2008 Fiscal Year Final Research Report
The molecular mechanisms of sex diffrentiation by nuclear hormone receptors
Project/Area Number |
16086205
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | The University of Tokyo |
Principal Investigator |
TAKEYAMA Ken-ichi The University of Tokyo, 分子細胞生物学研究所, 講師 (30323570)
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Co-Investigator(Kenkyū-buntansha) |
TAKADA Ichiro 東京大学, 分子細胞生物学研究所, 助教授 (50361655)
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Project Period (FY) |
2004 – 2008
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Keywords | 性ステロイドホルモン / アンドロゲン / エストロゲン / 転写制御 / 核内受容体 |
Research Abstract |
本研究は性ホルモンの性分化作用機構を分子レベルで解明するため、性ホルモン受容体を介した転写制御機構に着目し解析を行った。第一に、組織特異的に性ホルモン受容体を欠く遺伝子変異マウスを作製し、表現型解析から性分化過程での生理学適宜を検討した。第二に、性ホルモン受容体の転写活性に必須となる転写共役因子群の機能解析により、組織特異的な転写制御機構を解明した。これらの機能解析により、これまで判然としなかった性ホルモンによる性分化機構が、性ホルモン受容体を介した転写制御により発揮されることが明確となった。
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Research Products
(66 results)
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[Journal Article] DNA demethylation for hormone-induced transcriptional derepression2009
Author(s)
Kim, M. S., Kondo, T., Takada, I., Youn, M., Yamamoto, Y., Takahashi, S., Matsumoto, T., Fujiyama, S., Shirode, Y., Yamaoka, I., Kitagawa, H., Takeyama, K., Shibuya, H., Ohtake, F. and Kato, S.
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Journal Title
Peer Reviewed
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[Journal Article] GlcNAcylation of a histone methyltransferase in retinoic acid-induced granulopoiesis2009
Author(s)
Fujiki, R., Chikanishi, T., Hashiba, W., Ito, H., Takada, I., Roeder, R. G., Kitagawa, H. and Kato, S.
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Journal Title
Nature 459
Pages: 455-459
Peer Reviewed
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[Journal Article] Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity2009
Author(s)
Suzuki, E., Zhao, Y., Ito, S., Sawatsubashi, S., Murata, T., Furutani, T., Shirode, Y., Yamagata, K., Tanabe, M., Kimura, S., Ueda, T., Fujiyama, S., Lim, J., Matsukawa, H., Kouzmenko, A. P., Aigaki, T., Tabata, T., Takeyama, K. and Kato, S.
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Journal Title
Proc Natl Acad Sci USA 106
Pages: 3818-3822
Peer Reviewed
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[Journal Article] Co-repressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system2008
Author(s)
Zhao, Y., Takeyama, K., Sawatsubashi, S., Ito, S., Suzuki, E., Yamagata, K., Tanabe, M., Kimura, S., Fujiyama, S., Ueda, T., Murata, T., Matsukawa, H., Shirode, Y., Kouzmenko, A.P., Li, F., Tabata, T. and Kato, S.
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Journal Title
Mol Cell Biol 29
Pages: 1017-1034
Peer Reviewed
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[Journal Article] Activation of facultatively silenced Drosophila loci associates with increased acetylation of histone H2AvD2008
Author(s)
Tanabe, M., Kouzmenko, AP., Ito, S., Sawatsubashi, S., Suzuki, E., Fujiyama, S., Yamagata, K., Zhao, Y., Kimura, S., Ueda, T., Murata, T., Matsukawa, H., Takeyama, K. and Kato, S.
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Journal Title
Genes Cells 13
Pages: 1279-1288
Peer Reviewed
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[Journal Article] RNA-binding protein hoip accelerates polyQ-induced neurodegeneration in Drosophila2008
Author(s)
Murata, T., Suzuki, E., Ito, S., Sawatsubashi, S., Zhao, Y., Yamagata, K., Tanabe, M., Fujiyama, S., Kimura, S., Ueda, T., Matsukawa, H., Kouzmenko, A., Furutani, T., Kuranaga, E., Miura, M., Takeyama, K. and Kato, S.
