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2006 Fiscal Year Final Research Report Summary

Physiological functions and underlying cellular/molecular mechanisms of retrograde inputs from higher cortical areas toe sensory cortices

Research Project

Project/Area Number 16200023
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionNiigata University

Principal Investigator

SHIBUKI Katsuei  Niigata University, Brain Res. Institute, Dept of Neurophysiology, Professor (40146163)

Co-Investigator(Kenkyū-buntansha) MUDOH Masaharu  Niigata University, Brain Res. Institute, Dept of Neurophysiology, Associate Professor (80153310)
HISHIDA Ryuichi  Niigata University, Brain Res. Institute, Dept of Neurophysiology, Assistant (90313551)
Project Period (FY) 2004 – 2006
KeywordsFlavoprotein fluorescence / Functional brain imaging / Auditory cortex / Missing fundamentals / Visual cortex / Squint / Transcranial imaging / Mouse
Research Abstract

Using transcranial flavoprotein fluorescence imaging in mice, the following results have been obtained.
1. We investigated auditory cortical plasticity regulated by acoustic environments. Mice were reared in various acoustic environments for at least 4 weeks after birth. Cortical responses elicited by tonal stimuli (5, 10 and 20 kHz) exhibited tonotopic maps in the primary auditory cortex (AI). Depression of auditory cortical responses was observed in sound-deprived mice compared with naive mice reared in a normal acoustic environment. When mice were exposed to an environmental tonal stimulus at 10 kHz for more than 4 weeks after birth, the cortical responses were potentiated in a frequency-specific manner. These results suggest that acoustic environments regulate the development of intracortical circuits in the mouse auditory cortex.
2. We visualized cortical responses to missing fundamentals in mice. The activity patterns in AI elicited by 5 kHz were different from those elicited by 20 … More kHz or 25 kHz. However, the areas activated by 5 kHz were also activated by the mixture of 20 kHz plus 25 kHz but not by that of 19 kHz plus 26 kHz, suggesting that cortical responses to missing fundamentals in AI were visualized using flavoprotein fluorescence imaging
3. Experience-dependent plasticity in the visual cortex was investigated. After monocular deprivation (MD) of 4 days starting from P28, deprived eye responses were suppressed compared to non-deprived eye responses in the binocular zone, but not in the monocular zone. Imaging faithfully recapitulated a critical period for plasticity with maximal effects of MD observed around P28 and not in adulthood even under urethane anesthesia. These results indicate that transcranial flavoprotein fluorescence imaging is a powerful tool for investigating experience-dependent plasticity in the mouse visual cortex.
4. We designed a hemilateral prism goggle for mice. This goggle was attached on the skull of mice during the critical period. The visual cortical responses elicited via the eye with a prism were significantly suppressed compared with those elicited via the contralateral normal eye. However, this suppression was not observed in mice, in which whiskers were trimmed. It was suggested that the visual responses might be suppressed by multimodal sensory mismatching between somatosensory inputs and visual inputs regarding spatial recognition. Less

  • Research Products

    (23 results)

All 2007 2006 2004

All Journal Article (21 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Experience-dependent formation of activity propagation patterns at the somatosensory S1 and S2 boundary in rat cortical slices2007

    • Author(s)
      Kamatani, D., Hishida, R., Kudoh, M, & Shibuki, K.
    • Journal Title

      Neuroimage 35

      Pages: 47-57

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Functional local connections with differential activity-dependence and critical periods surrounding the primary auditory cortex in rat cerebral slices2007

    • Author(s)
      Hishida, R., Karoatani, D., Kitaura, H., Kudoh, M.& Shibuki, K.
    • Journal Title

      Neuroimage 34

      Pages: 679-693

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Experience-dependent formation of activity propagation patterns at the somatosensory Si and S2 boundary in rat cotical slices.2007

    • Author(s)
      Kamatani D, Hishida R, Kudoh M, Shibulci K
    • Journal Title

      Neurolinage 35

      Pages: 45-57

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Functional local connections with differential activity -dependence and critical periods surrounding the primary auditory cortex in rat cerebral slices.2007

    • Author(s)
      Hishida R, Kamatani D, Kitaura H, Kudoh M, Shibuki K
    • Journal Title

      Neuroimage 34

      Pages: 679-693

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Coupling of brain function and metabolism : Endogenous flavoprotein fluorescence imaging of neural activities by local changes in energy metabolism.2007

    • Author(s)
      Shibuki K, Hishida R, Kitaura H, Takahashi K, Tohroi M
    • Journal Title

      In Handbook of Neurochemistry & Molecuiar Neurobiology. 3rd Edition, Neural Energy Utilization(Gibson C and Dienel C, ed). Springer New York Vol.5

      Pages: 322-342

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Requirement of the auditory association cortex for discrimination of vowel-like sounds in rats2006

    • Author(s)
      Kudoh, M., N.Nakayama, Y., Hishida, R.& Shibuki, K
    • Journal Title

      Neuroreport 17

      Pages: 1761-1766

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Sound sequence discrimination learning motivated by reward requires dopaminergic D2 receptor activation in the rat auditory cortex2006

