Molecular Basis of the Structure and Function of the Brain

2009 Fiscal Year Final Research Report

• Project/Area Number: 16070101
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: MISHINA Masayoshi The University of Tokyo, 大学院・医学系研究科, 教授 (80144351)
• Co-Investigator(Renkei-kenkyūsha): MASU Masayuki 筑波大学, 大学院・人間総合科学研究所, 教授 (20243032) ; YAMAMORI Tetsuo 自然科学研究機構, 基礎生物学研究所, 教授 (80260206) ; NODA Makoto 京都大学, 大学院・医学研究科, 教授 (30146708) ; NOSE Akinao 東京大学, 大学院・新領域創成科学研究科, 教授 (30260037)
• Project Period (FY): 2004 – 2010
• Keywords: 分子 / 神経幹細胞 / 神経回路網 / 脳発達 / 神経細胞機能 / 脳高次機能 / 統合研究 / 分子脳科学

Research Abstract

Integrative molecular approaches to the structure and function of the brain revealed the molecular mechanisms of the brain development from the development of neural stem cells to the neural network formation. Furthermore, functions of neurons have been studied at the levels of molecular network, neural network and brain systems. Finally, we established integrative molecular brain sciences and investigated the molecular basis of higher brain functions. These achievements were reported in many academic journals and presses.

