al. (total 6, 5th)
    • Journal Title

      Kobe J. Med. Sci. 54

      Pages: E183-190

    • Peer Reviewed
  • [Journal Article] Role of ASC in the mouse model of Helicobacter pylori infection.2008

    • Author(s)
      B. N. Benoit, T. Noda, et. al. (total 12, 9th)
    • Journal Title

      J. Histochem. Cytochem. 57

      Pages: 327-338

    • Peer Reviewed
  • [Remarks]

    • URL

      http://gantoku3.umin.jp/index.html

URL: 

Published: 2010-06-11   Modified: 2016-04-21  

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