    • Author(s)
      Kudoh, M.& Shibuki, K.
    • Journal Title

      Learn.Men 13

      Pages: 690-698

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Enduring critical period plasticity visualized by transcranial flavoprotein imaging in mouse primary visual cortex2006

    • Author(s)
      Tohmi, M., Kitaura, H., Komagata, S., Kudoh, M.& Shibuki, K.
    • Journal Title

      J.Neurosci 26

      Pages: 11775-11785

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Roles of the auditory cortex in discrimination learning by rats2006

    • Author(s)
      Ono, K., Kudoh, M.& Shibuki, K.
    • Journal Title

      Eur.J.Neurosci 23

      Pages: 1623-1632

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Transcranial fluorescence imaging of auditory cortical plasticity regulated by acoustic environments in mice2006

    • Author(s)
      Takahashi, K., Hishida, R., Kubota, Y., Kudoh, M., Takahashi, S., & Shibuki, K.
    • Journal Title

      Eur.J.Neurosci 23

      Pages: 1265-1276

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Transcranial imaging of audiogenic epileptic foci in the cortex of DBA/2J mice2006

    • Author(s)
      Takao, T., Murakami, H., Fukuda, M., Kawaguchi, T., Kakita, A., Takahashi, H, Kudoh, M., Tanaka, R.& Shibuki, K.
    • Journal Title

      Neuroreport 17

      Pages: 267-271

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Endogenous fluorescence imaging of somatosensory cortical activities after discrimination learning in rats2006

    • Author(s)
      Shibuki, K., Ono, K., Hishida, R.& Kudoh, M.
    • Journal Title

      Neuroimage 30

      Pages: 735-744

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Enduring critical period plasticity visualized by transcranial flavoprotein imaging in mouse primary visual cortex.2006

    • Author(s)
      Tohnil M, Kitaura H, Komagata S, Kudoh M, Shibuki K
    • Journal Title

      Jneurosci 26

      Pages: 11775-11785

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Requirement of the auditory association cortex for discrimination of vowel-like sounds in rats.2006

    • Author(s)
      Kudoh M, Nakayama Y, Hishida R, Shibuki K
    • Journal Title

      Neuroreport 17

      Pages: 1761-1766

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Sound sequence discrimination learning motivated by reward requires dopaminergic D2 receptor activation in the rat auditory cortex.2006

    • Author(s)
      Kudoh M, Shibuki K
    • Journal Title

      Learn Men 13

      Pages: 690-698

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Roles of the auditory cortex in discrimination learning by rats.2006

    • Author(s)
      Ono K, Kudoh M, Shibiiki K
    • Journal Title

      Eur JNeurosci 23

      Pages: 1623-1632

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Transcranial fluorescence imaging of auditory cortical plasticity regulated by acoustic environments in mice.2006

    • Author(s)
      Takaliashi K, Hishida R, Kubota Y, Kudoh M, Talcahashi S, Shibuki K
    • Journal Title

      Eur J Neurosci 23

      Pages: 1265-1276

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Transcranial imaging of audiogenic epileptic foci in the cortex of DBAI2J mice.2006

    • Author(s)
      Takao T, Murakami H, Fukuda M, Kawaguchi T, Kakita A, Takahashi H, Kudoh M, Tanaka R, Shibuki K
    • Journal Title

      Neuroreport 17

      Pages: 267-271

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Endogenous fluorescence imaging of somatosensory cortical activities after discrimination learning in rats.2006

    • Author(s)
      Shibulci K, Ono K, Hishida R, Kudoh M
    • Journal Title

      Neuroimage 30

      Pages: 735-744

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Learning of sound sequence discrimination dependent on cholinergic inputs to the rat auditory cortex2004

    • Author(s)
      Kudoh, M., Seki, K, & Shibuki, K.
    • Journal Title

      Neurosci.Res. 50

      Pages: 113-123

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Learning on sound sequence discrimination dependent on cholinergic inputs to the rat auditory cortex.2004

    • Author(s)
      Kudoh M, Seki K, Shibuki K
    • Journal Title

      Neurosci.Res. 50

      Pages: 113-123

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] energy metabolism.In Handbook of Neurochemistry & Molecular Neurobiology.3rd Edition, Vol.5, Neural Energy Utilization (Gibson G and Dienel G, ed), Springer,New York2007

    • Author(s)
      Shibuki, K., Hishida, R., Kitaura, H., Takahashi, K.& Tohmi, M.
    • Total Pages
      924(うち 322-342)
    • Publisher
      Coupling of brain function and metabolism:Endogenous flavoprotein fluorescence imaging of neural activities by local changes in energy metabolism. In Handbook ofNeurochemistry & Molecular Neurobiology. 3rd Edition,Nol.5, Neural Energy Utilization (Gibson G and Dienel G, ed)
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] 学習機能障害評価方法, 及びその学習機能障害評価用装置2004

    • Inventor(s)
      工藤 雅治, 澁木 克栄
    • Industrial Property Rights Holder
      新潟TLO
    • Industrial Property Number
      特願番号:2004-258941
    • Filing Date
      2004-09-06
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-02-04  

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