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2008 Fiscal Year Final Research Report

Investigation of regulatory mechanisms for homeostasis and activation of lymphocyte

Research Project

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Project/Area Number 16109004
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionThe University of Tokyo (2004-2005, 2008)
University of Toyama (2006-2007)

Principal Investigator

TAKATSU Kiyoshi  The University of Tokyo, 大学院・医学薬学研究部, 教授 (10107055)

Co-Investigator(Kenkyū-buntansha) TAKAKI Satoshi  国立国際医療センター, 研究所, 部長 (10242116)
NAGAI Yoshinori  富山大学, 大学院・医学薬学研究部, 准教授 (30431761)
KOURO Taku  (独)医薬基盤研究所, 免疫応答制御プロジェクト, プロジェクトリーダー (90372424)
TAMURA Toshiki  国立感染症研究所, ハンセン病研究センター, 室長 (40291306)
Project Period (FY) 2004 – 2007
Keywords免疫学 / 自然免疫 / インターロイキン / アダプター分子 / クラススイッチ変換
Research Abstract

Bリンパ球のホメオスターシスと活性化の動態を制御するIL-5とLnkアダプターファミリー分子に焦点をあて、B-1細胞の恒常性維持やB-2細胞のIgHクラススイッチ組み換え、造血幹細胞増殖の制御にどのように関わるか明らかにして、Tリンパ球の分化との関係を分子レベルで明らかにする。

  • Research Products

    (34 results)

All 2009 2008 2007 2006 2005 2004

All Journal Article (10 results) Presentation (18 results) Book (6 results)

  • [Journal Article] Role of IL-5 in the Immune response to inflammation2009

    • Author(s)
      Takatsu K, Kouro T, Nagai Y
    • Journal Title

      Adv. Immunol 101

      Pages: 191-236

  • [Journal Article] Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production2009

    • Author(s)
      Tsukamoto Y, Nagai Y, Kariyone A, Shibata T, Kaisho T, Akira S, Miyake K, Takatsu K
    • Journal Title

      Mol. Immunol 46

      Pages: 1278-1288

  • [Journal Article] Initiation of the adaptive immune response to M. tuberculosis depends on antigen production in the local lymph node, not the lungs2008

    • Author(s)
      Wolf, AJ, Desvignes L, Linas B, Banaiee N, Tamura T, Takatsu K, Ernst JD
    • Journal Title

      J. Exp. Med 205

      Pages: 105-115

  • [Journal Article] IL-5 and eosino-philia2008

    • Author(s)
      Takatsu K, Nakajima H
    • Journal Title

      Curr. Opin. Immunol 20

      Pages: 288-295

  • [Journal Article] IL-5-induced eosinophils can suppress the antigen-induced immune response via a TGF-β-dependent mechanism2007

    • Author(s)
      Nakagome K, Dohi M, Okunishi K, Taanaka R, T. Kouro T, Kano MR, Miyazono K, Miyazaki J, Takatsu K, Yamamoto K
    • Journal Title

      J. Immunol 179

      Pages: 284-294

  • [Journal Article] Instruction of CD4^+ T cell fate to T-bet expression and Th1 development by Th1-inducing peptide : roles of T cell receptor-mediated signals2007

    • Author(s)
      Ariga H, Shimohakamada Y, Tokunaga T, Kikuchi T, Nakata M, Kariyone A, Tamura T, Takatsu K
    • Journal Title

      Immunology 122

      Pages: 210-221

  • [Journal Article] Interleukin-5 regulates genes involved in B cell terminal maturation2006

    • Author(s)
      Horikawa K, Takatsu K
    • Journal Title

      Immunology 118

      Pages: 497-508

  • [Journal Article] Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein2006

    • Author(s)
      Takizawa H, Kubo-Akashi C, Nobuhisa I, Kwon S.-M., Iseki M, Taga T, Takatsu K, Takaki S
    • Journal Title