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Journal Title
Biosci Biotechnol Biochem 72
Pages: 2255-2261
Peer Reviewed
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[Journal Article] Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor2008
Author(s)
Kimura, S., Sawatsubashi, S., Ito, S., Kouzmenko, A., Suzuki, E., Zhao, Y., Yamagata, K., Tanabe, M., Ueda, T., Fujiyama, S., Murata, T., Matsukawa, H., Takeyama, K., Yaegashi, N. and Kato, S.
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Journal Title
Biochem Biophys Res Commun 371
Pages: 889-893
Peer Reviewed
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[Journal Article] Switching of chromatin-remodelling complexes for oestrogen receptor-alpha2008
Author(s)
Okada, M., Takezawa, S., Mezaki, Y., Yamaoka, I., Takada, I., Kitagawa, H. and Kato, S.
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Journal Title
EMBO Rep 9
Pages: 563-568
Peer Reviewed
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[Journal Article] A2E, a pigment of the lipofuscin of retinal pigment epithelial cells, is an endogenous ligand for retinoic acid receptor2008
Author(s)
Iriyama, A., Fujiki, R., Inoue, Y., Takahashi, H., Tamaki, Y., Takezawa, S., Takeyama, K., Jang, W.D., Kato, S. and Yanagi Y.
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Journal Title
J Biol Chem 283
Pages: 11947-11953
Peer Reviewed
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[Journal Article] A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing2008
Author(s)
Zhao, Y., Lang, G., Ito, S., Bonnet, J., Metzger, E., Sawatsubashi, S., Suzuki, E., Le Guezennec, X., Stunnenberg, H.G., Krasnov, A., Georgieva, S.G., Schule, R., Takeyama, K., Kato, S., Tora, L. and Devys, D.
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Journal Title
Mol Cell 29
Pages: 92-101
Peer Reviewed
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[Journal Article] Dihydrotestosterone inhibits murine hair growth via the androgen receptor2008
Author(s)
Naito, A., Sato, T., Matsumoto, T., Takeyama, K., Yoshino, T., Kato, S. and Ohdera, M.
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Journal Title
Br J Dermatol 159
Pages: 300-305
Peer Reviewed
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[Journal Article] Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene2007
Author(s)
Igarashi, M., Yogiashi, Y., Mihara, M., Takada, I., Kitagawa, H. and Kato, S.
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Journal Title
Mol Cell Biol 27
Pages: 7947-7954
Peer Reviewed
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[Journal Article] A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation2007
Author(s)
Takada, I., Mihara, M., Suzawa, M., Ohtake, F., Kobayashi, S., Igarashi, M., Youn, M. Y., Takeyama, K., Nakamura, T., Mezaki, Y., Takezawa, S., Yogiashi, Y., Kitagawa, H., Yamada, G., Takada, S., Minami, Y., Shibuya, H., Matsumoto, K. and Kato, S.
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Journal Title
Nat Cell Biol 9
Pages: 1273-1285
Peer Reviewed
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[Journal Article] High-throughput system for analyzing ligand-induced cofactor recruitment by vitamin D receptor2007
Author(s)
Arai, M. A., Takeyama, K., Ito, S., Kato, S., Chen, T. C. and Kittaka, A.
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Journal Title
Bioconjug Chem 18
Pages: 614-620
Peer Reviewed
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[Journal Article] Dioxin receptor is a ligand-dependent E3 ubiquitin ligase2007
Author(s)
Ohtake, F., Baba, A., Takada, I., Okada, M., Iwasaki, K., Miki, H., Takahashi, S., Kouzmenko, A. P., Nohara, K., Chiba, T., Fujii-Kuriyama, Y. and Kato, S.
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Journal Title
Nature 446
Pages: 562-566
Peer Reviewed
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[Journal Article] Androgen receptor function in folliculogenesis and its clinical implication in premature ovarian failure2007
Author(s)
Kimura, S., Matsumoto, T., Matsuyama, R., Shiina, H., Sato, T., Takeyama, K. and Kato, S.
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Journal Title
Trends Endocrinol Metab 18
Pages: 183-189
Peer Reviewed
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[Journal Article] DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs2007
Author(s)
Fukuda, T., Yamagata, K., Fujiyama, S., Matsumoto, T., Koshida, I., Yoshimura, K., Mihara, M., Naitou, M., Endoh, H., Nakamura, T., Akimoto, C., Yamamoto, Y., Katagiri, T., Foulds, C., Takezawa, S., Kitagawa, H., Takeyama, K., O'Malley, B. W. and Kato, S.
