Molecular basis of nuclear receptors and their downstream targets in aging

2008 Fiscal Year Final Research Report

• Project/Area Number: 16109003
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: INOUE Satoshi The University of Tokyo, 医学部・附属病院, 特任教授 (40251251)
• Co-Investigator(Kenkyū-buntansha): URANO Tomohiko 東京大学, 医学部・附属病院, 特任助教 (20334386) ; TSUKUI Toru 埼玉医科大学, 医学部・, 講師 (10333006)
• Project Period (FY): 2004 – 2008
• Keywords: 老化 / 受容体 / ホルモン

Research Abstract

本研究では老化と加齢に伴い増加する疾患における核内受容体とその標的因子、共役因子、修飾因子の新規同定を行い、生理機能ならびに病態における役割を探求した、核内受容体と標的因子の新しい分子作用メカニズム、新規リガンド、シグナル経路を明らかにした。

Research Products

• [Journal Article] Association of estrogen receptor α and histone deacetylase 6 causes rapid decetylation of tubulin in breast cancer cell (2009)
  • Author(s): Azuma K, Urano T, Horie-Inoue K, Hayashi S, Sakai R, Ouchi Y, Inoue S
  • Journal Title: Cancer Res 69 Pages: 2935-2940
  • Peer Reviewed
• [Journal Article] Amyloid precursor protein is a primary androgen target gene that promotes prostate cancer growth (2009)
  • Author(s): Takayama K, Tsutsumi T, Suzuki T,Horie-Inoue K, Ikeda K, Kaneshiro K, Fujimura T, Kumagai J, Urano T, Sakaki Y, Shirahige K, Sasano H, Takahashi S,Kitamura T, Ouchi Y, Aburatani H, Inoue S
  • Journal Title: Cancer Res 69 Pages: 137-142
  • Peer Reviewed
• [Journal Article] Modulation of adipogenesis-related gene expression by estrogen-related receptor during adipocytic differentiation (2009)
  • Author(s): Kubo M, Ijichi N, Ikeda K, Horie-Inoue K, Takeda S, Inoue S
  • Journal Title: Biochim Biophys Acta -Gene Regulatory Mechanisms 1798 Pages: 71-77
  • Peer Reviewed
• [Journal Article] TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity (2007)
  • Author(s): Gack MU, Shin YC, Joo CH, Urano T, Liang C, Sun L, Takeuchi O, Akira S, Chen Z, Inoue S, Jung JU
  • Journal Title: Nature 446 Pages: 916-921
  • Peer Reviewed
• [Journal Article] Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells (2007)
  • Author(s): Ichikawa T, Horie-Inoue K, Ikeda K, Blumberg B, Inoue S
  • Journal Title: J Mol Endocrinol 39 Pages: 239-247
  • Peer Reviewed
• [Journal Article] synuclein stimulates differentiation of osteosarcoma cells : Relevance to downregulation of proteasome activity. (2007)
  • Author(s): Fujita M, Sugama S, Nakai M, Takenouchi T, Wei J, Urano T, Inoue S, Hashimoto M
  • Journal Title: J Biol Chem 282 Pages: 5736-5748
  • Peer Reviewed
• [Journal Article] Steroid and xenobiotic receptor SXR mediates vitamin K2-activated transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells (2006)
  • Author(s): Ichikawa T, Horie-Inoue K, Ikeda K, Blumberg B, Inoue S
  • Journal Title: J Biol Chem 281 Pages: 16927-16934
  • Peer Reviewed
• [Journal Article] 17ss-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxindependent redox regulation of Akt in myocardiac H9c2 cell (2006)
  • Author(s): Urata Y, Ihara Y, Murata H, Goto S, Koji T, Yodoi J, Inoue S, Kondo T
  • Journal Title: J Biol Chem 281 Pages: 13092-13102
  • Peer Reviewed
• [Journal Article] Estrogen receptor-binding fragment-associated antigen 9 is a tumor-promoting and prognostic factor for renal cell carcinoma (2005)
  • Author(s): Ogushi T, Takahashi S, Takeuchi T, Urano T, Horie-Inoue K, Kumagai J, Kitamura T, Ouchi Y, Muramatsu M, Inoue S
  • Journal Title: Cancer Res 65 Pages: 3700-3706
  • Peer Reviewed
• [Journal Article] Estrogen-responsive finger protein as a new potential biomarker for breast cancer (2005)
  • Author(s): Suzuki T, Urano T, Tsukui T, Horie-Inoue K,Moriya T, Ishida T, Muramatasu M, Ouchi Y,Sasano H, Inoue S
  • Journal Title: Clin Cancer Res 11 Pages: 6148-6154
• [Journal Article] 14-3-3 in endometrial cancer A possible prognostic marker in early stage cancer (2005)
