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2007 Fiscal Year Final Research Report Summary

Domain mapping of glial origin … Cell biological basis of glial diversity

Research Project

Project/Area Number 16200028
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

IKENAKA Kazuhiro  National Institute for Physiological Sciences, Molecular Physiology, Professor (00144527)

Co-Investigator(Kenkyū-buntansha) ONO Katsuhiko  National Institute for Physiological Sciences, Molecular Physiology, Associate Professor (30152523)
SEIJI Hitoshi  National Institute for Physiological Sciences, Molecular Physiology, Associate Professor (70300895)
TAKEBAYASHI Hirohide  National Institute for Physiological Sciences, Molecular Physiology, Assistant Professor (60353439)
Project Period (FY) 2004 – 2007
KeywordsOlig2 / astrocyte / oligodendrocyte / Cre / loxP / tamoxifen / forebrain / GLAST / PDGFa receptor
Research Abstract

We analyzed fates of Olig2 progenitor cells in the forebrain using tamoxifen inducible Cre/loxP system. Tamoxifen was injected to the E 13.5 dams to induce Cre-mediated recombination to label Olig2+ cells and animals were analyzed at E16.5. Approximately 60% of GFP+/Olig2+ cells were positive for GLAST, a marker for astrocyte progenitor cells, in the cortex, and 40% of these cells were positive for PDGFα receptor, a marker for oligodendrocyte progenitor cells. In addition, 9% of GFP+/Olig2+ cell population were immunopositive for class DI β tubulin, a marker for immature neurons. The above value suggests the presence of cells co-expressing both progenitor markers, which is supported by the observation that approximately 15% of GLAST+ cells co-expressed PDGFRα and vice versa in the late fetal stage. Therefore, Olig2+ cells in the late fetal stages were mixed population of glial progenitor cells : The number of astrocyte progenitor cells, which expressed GLAST or FGF receptor 3, decreased in the Olig2 deficient mouse cortex, while that in the knockout basal forebrain was unchanged. Oligodendrocyte progenitor cells were missing almost completely in the Olig2 deficient forebrain, as previously reported. These results indicate that Olig2 is essential for oligodendrocyte genesis and also that it plays some roles in astrocytogenesis in a region-specific manner.

  • Research Products

    (129 results)

All 2009 2008 2007 2006 2005 2004

All Journal Article (43 results) (of which Peer Reviewed: 22 results) Presentation (86 results)

  • [Journal Article] An animal model for late onset chronic demyelination disease caused by failed terminal differentiation of oligodendrocytes2009

    • Author(s)
      Ma J, et. al.
    • Journal Title

      Neuron Glia 2

      Pages: 81-91

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Murine model of Alexander disease:analysis of GFAP aggregate formation and its pathological significance2007

    • Author(s)
      Tanaka KF, et. al.
    • Journal Title

      Glia 55

      Pages: 617-631

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Regulation of glial development by cystatin C2007

    • Author(s)
      Hasegawa A, et. al.
    • Journal Title

      J Neurochem 100

      Pages: 12-22

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Induced expression of cathepsins and cystatin C in a murine model of demyelination2007

    • Author(s)
      Ma J, et. al.
    • Journal Title

      Neurochem Res 32

      Pages: 311-320

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress2007

    • Author(s)
      Hitoshi S, et. al.
    • Journal Title

      J Neurosci Res 85

      Pages: 3574-3585

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Murine model ofAlexander disease : analysis of GFAP aggregate formation and its pathological significance.2007

    • Author(s)
      Tanaka KF, et. al.
    • Journal Title

      Glia 55

      Pages: 617-631

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Regulation of glial development by cystatin C.2007

    • Author(s)
      Hasegawa A, et. al.
    • Journal Title

      J Neurochem 100

      Pages: 12-12

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Induced expression of cathepsins and cystatin C in a murine model of demyelination.2007

    • Author(s)
      Ma J, et. al.
    • Journal Title

      Neurochem Res 32

      Pages: 311-320

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress.2007

    • Author(s)
      Hitoshi S, et. al.
    • Journal Title

      J Neurosci Res 85

      Pages: 3574-3585

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dorsally derived netrin-1 provides an Inhibitory cue & elaborates the "waiting period" for primary sensory axons in the developing spinal cord2006

    • Author(s)
      Watanabe K, et. al.
    • Journal Title

      Development 133

      Pages: 1379-1386

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Direct evidence that ventral forebrain cells migrate to the cortex and contribute to the generation of cortical myelinating oligdendrocytes2006