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Journal Title
Nat Cell Biol 9
Pages: 604-611
Peer Reviewed
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[Journal Article] Id2 gene-targeted crosstalk between Wnt and retinoid signaling regulates proliferation in human keratinocytes2007
Author(s)
Memezawa, A., Takada, I., Takeyama, K., Igarashi, M., Ito, S., Aiba, S., Kato, S. and Kouzmenko, A. P.
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Journal Title
Oncogene 26
Pages: 5038-5045
Peer Reviewed
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[Journal Article] A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function2007
Author(s)
Takezawa, S., Yokoyama, A., Okada, M., Fujiki, R., Iriyama, A., Yanagi, Y., Ito, H., Takada, I., Kishimoto, M., Miyajima, A., Takeyama, K., Umesono, K., Kitagawa, H. and Kato, S.
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Journal Title
Peer Reviewed
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[Journal Article] 1Alpha, 25(OH)2D3-induced transrepression by vitamin D receptor through E-box-type elements in the human parathyroid hormone gene promoter2007
Author(s)
Kim, M. S., Fujiki, R., Murayama, A., Kitagawa, H., Yamaoka, K., Yamamoto, Y., Mihara, M., Takeyama, K. and Kato, S.
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Journal Title
Mol Endocrinol 21
Pages: 334-342
Peer Reviewed
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[Journal Article] The pituitary function of androgen receptor constitutes a glucocorticoid production circuit2007
Author(s)
Miyamoto, J., Matsumoto, T., Shiina, H., Inoue, K., Takada, I., Ito, S., Itoh, J., Minematsu, T., Sato, T., Yanase, T., Nawata, H., Osamura, Y. R. and Kato, S.
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Journal Title
Mol Cell Biol 24
Pages: 4807-4814
Peer Reviewed
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[Journal Article] Culture serum-induced conversion from agonist to antagonist of a Vitamin D analog, TEI-96472006
Author(s)
Yamaoka, K., Kim, M., Takada, I., Takeyama, K., Kamimura, T. and Kato, S.
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Journal Title
J Steroid Biochem Mol Biol 100
Pages: 177-183
Peer Reviewed
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[Journal Article] Premature ovarian failure in androgen receptor-deficient mice2006
Author(s)
Shiina, H., Matsumoto, T., Sato, T., Igarashi, K., Miyamoto, J., Takemasa, S., Sakari, M., Takada, I., Nakamura, T., Metzger, D., Chambon, P., Kanno, J., Yoshikawa, H. and Kato, S.
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Journal Title
Proc Natl Acad Sci USA 103
Pages: 224-229
Peer Reviewed
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[Journal Article] An hGCN5/TRRAP HAT complex coactivates BRCA1 transactivation function through histone modification2006
Author(s)
Oishi, H., Kitagawa, H., Wada, O., Takezawa, S., Tora, L., Kouzu-Fujita, M., Takada, I., Yano, T., Yanagisawa, J. and Kato, S.
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Journal Title
J Biol Chem 281
Pages: 20-26
Peer Reviewed
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[Journal Article] Human expanded polyQ androgen receptor mutants in neurodegeneration as a novel ligand target2005
Author(s)
Furutani, T., Takeyama, K., Koutoku, H., Ito S., Taniguchi N., Suzuki E., Kudoh, M., Shibasaki, M., Shikama, H. and Kato, S.
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Journal Title
J Pharmacol Exp Ther 315
Pages: 545-552
Peer Reviewed
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[Journal Article] A role of androgen receptor protein in cell growth of an androgen-independent prostate cancer cell line2005
Author(s)
Furutani, T., Takeyama, K., Koutoku, H., Ito, S., Taniguchi, N., Suzuki, E., Kudoh, M., Shibasaki, M., Shikama, H. and Kato, S.
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Journal Title
Biosci Biotechnol Biochem 69
Pages: 2236-2239
Peer Reviewed
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[Journal Article] Splicing potentiation by growth factor signals via estrogen receptor phosphorylation2005
Author(s)
Masuhiro, Y., Mezaki, Y., Sakari, M., Takeyama, K., Yoshida, T., Inoue, K., Yanagisawa, J., Hanazawa, S., O'Malley, B. W. and Kato, S.