  • Author(s): Ito K, Suzuki T, Akahira J, Sakuma M,Saitou S, Okamoto S, Niikura H, Okamura K,Yaegashi N, Sasano H, Inoue S
  • Journal Title: Clin Caner Res 11 Pages: 7384-7391
  • Peer Reviewed
• [Journal Article] Protein phosphatase 5 is a negative regulator of estrogen receptor-mediated transcription (2004)
  • Author(s): Ikeda K, Ogawa S, Tsukui T, Horie-Inoue K,Ouchi Y, Kato S, Muramatsu M, Inoue S
  • Journal Title: Mol Endocrinol 18 Pages: 1131-1143
  • Peer Reviewed
• [Journal Article] Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by RIG-I.
  • Author(s): Gack MU, Albrecht RA, Urano T, Inn KS, Huang IC, Carnero E, Farzan M, Inoue S, Jung JU, Garcia-Sastre A
  • Journal Title: Cell Host , Microbe (in press)
  • Peer Reviewed
• [Journal Article] The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
  • Author(s): Suzuki H, Inoue S, Hayashizaki Y(他157名)
  • Journal Title: Nat Genet (in press)
  • Peer Reviewed
• [Journal Article] Identification of Igf2, Igfbp2 and Enpp2 as estrogen-responsive genes in rat hippocampus
  • Author(s): Takeo C, Ikeda K, Horie-Inoue K, Inoue S
  • Journal Title: Endocrine J (in press)
  • Peer Reviewed
• [Presentation] [Symposium, Invited Talk] Newestrogen target genes (2008)
  • Author(s): Inoue S
  • Organizer: 13^<th> International Congress of Endocrinology, Rio de Janeiro
  • Place of Presentation: Brazil
  • Year and Date: 20081108-12
• [Presentation] [Invited Talk]New Target Genes forSteroid Hormones (2008)
  • Author(s): Inoue S
  • Organizer: CBI Annual Meeting 2008 International Symposium
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 20081022-24
• [Presentation] [特別講演]女性ホルモンの作用機構とホルモン補充療法 (2008)
  • Author(s): 井上聡
  • Organizer: 第26回日本美容皮膚科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20080830-31
• [Presentation] [Invited Talk]Protein modification of 14-3-3sigma by TRIM E3 ligase (2008)
  • Author(s): Inoue S
  • Organizer: Biology of 14-3-3 Proteins
  • Place of Presentation: Gordon Research Conferences, Ventura,California, USA
  • Year and Date: 20080224-29
• [Presentation] [Invited Talk] Novel Vitamin K action via transcriptional regulation (2007)
  • Author(s): Inoue S
  • Organizer: 4^<th> Meeting of Bone Biology Forum
  • Place of Presentation: Shizuoka, Japan
  • Year and Date: 2007-08-24
• [Presentation] [Invited Talk] Post-translational modification of 14-3-3sigma by E3 ligase Efp (2006)
  • Author(s): Inoue S
  • Organizer: 2006 GRC on Biology of 14-3-3 Protein
  • Place of Presentation: Gordon Research Conference, Oxford, UK
  • Year and Date: 20060827-0901
• [Presentation] [学術賞受賞講演] 骨代謝疾患の治療薬作用機構ならびに疾患遺伝子の探索 (2006)
  • Author(s): 井上聡
  • Organizer: 第24回日本骨代謝学会
  • Place of Presentation: 東京
  • Year and Date: 20060706-8
• [Presentation] [研究奨励賞受賞講演]エストロゲン標的遺伝子の同定とその機能の解明 (2006)
  • Author(s): 井上聡
  • Organizer: 第79回日本内分泌学会学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2006-05-19
• [Presentation] [Luncheon Seminar] Novel mechanism of vitamin K action via transcriptional regulation (2005)
  • Author(s): Inoue S
  • Organizer: International Interdisciplinary Conference on Vitamins, Coenzymes, and Biofactors 2005
  • Place of Presentation: Awaji, Japan
  • Year and Date: 20051107-11
• [Presentation] [Symposium]"Molecular and cellular analysis of steroid hormone receptor : Expression and its role in reproductive organs"Estrogen receptors and their downstream targets in b east tumors (2004)
  • Author(s): Inoue S
  • Organizer: 16^<th> International Congress of the IFAA (International Federation of Associations of Anatomists
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20040822-27
• [Book] 40歳からの女性の医学骨粗鬆症-骨のアンチエイジング- (2008)
  • Author(s): 井上聡
  • Total Pages: 111
  • Publisher: 岩波書店
• [Remarks]
  • URL: http://www.h.u-tokyo.ac.jp/center22/koukarei.html