Diagnosis, Epidemiology, and Chemoprevention of Cancer

2009 Fiscal Year Final Research Report

• Project/Area Number: 16061101
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: NAKAMURA Yusuke The University of Tokyo, 医科学研究所, 教授 (70217909)
• Co-Investigator(Renkei-kenkyūsha): INAZAWA Johji 東京医科歯科大学, 難治疾患研究所, 教授 (30193551) ; HAMAJIMA Nobuyuki 名古屋大学, 大学院・医学系研究科, 教授 (30172969) ; ABURATANI Hiroyuki 東京大学, 先端科学技術研究センター, 教授 (10202657) ; UEDA Ryuzo 名古屋市立大学, 大学院・医学研究科, 教授 (20142169) ; TAKAHASHI Takashi 名古屋大学, 大学院・医学系研究科, 教授 (50231395) ; TAJIMA Kazuo 愛知県がんセンター, 研究所, 所長 (30150212) ; TSUGANE Shoichiro 国立がん研究センター, 予防研究部, 部長 (40179982) ; MIYAZONO Kohei 東京大学, 大学院・医学系研究科, 教授 (90209908)
• Project Period (FY): 2004 – 2009
• Keywords: オーダーメイド医療 / 分子標的 / 民族疫学 / プロテオミクス / 化学予防 / SNP

Research Abstract

To investigate genetic factors and establish the policy how to prevent cancer, we constructed a large cohort study by participation of multi centers in Japan. By March 31, 2010, we have enrolled nearly 48,000 individuals from nine locations in Japan and have been seeking the genetic factors and environment factors, and also investigating their interactions. In addition, we have performed systematic genomics and proteomics analysis to investigate genes involved in development and progression of cancer. Through the genome-wide expression profile analysis and genome-wide association analysis using SNPs, we identified genes susceptible to cancers and those characterizing individual caners. Such information can be applied for the establishment of personalized medicine. Furthermore, through molecular epidemiological approaches in which we compared the differences between Japanese population and other Asian populations, we attempted to identify the factors that make differences in the cancer incidence among these countries.