      Lnk, Blood 107

      Pages: 2968-2975

  • [Journal Article] The role of antigenic peptide in CD4^+ T helper phenotype development in a T cell receptor transgenic model2004

    • Author(s)
      Tamura T, Ariga H, Kinashi T, Uehara S, Kikuchi T, Nakada M, Tokunaga T, Kariyone A, Saito T, Kitamura T, Maxwell G, Takaki S, Takatsu K
    • Journal Title

      Int. Immunol 15

      Pages: 1691-1699

  • [Journal Article] The role of IL-5 for mature B-1 cells in homeostatic proliferation, cell survival, and Ig production2004

    • Author(s)
      Moon B.-G., Takaki S, Miyake K, Takatsu K. J. Immunol
    • Journal Title

      J. Immunol 172

      Pages: 6020-6029

  • [Presentation] P25CD4^+T細胞活性化とクロスプライミング増強の解析2007

    • Author(s)
      刈米アイ、田村敏生、高津聖志
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20071100
  • [Presentation] Control of Dendritic Cell Production by Lnk/SH2B3 Adaptor Protein, a Negative Regulator of Lymphohematopoiesis2007

    • Author(s)
      Iwasaki Y, Takizawa H, Yamamoto K, Takatsu K, Takaki S
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20071100
  • [Presentation] Dynamic expression patterns of Lnk, a negative regulatory adaptor in lymphohematopoiesis revealed by generating a GFP knock-in reporter mice2007

    • Author(s)
      Katayama H, Ikutani M, Yoshida N, Takatsu K, Takaki S
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20071100
  • [Presentation] Control of cell adhesion and migration in B lymphocytes and hematopoietic progenitors by Lnk, a negative regulator of cytokine signaling2007

    • Author(s)
      Takaki S, Iwasaki Y, Kubo C, Takizawa H, Takatsu K
    • Organizer
      13th International Congress of Immunology
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Year and Date
      20070800
  • [Presentation] Lnk, An Adaptor Protein, Modulates Signals mediated through integrins and cytokine receptors in hematopoietic progenitors2007

    • Author(s)
      Takizawa H, Eto K, Nakauchi H, Takatsu K, Takaki S
    • Organizer
      13th International Congress of Immunology
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Year and Date
      20070800
  • [Presentation] 免疫バイオ研究と創薬探索2007

    • Author(s)
      高津聖志
    • Organizer
      医療薬学フォーラム2007
    • Place of Presentation
      山形
    • Year and Date
      20070700
  • [Presentation] 免疫と炎症を制御するシグナル、IL-5の関与とその謎2007

    • Author(s)
      高津聖志
    • Organizer
      第16回東京免疫フォーラム(特別講演)
    • Place of Presentation
      東京
    • Year and Date
      20070300
  • [Presentation] Genes involved in Btk-dependent pro-B to pre-B transition, Keystone Symposia2007

    • Author(s)
      Ikutani M, Kouro T, Takaki S, Takatsu K
    • Organizer
      Banff
    • Place of Presentation
      Canada
    • Year and Date
      20070100
  • [Presentation] Expression of IL-5 receptor a chain on B-1 cell progression2006

    • Author(s)
      Kouro T, Ikutani M, Takatsu K
    • Organizer
      第36回日本免疫学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20061200
  • [Presentation] Ag85B由来Peptide-25によるクロスプライミング増強効果の解析2006

    • Author(s)
      刈米アイ、田村敏生、高津聖志
    • Organizer
      第36回日本免疫学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20061200
  • [Presentation] Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment2006

    • Author(s)
      Nagai Y, Garrett KP, Ohta S, Bahrun U, Kouro T, Akira S, Takatsu K, Kincade PW
    • Organizer
      第36回日本免疫学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20061200
  • [Presentation] Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment2006