    • Author(s)
      Nakahira E, et. al.
    • Journal Title

      Dev Biol 291

      Pages: 123-131

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] An animal model for late onset chronic demyelination disease caused by failed terminal differentiation of oligodendrocytes2006

    • Author(s)
      Ma J, et. al.
    • Journal Title

      Neuron Glia Biol 2

      Pages: 81-91

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Involvement of the Olig2 transcription factor in cholinergic neuron development of the basal forebrain2006

    • Author(s)
      Furusho M, et. al.
    • Journal Title

      Dev Biol 293

      Pages: 348-357

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Olig2-positive progenitors in the embryonic spinal cord give rise to not only to motoneurons and oligodendrocytes,but also to a subset of astrocytes and ependymal cells2006

    • Author(s)
      Masahira N, et. al.
    • Journal Title

      Dev Biol 293

      Pages: 358-369

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Fluoro-Jade:New fluorescent marker of Rosenthal fibers2006

    • Author(s)
      Tanaka KF, et. al.
    • Journal Title

      Neurosci Lett 407

      Pages: 127-130

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Electrophysiological abnormality precedes apparent histological demyelination in the Central Nervous System of mice over-expressing proteolipid protein2006

    • Author(s)
      Tanaka H, et. al.
    • Journal Title

      J Neurosci Res 84

      Pages: 1206-1216

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Induction of oligodendrocyte progenitors in dorsal forebrain by intraventricular microinjection of FGF-22006

    • Author(s)
      Naruse M, et. al.
    • Journal Title

      Dev Biol 297

      Pages: 262-273

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Expression of the basic helix-loop-helix factor Olig2 in the developing retina:Olig2 as a new marker for retinal progenitors and late-born cells2006

    • Author(s)
      Shibasaki K, et. al.
    • Journal Title

      Gene Expression Patterns 7

      Pages: 57-65

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Dorsally derived netrin1 provides an Inhibitory cue & elaborates the waiting period for primary sensory axons in the developing spinal cord.2006

    • Author(s)
      Watanabe K, et. al.
    • Journal Title

      Development 133

      Pages: 1379-1386

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Direct evidence that ventral forebrain cells migrate to the cortex and contribute to the generation of cortical myelinating oligdendrocytes.2006

    • Author(s)
      Nakahira E, et. al.
    • Journal Title

      Dev Biol 271

      Pages: 123-131

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Involvement of the Olig2 transcription factor in cholinergic neuron development of the basal forebrain.2006

    • Author(s)
      Furusho M, et. al.
    • Journal Title

      Dev Biol 293

      Pages: 348-357

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Olig2-positive progenitors in the embryonic spinal cord give rise to not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells.2006

    • Author(s)
      Masahira N, et. al.
    • Journal Title

      293

      Pages: 358-369

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Fluoro-Jade : New fluorescent marker of Rosenthal fibers.2006

    • Author(s)
      Tanaka KF, et. al.
    • Journal Title

      Neurosci Lett 407

      Pages: 127-130

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Electrophysiological abnormality precedes apparent histological demyelination in the Central Nervous System of mice over-expressing proteolipid protein.2006

    • Author(s)
      Tanaka H, et. al.
    • Journal Title

      J Neurosci Res 84

      Pages: 1206-1216

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Induction of oligodendrocyte progenitors in dorsal forebrain by intraventricular microinjection of FGF 2.2006

    • Author(s)
      Naruse M, et. al.
    • Journal Title

      Dev Biol 297

      Pages: 262-273

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression of the bssic helirloop-helix factor Olig2 in the developing retina : Olig2 as a new marker for retinal progenitors and late-born cells.2006

    • Author(s)
      Shibasaki K, et. al.
    • Journal Title

      Gene Expression Patterns 7

      Pages: 57-65

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Short-term Lineage analysis of dorsally derived Olig3 cells in the developing spinal cord2005

    • Author(s)
      Ding L, et. al.
    • Journal Title

      Dev Dynamics 234

      Pages: 622-632

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Gliogenic radial glial cells show heterogeneity in the developing mouse spinal cord2005

    • Author(s)
      Ogawa Y, et. al.
    • Journal Title

      Dev Neurosci 27

      Pages: 364-377

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Wnt signaling controls the timing of oligodendrocyte development in the spinal cord2005

    • Author(s)
      Shimizu T, et. al.
    • Journal Title

      Dev Biol 282

      Pages: 397-410

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Improved preservation of X-gal reaction product for electron microscopy using hydroxypropyl methacrylate2005

