2008 Fiscal Year Final Research Report
Studies on sex chromosomal structures and function of sexual differentiation-related genes in animals with unknown sex-determining systems
| Project/Area Number |
16086201
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
MATSUDA Youichi Hokkaido University, 大学院理学研究院, 教授 (70165835)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUROIWA Asato 北海道大学, 大学院理学研究院, 講師 (20372261)
NISHIDA Chizuko 北海道大学, 大学院理学研究院, 助手 (50106580)
|
|---|
| Project Period (FY) |
2004 – 2008
|
| Keywords | 性染色体 / 性決定 / 性分化 / 脊椎動物 / 多様性 / 進化 |
|---|
| Research Abstract |
両生類から哺乳類までの多岐にわたる脊椎動物を対象として、性染色体の起源とその進化メカニズムを明らかにし、性決定機構が不明な動物の性決定遺伝子を探索・同定することを目標に研究を実施した。その結果、爬虫類、鳥類、哺乳類がもつ性染色体は、共通祖先が持っていた異なる常染色体から分化したこと明らかにした。また、両生類と爬虫類は、同じ綱や目内でも性染色体の起源が多様であることが明らかにした。また、多種の鳥類の性染色体の構造比較によって性染色体の分化メカニズムとそのプロセスを明らかにした。また、鳥類の性腺分化に関わる新規遺伝子を複数同定し、また、Y染色体を消失したトゲネズミから、Sry遺伝子に換わる新たな性決定候補遺伝子を同定した。
|
-
-
-
-
-
-
-
-
-
[Journal Article] DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes2008
Author(s)
Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Totoki Y, Toyoda A, Ikawa M, Asada N, Kojima K, Yamaguchi Y, Ijiri TW, Hata K, Li E, Matsuda Y, Kimura T, Okabe M, Sakaki Y, Sasaki H and Nakano T
-
Journal Title
Genes Dev 22
Pages: 908-917
Peer Reviewed
-
-
[Journal Article] A W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis2008
Author(s)
Yoshimoto S, Okada E, Umemoto H, Tamura K, Uno Y, Nishida-Umehara C, Matsuda Y, Takamatsu N, Shiba T and Ito M
-
Journal Title
Proc. Natl. Acad. Sci. USA 105
Pages: 2469-2474
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Highly conserved linkage homology between birds and turtles : Birds and turtle chromosomes are precise counterparts of each other2005
Author(s)
Matsuda Y, Nishida-Umehara C, Tarui H, Kuroiwa A, Yamada K, Isobe T, Ando J, Fujiwara A, Hirao Y, Nishimura O, Ishijima J, Hayashi A, Saito T, Murakami T, Murakami Y, Kuratani S and Agata K
-
Journal Title
Chromosome Res 13
Pages: 601-615
Peer Reviewed
-
-
[Journal Article] Structural and functional analysis of a 0.5-Mb chicken region orthologous to the imprinted mammalian Ascl2/Mash2-Igf2-H19 region2005
Author(s)
Yokomine T, Shirohzu H, Purbowasito W, Toyoda A, Iwama H, Ikeo K, Hori T, Mizuno S, Tsudzuki M, Matsuda Y, Hattori M, Sakaki Y and Sasaki H
-
Journal Title
Genome Res 15
Pages: 154-165
Peer Reviewed
-
-
-
-
-
[Journal Article] Ferguson-Smith MA, Crooijmans RPMA, Groenen MAM and Griffin DK. Molecular cytogenetic definition of the chicken genome : the first complete avian karyotype2004
Author(s)
Masabanda JS, Burt DW, O'Brien PC, Vignal A, Fillon V, Walsh PS, Cox H, Tempest HG, Smith J, Habermann F, Schmid M, Matsuda Y
-
Journal Title
Genetics 166
Pages: 1367-1373
Peer Reviewed
-
-
[Journal Article] Mili, a mammalian member of piwi family gene, is essential for spermatogenesis2004
Author(s)
Kuramochi-Miyagawa S, Kimura T, Ijiri TW, Isobe T, Asada N, Fujita Y, Ikawa M, Iwai N, Okabe M, Deng W, Lin H, Matsuda Y and Nakano T
-
Journal Title
Development 131
Pages: 839-849
Peer Reviewed
-
-
-
-
-
-
[Presentation] Karyotypic evolution in snakes2008
Author(s)
Matsubara K, Tarui H, Toriba M, Kumazawa Y, Ota H, Yamada K, Nishida C, Agata K and Matsuda Y
Organizer
The 3rd Asian Chromosome Colloquium 2008
Place of Presentation
Osaka
Year and Date
20081201-04
-
-
[Presentation] Molecular cytogenetic approach to a Y-loss event in Ryukyu spiny rat (genus Tokudaia, Muridae, Rodentia)2008
Author(s)
Murata C, Yamada F, Kawauchi N, Miyake Y, Fukuchi S, Shichiri H, Abe S, Kotaka N, Matsuda, Y, Kuroiwa A
Organizer
The 3rd Asian Chromosome Colloquium
Place of Presentation
Osaka
Year and Date
20081201-04
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