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Journal Title
Proc Natl Acad Sci USA 102
Pages: 8126-8131
Peer Reviewed
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[Journal Article] TRRAP as a hepatic coactivator of LXR and FXR function2005
Author(s)
Unno, A., Takada, I., Takezawa, S., Oishi, H., Baba, A., Shimizu, T., Tokita, A., Yanagisawa, J. and Kato, S.
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Journal Title
Biochem Biophys Res Commun 327
Pages: 933-938
Peer Reviewed
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[Journal Article] Wnt/beta -catenin and estrogen signaling converge in vivo2004
Author(s)
Kouzmenko, A. P., Takeyama, K., Ito, S., Furutani, T., Sawatsubashi, S., Maki, A., Suzuki, E., Kawasaki, Y., Akiyama, T., Tabata, T. and Kato, S.
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Journal Title
J Biol Chem 279
Pages: 40255-40258
Peer Reviewed
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[Journal Article] In vivo potentiation of human oestrogen receptor αby Cdk7-mediated phosphorylation2004
Author(s)
Ito, S., Takeyama, K., Yamamoto, A., Sawatsubashi, S., Shirode, Y., Kouzmenko, A. P., Tabata, T. and Kato, S.
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Journal Title
Genes Cells 9
Pages: 983-992
Peer Reviewed
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[Journal Article] BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP2202004
Author(s)
Wada, O., Oishi, H., Takada, I., Yanagisawa, J., Yano, T. and Kato, S.
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Journal Title
Oncogene 23
Pages: 6000-6005
Peer Reviewed
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[Journal Article] A novel genetic system for analysis of co-activators for the N-terminal transactivation function domain of the human androgen receptor2004
Author(s)
Takeyama, K., Ito, S., Sawatsubashi, S., Shirode, Y., Yamamoto, A., Suzuki, E., Maki, A., Yamagata, K., Zhao, Y., Kouzmenko, A. P., Tabata, T.and Kato, S.
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Journal Title
Biosci Biotechnol Biochem 68
Pages: 1209-1215
Peer Reviewed
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[Journal Article] Ecdysone receptor-dependent gene regulation mediates histone poly (ADP-ribosyl)ation2004
Author(s)
Sawatsubashi, S., Maki, A., Ito, S., Shirode, Y., Suzuki, E., Zhao, Y., Yamagata, K., Kouzmenko, A., Takeyama, K. and Kato, S.
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Journal Title
Biochem Biophys Res Commun 320
Pages: 268-272
Peer Reviewed
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[Journal Article] Juvenile hormones antagonize ecdysone actions through co-repressor recruitment to EcR/USP heterodimers2004
Author(s)
Maki, A., Sawatsubashi, S., Ito, S., Shirode, Y., Suzuki, E., Zhao, Y., Yamagata, K., Kouzmenko, A., Takeyama, K. and Kato, S.
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Journal Title
Biochem Biophys Res Commun 320
Pages: 262-267
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[Presentation] 新規クロマチン構造調節因子BAHD1を介した転写抑制機構の解明2008
Author(s)