    • Author(s)
      Masahira N, et. al.
    • Journal Title

      Neurosci Lett 374

      Pages: 17-20

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Short-term Lineage analysis of dorsally derived Olig3 cells in the developing spinal cord.2005

    • Author(s)
      Ding L, et. al.
    • Journal Title

      Dev Dynamics 234

      Pages: 622-632

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Gliogenic radial glial cells show heterogeneity in the developing mouse spinal cord.2005

    • Author(s)
      Ding L, et. al.
    • Journal Title

      Dev Neurosci 27

      Pages: 364-377

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Wnt signaling controls the timing of oligodendrocyte development in the spinal cord.2005

    • Author(s)
      Shimizu T, et. al.
    • Journal Title

      Dev Biol 282

      Pages: 397-410

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Improved preservation of X-gal reaction product for electron microscopy using hydroxypropyl methacrylate.2005

    • Author(s)
      Masahira N, et. al.
    • Journal Title

      Neurosci Lett 374

      Pages: 17-20

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Lower rhombic lip-derived cells undergo transmedian tangential migration followed by radial migrati on in the chick embryo brainstem2004

    • Author(s)
      Ono K, et. al.
    • Journal Title

      Eur J Neurosci 20

      Pages: 914-922

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Isolation of cystatin C via functional cloning of astrocyte differentiation factors2004

    • Author(s)
      Kumada T, et. al.
    • Journal Title

      Dev Neurosci 26

      Pages: 68-76

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Conduction properties of identified neural pathways in the central nervous system of mice in vivo2004

    • Author(s)
      Tanaka H, et. al.
    • Journal Title

      Neurosci Res 49

      Pages: 113-122

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Mossy fiber contact triggers the targeting of Kv4.2 potassium channels to dendrites and synapses in developing cerebellar granule neurons2004

    • Author(s)
      Shibasaki K, et. al.
    • Journal Title

      J Neurochem 89

      Pages: 897-907

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation2004

    • Author(s)
      Ishibashi T, et. al.
    • Journal Title

      J Neurosci 24

      Pages: 96-102

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Lower rhombic lip-derived cells undergo transmedian tangential migration followed by radial migration in the chick embryo brainstem.2004

    • Author(s)
      Ono K, et. al.
    • Journal Title

      Eur J Neurosci 20

      Pages: 914-922

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Isolation of cystatin C via functional cloning of astrocyte differentiation factors.2004

    • Author(s)
      Kumada T, et. al.
    • Journal Title

      Dev Neurosci 26

      Pages: 68-76

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Mossy fiber contact triggers the targeting of Kv4.2potassium channels to dendrites and synapses in developing cerebellar granule neurons.2004

    • Author(s)
      Shibasaki K, et. al.
    • Journal Title

      J Neurochem 89

      Pages: 897-907

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation.2004

    • Author(s)
      Ishibashi T, et. al.
    • Journal Title

      J Neurosci 24

      Pages: 96-102

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] ニワトリ胚への新規遺伝子導入法を用いた領域特異的な恒久遺伝子発現2008

    • Author(s)
      後藤 仁
    • Organizer
      神経発生討論会
    • Place of Presentation
      岡崎
    • Year and Date
      2008-03-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Permanent labeling of glial cell lineage through a combination method of electroporation and viral infection.2008

    • Author(s)
      Gotoh, H., et. al.
    • Organizer
      Okazaki Neural Developing Meeting
    • Place of Presentation
      Okazaki
    • Year and Date
      2008-03-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Paradoxial neuron differentiation of olig2+ progenitors into branchiomotor/visceromotor neurons2007

    • Author(s)
      Ono K, et. al.
    • Organizer
      IBRO satellite;Stem Cells, Migration and Axon Guidance Meeting
    • Place of Presentation
      Cairns,Australia
    • Year and Date
      20070709-11
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Paradoxial neuron differentiation of olig2+progenitors into branchiomotor/visceromotor neurons.2007

    • Author(s)
      Ono K, et. al.
    • Organizer
      IBRO satellite ; Stem Cells, Migration and Axon Guidance Meeting
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      20070709-11
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Mood stabilizing drugs expand neural stem cell pool in the adult brain by activating notch signaling2007

    • Author(s)
      Higashi M, et. al.
    • Organizer
      5th International Society for Stem Cell Research
    • Place of Presentation
      Cairns,Australia
    • Year and Date
      20070611-14
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Mood stabilizing drugs expand neural stem cell pool in the adult brain by activating notch signaling.2007