    • Author(s)
      Nagai Y, Garrett KP, Ohta S, Bahrun U, Kouro T, Akira S, Takastu K, Kincade PW
    • Organizer
      A Joint Meeting of the Society of Leukocyte Biology and the International Endotoxin and Innate Immunity Society
    • Place of Presentation
      San Antonio, TX
    • Year and Date
      20061100
  • [Presentation] Prospective isolation of human eosinophil lineage-commitment progenitors revealed that the eosinophil differentiation pathway is different in human and mouse hematopoiesis2006

    • Author(s)
      Mori Y, Iwasaki H, Yoshimoto G, Okeda A, Miyamoto T, Mizuno S, Harada M, Takatsu K, Akashi A
    • Organizer
      Am. Soc. Hematol
    • Place of Presentation
      San Antonio, TX
    • Year and Date
      20061100
  • [Presentation] Immunobiology of Ag85B and Peptide-25 of Mycobacterium tuberculosis2006

    • Author(s)
      Takatsu, K
    • Organizer
      8th Awaji Forum on Infection and Immunity
    • Place of Presentation
      Awaji Island
    • Year and Date
      20060900
  • [Presentation] Ag85B and its peptide of Mycobacterium tuberculosis as a potent immunomodulator: Robust induction of Th1 response and cross-priming2006

    • Author(s)
      Takatsu, K
    • Organizer
      The 13th East Asian Joint Symposium-From Genes to Therapeutics
    • Place of Presentation
      Seoul
    • Year and Date
      20060700
  • [Presentation] Ag85Bとそのペプチドによる免疫制御 : Th1誘導とクロスプライミング増強2006

    • Author(s)
      高津聖志
    • Organizer
      第34回BCG・BRM療法研究会
    • Place of Presentation
      東京
    • Year and Date
      20060700
  • [Presentation] Role of Toll-like receptor in the induction of activation-induced cytidine deaminase(AID)and class switch recombination Immunology 20062006

    • Author(s)
      Takatsu K, Tsukamoto Y, Kaisho M
    • Organizer
      AAI Annual Meeting
    • Place of Presentation
      Boston MA
    • Year and Date
      20060500
  • [Presentation] TCRシグナルを介するTh1分化における転写因子T-betの役割 : T-betノックアウトマウスを用いた解析2005

    • Author(s)
      下袴田陽子、徳永岳史、仲田真己代、有賀晴之、刈米アイ、田村敏生、高津聖志
    • Organizer
      第35回日本免疫学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      20051200
  • [Book] TLRシグナルとクラススイッチ組換え臨床免疫・アレルギー科492008

    • Author(s)
      長井良憲, 塚本裕美子, 高津聖志
    • Total Pages
      246-251
    • Publisher
      科学評論社
  • [Book] Ag85BによるTh1誘導と免疫腑活活性、MINOPGAGEN MEDICAL REVIEW 522007

    • Author(s)
      高津聖志
    • Total Pages
      65-80
    • Publisher
      ミノファーゲン製薬
  • [Book] IL-5ものがたり(連載第3回)、感染・炎症・免疫、362006

    • Author(s)
      高津聖志
    • Total Pages
      42-57
    • Publisher
      医薬の門社
  • [Book] 7サイトカイン、予防医学事典(松島剛治、酒井敏行、石川昌、稲寺秀邦編)2005

    • Author(s)
      高津聖志
    • Total Pages
      16-23
    • Publisher
      朝倉書店
  • [Book] タンパク質実験のための抗体実験マニュアル(実験医学別冊)(高津聖志、三宅健介、山元弘、瀧信介編)(基礎科学を支える研究ツールとしての抗体に関する基礎知識)2004

    • Author(s)
      小池正道、高津聖志
    • Total Pages
      12-17
    • Publisher
      羊土社
  • [Book] インターロイキン5、サイトカイン・ケモカインのすべて(笠倉新平、松島綱治編)2004

    • Author(s)
      高津聖志
    • Total Pages
      128-141
    • Publisher
      日本医学館

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Published: 2010-06-10   Modified: 2016-04-21  

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