Analysis of the developmental cascade of the mammalian external genitalia

2008 Fiscal Year Final Research Report

• Project/Area Number: 16086208
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kumamoto University
• Principal Investigator: YAMADA Gen Kumamoto University, 生命資源研究・支援センター, 教授 (80174712)
• Project Period (FY): 2004 – 2008
• Keywords: 生殖器 / 性分化 / 器官形成 / 細胞増殖因子 / 発生プログラム

Research Abstract

哺乳類外生殖器形成に関わる細胞増殖因子系の機能を世界で初めて明らかにした。胎児後端において総排泄腔近傍から発生する外生殖器の組織系譜を解明し、生殖器官が協調して発生するメカニズム解明を行なった。細胞増殖因子群として重要なWnt 群の機能解析を行なった。本プロジェクトにより初めて哺乳類外生殖器の器官形成カスケードが解明され、有力国際学術雑誌に発表を行ない世界の研究をリードした。

Research Products

• [Journal Article] Embryonic hair follicle fate change by augmented β-catenin through Shh and Bmp signaling (2009)
  • Author(s): Suzuki, K., and Yamada, G
  • Journal Title: Development 136 Pages: 367-372
  • Peer Reviewed
• [Journal Article] Positive regulation of steroidogenic acute regulatory protein (StAR) gene expression through the interaction between Dlx and GATA-4 for testicular steroidogenesis (2008)
  • Author(s): Nishida, H., and Yamada, G.
  • Journal Title: Endocrinology 149 Pages: 2090-7
  • Peer Reviewed
• [Journal Article] Cessation of gastrulation is mediated by suppression of Epithelial-Mesenchymal Transition (EMT) at the Ventral ectodermal ridge (2007)
  • Author(s): Ohta, S., Suzuki, K., Tachibana, K., Tanaka, H. and Yamada, G.
  • Journal Title: Development 134 Pages: 4315-24
  • Peer Reviewed
• [Journal Article] Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling (2007)
  • Author(s): Haraguchi, R., and Yamada, G.
  • Journal Title: Development 134 Pages: 525-533
  • Peer Reviewed
• [Journal Article] Genetic interactions of the Androgen and Wnt/β-catenin Pathways for the Masculinization of External Genitalia
  • Author(s): Miyagawa, S., and Yamada, G.
  • Journal Title: Mol. Endocrinol. (in press)
  • Peer Reviewed
• [Presentation] Speakers : Ahmed Mansouri, Hongkui Deng, Jacques Drouin, Seppo Vainio, Connie Eaves, 山中伸也 (2008)
  • Author(s): Gen Yamada(オーガナイザー)
  • Organizer: The 1st Kumamoto University Global COE International Symposium on Cell Fate Regulation
  • Place of Presentation: Kumamoto, Japan
  • Year and Date: 20080000
• [Presentation] (2007)
  • Author(s): Gen Yamada
  • Organizer: The 2nd Asian Mouse Mutagenesis and Resource Association (AMMRA) Meeting
  • Place of Presentation: Nanjing, China,
  • Year and Date: 20071122-24
• [Presentation] Studies relevant to mouse limbs (2006)
  • Author(s): Chairman : Gen Yamada (Speaker : Dr. Aris N Economides, Dr. Jeffrey W. Innis and Dr. Gen Yamada)
  • Organizer: 9th International Conference on Limb Development and Regeneration
  • Place of Presentation: Awaji, Japan
  • Year and Date: 20060700
• [Presentation] External genitalia formation ; a glamorous developmental model system? Reproductive Tract Biology (2006)
  • Author(s): Yamada,G
  • Organizer: Gordon(ゴードン)Conference
  • Place of Presentation: New London, CT, USA.
  • Year and Date: 20060000
• [Presentation] Molecular Analysis of External Genitalia Formation : integration of growth factors and transcription factors for the regulation of Murine Genital Tubercle (GT) Development (2004)
  • Author(s): Yamada, G
  • Organizer: Mouse Molecular Genetics, CSH Meeting
  • Place of Presentation: Cold Spring Harbor, USA
  • Year and Date: 20040000
• [Remarks]
  • URL: http://hdl.handle.net/2298/10388
• [Remarks]
  • URL: http://hdl.handle.net/2298/10390