    • Author(s)
      Higashi M, et. al.
    • Organizer
      5th International Society for stem Cell Research
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      20070611-14
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Difference in the differentiation potential between Nestin+ and Olig2+ cells in embryonic ventralforebrain2007

    • Author(s)
      Naruse M, et. al.
    • Organizer
      Society for Neuroscience 37th Annual Meeting
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Difference in the differentiation potential between Nestin+ and Olig2+ cells in embryonic ventralforebrain2007

    • Author(s)
      Naruse M, et. al.
    • Organizer
      Society for Neuroscience 37th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Glial cells missing genes in the induction of neural stem cells from primitive neural stem cells2007

    • Author(s)
      Hitoshi S, et. al.
    • Organizer
      Society for Neuroscience 37th Annual Meeting
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Glial cells missing genes in the induction of neural stem cells from primitive neural stem cells.2007

    • Author(s)
      Hitoshi S, et. al.
    • Organizer
      Society for Neuroscience 37th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Olig genes and oligodendrocyte development2007

    • Author(s)
      Takebayashi H, et. al.
    • Organizer
      The APSN symposium on "Glial Activation and Function"
    • Place of Presentation
      Dalian,China
    • Year and Date
      2007-10-19
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Olig genes and oligodendrocyte development.2007

    • Author(s)
      Takebayashi H, et. al.
    • Organizer
      The APSN symposium on Glial Activation and Function
    • Place of Presentation
      Dalian, China
    • Year and Date
      2007-10-19
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] アレキサンダー病モデルマウスの解析2007

    • Author(s)
      李 海雄, 他
    • Organizer
      第50回日本神経化学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Cystaitn Cによるグリア細胞分化制御2007

    • Author(s)
      成瀬 雅衣
    • Organizer
      第50回日本神経化学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Analysis of Alexander disease model mice2007

    • Author(s)
      Lee HU, et. al.
    • Organizer
      The Japanese society for Neurochemistry, 49th Annual Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-09-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Cystatin C regulated glial diffrerentiation.2007

    • Author(s)
      Naruse M, et. al.
    • Organizer
      The Japanese society for Neurochemistry, 49th Annual Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-09-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Changes in the character of microglia coincide with the impaired remyelination by oligodendrocytes2007

    • Author(s)
      Ikenaka K
    • Organizer
      ISN Myelin Development & Function Conference
    • Place of Presentation
      Chichen-itza,Mexico
    • Year and Date
      2007-08-17
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Changes in the character of microglia coincide with the impaired remyelination by oligodendrocytes.2007

    • Author(s)
      Ikenaka K
    • Organizer
      ISN Myelin Development & FunctionConference
    • Place of Presentation
      Chichen-itza, Mexico
    • Year and Date
      2007-08-17
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 前脳におけるOlig2系譜細胞の分化様式2007

    • Author(s)
      小野 勝彦, 他
    • Organizer
      第112回日本解剖学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-28
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Lineage analysis of Olig2+cells in the forebrain2007

    • Author(s)
      Ono K, et. al.
    • Organizer
      The Japanese association of Anatomists, 112th Annual meeting
    • Place of Presentation
      Osaka
    • Year and Date
      2007-03-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Neuronal and glial differentiation of Olig2-positiveprogenitors with a stage-specific manner in the mouse forebrain2006

    • Author(s)
      Ono K, et. al.
    • Organizer
      Cold Spring Harbor Laboratory meeting;Axon guidance, Synaptogenesis, & Neural Plasticity
    • Place of Presentation
      Cold Spring Harbor,USA
    • Year and Date
      20060914-16
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Neuronal and glial differentiation of Olig2-positive progenitors with a stage-specific manner in the mouse forebrain.2006

    • Author(s)
      Ono K, et. al.
    • Organizer
      Cold Spring Harbor Laboratory meeting ; Axon guidance, Synaptogenesis, & Neural Plasticity
    • Place of Presentation
      Cold Spring Harbor, USA
    • Year and Date
      20060914-16
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Induction of oligodendrocyte precursors in fetal cerebral cortex by intraventricular injection of FGF-22006

    • Author(s)
      Naruse M, et. al.
    • Organizer
      16th Biennial Meeting of the International Society for Developmental Neuroscience
    • Place of Presentation
      Banff,Canada
    • Year and Date
      20060824-28
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Induction of oligodendrocyte precursors in fetal cerebral cortex by intraventricular injection of FGF-2.2006

    • Author(s)
      Naruse M, et. al.
    • Organizer
      16th Biennial Meeting of the International Society for Developmental Neuroscience
    • Place of Presentation
      Banff, Canada
    • Year and Date
      20060824-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] An improved method to determine N-linked sugar chain structure from pmol level of glycoproteins2006