伊藤紗弥, 沢津橋俊, 鈴木絵里子, 趙越, 山形薫, 田辺真彦, 木村周平, 上田崇, 藤山沙理, 村田拓哉, 松川紘之, 林珍仙, 武山健一, 加藤茂明
Organizer
第31回日本分子生物学会、第81回日本生化学会合同大会
Place of Presentation
神戸
Year and Date
20081209-12
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[Presentation] エストロゲンによるmiRNA産生抑制機構の解析2008
Author(s)
山形薫, 鈴木絵里子, 沢津橋俊, 伊藤紗弥, 藤山沙理, 田辺真彦, 上田崇, 村田拓哉, 趙越, 松川紘之, 林珍仙, 汐崎裕美, 武山健一, 加藤茂明
Organizer
第31回日本分子生物学会、第81回日本生化学会合同大会
Place of Presentation
神戸
Year and Date
20081209-12
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[Presentation] ショウジョウバエZn-fingerタンパクZ4の新規クロマチン凝集化機能の解析2008
Author(s)
村田拓哉, 沢津橋俊, 伊藤紗弥, 鈴木絵里子, 山形薫, 趙越, 田辺真彦, 藤山沙理, 木村周平, 上田崇, 松川紘之, 林珍仙, 武山健一, 加藤茂明
Organizer
第31回日本分子生物学会、第81回日本生化学会合同大会
Place of Presentation
神戸
Year and Date
20081209-12
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[Presentation] 分子遺伝学的手法による新規転写共役因子の網羅的探索法の構築と機能解析2008
Author(s)
武山健一, 伊藤紗弥, 沢津橋俊, 鈴木絵里子, 趙越, 山形薫, 田辺真彦, 木村周平, 上田崇, 藤山沙理, 村田拓也, 松川紘之, Alexander Kouzmenko, 加藤茂明
Organizer
2008年度日本農芸化学会大会
Place of Presentation
名古屋
Year and Date
20080326-29
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[Presentation] 遺伝学的アプローチとプロテオミクスを連携した新規活性化クロマチン構造調節因子の網羅的探索と機能解析2007
Author(s)
藤山沙理, 沢津橋俊, 鈴木絵里子, 伊藤紗弥, 田辺真彦, 趙越, 木村周平, 上田崇, 山形薫, 村田拓哉, 松川紘之, 武山健一, 加藤茂明
Organizer
第30回日本分子生物学会, 第80回日本生化学会合同大会
Place of Presentation
横浜
Year and Date
20071211-15
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[Presentation] Notchシグナル伝達依存的な新規転写抑制因子の同定と機能解析2007
Author(s)
武山健一, 伊藤紗弥, 沢津橋俊, Alexander Kouzmenko, 鈴木絵里子, 山形薫, 趙越, 田辺真彦, 木村周平, 上田崇, 村田拓也, 藤山沙理, 加藤茂明
Organizer
2007年度日本農芸化学会大会
Place of Presentation
東京
Year and Date
20070324-27
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[Presentation] 分子遺伝学的アプローチによるヒト核内レセプター新規転写共役因子BAHD1の機能解析2006
Author(s)
伊藤紗弥, 武山健一, 沢津橋俊, 鈴木絵里子, Yue Zhao, 山形薫, 田辺真彦, Alexander Kouzmenko, 城出裕子, 多羽田哲也, 加藤茂明
Organizer
2006年度日本農芸化学会大会
Place of Presentation
京都
Year and Date
20060325-28
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[Presentation] ポリグルタミン鎖伸長異常アンドロゲンレセプターによって引き起こされる神経変性はRb/E2F-1転写調節機能の抑制化により回復する2005
Author(s)
鈴木絵里子, 武山健一, 伊藤沙弥, 沢津橋俊, 城出裕子, 真木彰郎, 山形薫, 趙越, Alexandr Kouzmenko, 相垣敏郎, 多羽田哲也, 加藤茂明
Organizer
2005年度日本農芸化学会大会
Place of Presentation
札幌
Year and Date
20050328-30
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[Presentation] 分子遺伝学的アプローチによるヒト核内レセプター転写共役因子の探索と機能解析2005
Author(s)
武山健一, 伊藤紗弥, 沢津橋俊, 城出裕子, 鈴木絵里子, 真木彰郎, 趙越, 山形薫, Alexander Kouzmenko, 田辺真彦, 多羽田哲也, 加藤茂明
Organizer
2005年度日本農芸化学会大会
Place of Presentation
札幌
Year and Date
20050328-30
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[Presentation] アンドロゲンレセプターを介したE2F-1/Rb転写制御機構の解析2004
Author(s)
鈴木絵里子, 武山健一, 伊藤紗弥, 沢津橋俊, 城出裕子, 真木彰郎, 山形薫, 趙越, Alexander Kouzmenko, 相垣敏郎, 多羽田哲也, 加藤茂明
Organizer
第27回日本分子生物学会年会
Place of Presentation
神戸
Year and Date
20041108-11
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[Presentation] 分子遺伝学的アプローチによるヒト性ステロイドホルモンレセプター新規転写制御因子の網羅的Screening系の構築2004
Author(s)
伊藤紗弥, 武山健一, 沢津橋俊, Alexandre Kouzmenko, 城出裕子, 鈴木絵里子, 真木彰郎, Yue Zhao, 山形薫, 相垣敏郎, 多羽田哲也, 加藤茂明
Organizer
第27回日本分子生物学会年会
Place of Presentation
神戸
Year and Date
20041108-11
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