Research Products

• [Journal Article] Molecular mechanisms underlying neural circuit formation. (2009)
  • Author(s): Lu, B., Wang K.H., Nose, A
  • Journal Title: Curr. Opin. Neurobiol. 19 Pages: 162-167
  • Peer Reviewed
• [Journal Article] Target recognition at the tips of postsynaptic filopodia: accumulation and function of Capricious. (2009)
  • Author(s): Kohsaka, H, Nose, A
  • Journal Title: Development 136 Pages: 1127-1135
  • Peer Reviewed
• [Journal Article] Reck forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin. (2009)
  • Author(s): Omura A, Matsuzaki T, Mio K, Ogura T, Yamamoto M, Fujita A, Okawa K, Kitayama H, Takahashi C, Sato C, Noda M.
  • Journal Title: J Biol Chem 284 Pages: 3461-3469
  • Peer Reviewed
• [Journal Article] Differential Expression Patterns of occ1-Related Genes in Adult Monkey Visual Cortex. (2009)
  • Author(s): Takahata, T., Komatsu, Y., Watakabe, A., Hashikawa, T., Tochitani, S., Yamamori, T.
  • Journal Title: Cereb Cortex. 19 Pages: 1937-1951
  • Peer Reviewed
• [Journal Article] Paraneoplastic Antigen-Like 5 Gene (PNMA5) Is Preferentially Expressed in the Association Areas in a Primate Specific Manner. (2009)
  • Author(s): Takaji, M., Komatsu, Y., Watakabe, A., Hashikawa, T., Yamamori, T.
  • Journal Title: Cereb Cortex. 19 Pages: 2865-2879
  • Peer Reviewed
• [Journal Article] Expression of immediate-early genes reveals functional compartments within ocular dominance columns after brief monocular inactivation. (2009)
  • Author(s): Takahata T, Higo N, Kaas J.H., Yamamori, T.
  • Journal Title: Proc Natl Acad Sci U S A. 106 Pages: 12151-12155
  • Peer Reviewed
• [Journal Article] A novel form of memory for auditory fear conditioning at a low-intensity unconditioned stimulus. (2009)
  • Author(s): Kishioka, A., Fukushima, F., Ito, T., Kataoka, H., Mori, H., Ikeda, T., Itohara, S., Sakimura, K., Mishina, M.
  • Journal Title: PLoS ONE 4 Pages: 4157
  • Peer Reviewed
• [Journal Article] Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking Delphilin. (2008)
  • Author(s): Takeuchi, T., Ohtsuki, G., Yoshida, T., Fukaya, M., Wainai, T., Yamashita, M., Yamazaki, Y., Mori, H., Sakimura, K., Kawamoto, S., Watanabe, M., Hirano, T., Mishina, M
  • Journal Title: PLoS ONE 3 Pages: 2297
  • Peer Reviewed
• [Journal Article] Wnt4 is a local repulsive cue that determines synaptic target specificity. (2007)
  • Author(s): Inaki, M., Yoshikawa, S., Thomas, J.B., Aburatani, H., Nose, A
  • Journal Title: Curr. Biol 17 Pages: 1574-1579
  • Peer Reviewed
• [Journal Article] In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2. (2007)
  • Author(s): Kohsaka, H., Takasu, E., Nose, A.
  • Journal Title: J. Cell Biol. 179 Pages: 1289-1300
  • Peer Reviewed
• [Journal Article] Migration and nucleogenesis of mouse precerebellar neurons visualized by in utero electroporation of a green fluorescent protein gene. (2007)
  • Author(s): Okada, T., Keino-Masu, K., Masu, M.
  • Journal Title: Neurosci. Res 57 Pages: 40-49
  • Peer Reviewed
• [Journal Article] Sept4, a component of presynaptic scaffold and lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. (2007)
  • Author(s): Ihara M, Yamasaki N, Hagiwara A, Tanigaki A, Kitano A, Hikawa R, Tomimoto H, Noda M, Takanashi M, Mori H, Hattori N, Miyakawa T, Kinoshita M.
  • Journal Title: Neuron 53 Pages: 519-533
  • Peer Reviewed
• [Journal Article] Reck modulates notch signaling during cortical neurogenesis by regulating adam10 activity. (2007)
  • Author(s): Muraguchi T, Takegami Y, Ohtsuka T, Kitajima S, Chandana EP, Omura A, Miki T, Takahashi R, Matsumoto N, Ludwig A, Noda M, Takahashi C.
  • Journal Title: Nat Neurosci 10 Pages: 838-845
• [Journal Article] Regulation of long-term depression and climbing fiber territory by glutamate receptor δ2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells. (2007)
  • Author(s): Uemura, T., Kakizawa, S., Yamasaki, M., Sakimura, K., Watanabe, M., Iino, M., Mishina, M.
  • Journal Title: J. Neurosci. 27 Pages: 12096-12108
  • Peer Reviewed
• [Journal Article] Conditional gene targeting on the pure C57BL/6 genetic background. (2007)
  • Author(s): Mishina, M., Sakimura, K
  • Journal Title: Neurosci. Res. 58 Pages: 105-112
  • Peer Reviewed
• [Journal Article] Regulation of layer-specific targeting by reciprocal expression of a cell adhesion molecule (2006)
  • Author(s): Shinza-Kameda, M., Takasu, E., Sakurai, K., Hayashi, S., Nose, A.
  • Journal Title: Capricious. Neuron 49 Pages: 205-213
  • Peer Reviewed
• [Journal Article] Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling. (2006)
  • Author(s): Kamimura, K., Koyama, T., Habuchi, H., Ueda, R., Masu, M., Kimata, K., Nakato, H
  • Journal Title: J. Cell Biol. 174 Pages: 773-778
  • Peer Reviewed
• [Journal Article] Expression of a heparan sulfate remodeling enzyme, heparan sulfate 6-O-endosulfatase sulfatase FP2, in the rat nervous system. (2005)
  • Author(s): Nagamine, S., Koike, S., Keino-Masu, K., Masu, M.
  • Journal Title: Brain Res. Dev. Brain Res. 159 Pages: 135-143
  • Peer Reviewed
• [Journal Article] Control of synaptic connection by glutamate receptor δ2 in the adult cerebellum. (2005)
  • Author(s): Takeuchi, T., Miyazaki, T., Watanabe, M., Mori, H., Sakimura, K., Mishina, M.
  • Journal Title: J. Neurosci. 25 Pages: 2146-2156
  • Peer Reviewed
• [Journal Article] Trans-synaptic interaction of GluRδ2 and neurexin through Cbln1 mediates synapse formation in the cerebellum.
  • Author(s): Uemura, T., Lee, S., Yasumura, M., Takeuchi, T., Yoshida, T., Ra, M., Taguchi, R., Sakimura, K., Mishina, M.
  • Journal Title: Cell (in press)
  • Peer Reviewed
• [Book] 神経の分化, 回路形成, 機能発現 (2008)
  • Author(s): 三品昌美, 他
  • Total Pages: 297-595
  • Publisher: 共立出版
• [Remarks] ホームページ統合脳プラットフォーム
  • URL: http://ibr.neuroinf.jp/