Research Products

• [Journal Article] Novel lipogenic enzyme ELOVL7 involves in prostate cancer growth through saturated long-chain fatty acid metabolism. (2009)
  • Author(s): K. Tamura, A. Makino, F. Hullin-Masuda, T. Kobayashi, M. Furihata, S. Chung, S. Ashida, T. Miki, T. Fujioka, T. Shuin, Y. Nakamura, H. Nakagawa
  • Journal Title: Cancer Research 69 Pages: 8133-8140
• [Journal Article] Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells. (2009)
  • Author(s): T. Ueki, J. -H. Park, T. Nishidate, K. Kijima, K. Hirata, Y. Nakamura, T. Katagiri
  • Journal Title: Cancer Research 69 Pages: 8752-8760
• [Journal Article] Identification of Nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer. (2009)
  • Author(s): A. Takano, N. Ishikawa, R. Nishino, K. Masuda, W. Yasui, K. Inai, H. Nishimura, H. Ito, H. Nakayama, Y. Miyagi, E. Tsuchiya, N. Kohno, Y. Nakamura, Y. Daigo
  • Journal Title: Cancer Research 69 Pages: 6694-6703
• [Journal Article] A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. (2009)
  • Author(s): Y. Kamatani, S. Wattanapokayakit, H. Ochi, T. Kawaguchi, A. Takahashi, N. Hosono, M. Kubo, T. Tsunoda, N. Kamatani, H. Kumada, A. Puseenam, T. Sura, Y. Daigo, K. Chayama, W. Chantratita, Y. Nakamura, K. Matsuda
  • Journal Title: Nature Genetics 41 Pages: 591-595
• [Journal Article] Overexpression of cysteine proteinase inhibitor cystatin 6 promotes pancreatic cancer growth. (2008)
  • Author(s): M. Hosokawa, K. Kashiwaya, M. Furihara, H. Eguchi, H. Ohigashi, O. Ishikawa, Y. Shinomura, K. Imai, Y. Nakamura, H. Nakagawa
  • Journal Title: Cancer Science 99 Pages: 1626-1632
• [Journal Article] Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10. (2008)
  • Author(s): C. Fukukawa, H. Hanaoka, S. Nagayama, T. Tsunoda, J. Toguchida, K. Endo, Y. Nakamura, T. Katagiri
  • Journal Title: Cancer Science 99 Pages: 432-440
• [Journal Article] Involvement of KIF2C/MCAK overexpression in mammary carcinogenesis. (2008)
  • Author(s): A. Shimo, C. Tanikawa, T. Nishidate, K. Matsuda, M. -L. Lin, J. -H. Park, T. Ohta, K. Hirata, M. Fukuda, Y. Nakamura, T. Katagiri
  • Journal Title: Cancer Science 99 Pages: 62-70
• [Journal Article] Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer. (2007)
  • Author(s): M. Kanehira, T. Katagiri, A. Shimo, R. Takata, T. Shuin, T. Miki, T. Fujioka, Y. Nakamura
  • Journal Title: Cancer Research 67 Pages: 3276-3285
• [Journal Article] Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas. (2007)
  • Author(s): T. Yamabuki, A. Takano, S. Hayama, N. Ishikawa, T. Kato, M. Miyamoto, T. Ito, H. Ito, Y. Miyagi, H. Nakayama, M. Fujita, M. Hosokawa, E. Tsuchiya, N. Kohno, S. Kondo, Y. Nakamura, Y. Daigo
  • Journal Title: Cancer Research 67 Pages: 2517-2525
• [Journal Article] Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas. (2007)
  • Author(s): N. Ishikawa, A. Takano, W. Yasui, K. Inai, H. Nishimura, H. Ito, Y. Miyagi, H. Nakayama, M. Fujita, M. Hosokawa, E. Tsuchiya, N. Kohno, Y. Nakamura, Y. Daigo
  • Journal Title: Cancer Research 67 Pages: 11601-11611
• [Journal Article] PDZ-binding kinase/T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer. (2006)
  • Author(s): J. -H. Park, M. -l. Lin, T. Nishidate, Y. Nakamura, T. Katagiri
  • Journal Title: Cancer Research 66 Pages: 9186-9195
• [Journal Article] Enhanced SMYD3 expression is essential for the growth of breast cancer cells. (2006)
  • Author(s): R. Hamamoto, F.P. Silva, M. Tsuge, T. Nishidate, T. Katagiri, Y. Nakamura, Y. Furukawa
  • Journal Title: Cancer Science 97 Pages: 113-118
• [Journal Article] A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers. (2005)
  • Author(s): M. Tsuge, R. Hamamoto, F.P. Silva, Y. Ohnishi, K. Chayama, N. Kamatani, Y. Furukawa, Y. Nakamura
  • Journal Title: Nature Genetics 37 Pages: 1104-1107
• [Journal Article] Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer. (2005)
  • Author(s): C. Furukawa, Y. Daigo, N. Ishikawa, T. Kato, T. Ito, E. Tsuchiya, S. Sone, Y. Nakamura
  • Journal Title: Cancer Research 65 Pages: 7102-7110
• [Presentation] From cancer genomics to cancer treatment (2010)
  • Author(s): 中村祐輔
  • Organizer: 8th Joint Coference of the American Association for Cancer Research and the Japanese Cancer Association.
  • Place of Presentation: Waikoloa, Hawaii, USA
  • Year and Date: 2010-02-05
• [Presentation] がんゲノム研究からトランスレーショナルリサーチへ (2008)
  • Author(s): 中村祐輔
  • Organizer: 第67回日本癌学会学術総会・第46回日本癌治療学会合同企画
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-30
• [Presentation] がんゲノム研究からがん分子標的治療薬開発に向けて (2007)
  • Author(s): 中村祐輔
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-04
• [Presentation] From cancer genomics to cancer clinic (2006)
  • Author(s): 中村祐輔
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2006-09-29
• [Presentation] 個別化治療の現状と展望 (2005)
  • Author(s): 中村祐輔
  • Organizer: 第64回日本癌学会学術総会
  • Place of Presentation: 北海道厚生年金会館
  • Year and Date: 2005-09-14