    • Author(s)
      Ikenaka K
    • Organizer
      The 2nd ISN Special Neurochemistry Conference on Neural Glycoproteins and Glycolipids
    • Place of Presentation
      Antigua,west Indies
    • Year and Date
      2006-12-02
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] An improved method to determine N-linked sugar chain structure from pmol level of glycoproteins.2006

    • Author(s)
      Ikenaka K
    • Organizer
      The 2nd ISN Special Neurochemistry Conference on Neural Glycoproteins and Glycolipids
    • Place of Presentation
      Antigua, west Indies
    • Year and Date
      2006-12-02
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Changes in the character of microglia coincide with the impaired remyelination by oligodendrocytes2006

    • Author(s)
      Ikenaka K
    • Organizer
      Round table of the ESF Marie network on:"Myelin structure and its role in autoimmunity"
    • Place of Presentation
      Bari,Italy
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Changes in the character of microglia coincide with the impaired remyelination by oligodendrocytes.2006

    • Author(s)
      Ikenaka K.
    • Organizer
      Round table of the ESF Marie network on : Myelin structure and its role in autoimmunity
    • Place of Presentation
      Bari, Italy
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Change in the character of microglia coincide with the impaired remyelination by oligodendrocytes.2006

    • Author(s)
      Ikenaka K, et. al.
    • Organizer
      The Japan Neuroscience society 29th Annual Meeting
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-09-21
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Olig2 lineage cells differenciate into neuron, astrocyte and oligoden drocyte in a spatio-temporal dependent manner.2006

    • Author(s)
      Ono K, et. al.
    • Organizer
      The Japanese society for 29th Annual Meeting
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-09-20
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Lineage analysis of Olig2-expressing cell in the mouse caudal brainstem2006

    • Author(s)
      Ikeda K, et. al.
    • Organizer
      第49回日本神経化学会大会合同年会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-09-16
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Dynamics of neural stem cells in the adult mammalian brain under stress conditions2006

    • Author(s)
      Hitoshi S., et. al.
    • Organizer
      第49回日本神経化学会大会合同年会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-09-16
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Leneage analysis ofOlig2-expressiong cell in the mouse caudal brainstem.2006

    • Author(s)
      Ikeda K, et. al.
    • Organizer
      The Japanese Society for Neurochemistry, 49th Annual Meeting
    • Place of Presentation
      Nagoya
    • Year and Date
      2006-09-16
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Dynamics of nerural stem cells in the adult mammalian brain under stress conditions.2006

    • Author(s)
      Hitoshi S, et. al.
    • Organizer
      The Japanese Society for Neurochemistry, 49th Annual Meeting
    • Place of Presentation
      Nagoya
    • Year and Date
      2006-09-16
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Change in the character of microglia coincide with the impaired remyelination by oligodendrocytes2006

    • Author(s)
      Ikenaka K, et. al.
    • Organizer
      The 2006 meeting on Glia in Health & Disease.Cold Spring Harbor Laboratory.
    • Place of Presentation
      Cold Spring Harbor,USA
    • Year and Date
      2006-07-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Abnormalities found in Alexander disease-model mouse2006

    • Author(s)
      Tanaka KF, Ikenaka K
    • Organizer
      The 2006 meeting on Glia in Health & Disease.Cold Spring Harbor Laboratory.
    • Place of Presentation
      Cold Spring Harbor,USA
    • Year and Date
      2006-07-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Abnormalities found in Alexander disease-model mouse.2006

    • Author(s)
      Tanaka KF, Ikenaka K
    • Organizer
      The 2006 meeting on Glia in Health & Disease.Cold Spring Harbor Laboratory.
    • Place of Presentation
      Cold Spring Harbor, USA
    • Year and Date
      2006-07-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 前脳におけるOlig2細胞の系譜解析-2:Olig2発現細胞はニューロン,オリゴデンドロサイト,アストロサイトが時期依存的に分化する2006

    • Author(s)
      小野 勝彦
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Year and Date
      2006-07-21
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 胎仔期脊髄においてNetrin-1はOlig3系譜細胞の腹側方向への移動を制御する2006

    • Author(s)
      渡辺 啓介, 他
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Year and Date
      2006-07-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Cystatin F induction in demyelinating disease of CNS2006

    • Author(s)
      Ma J, et. al.
    • Organizer
      7th Biennial Meeting of the APSN
    • Place of Presentation
      Singapore
    • Year and Date
      2006-07-05
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Cystatin F induction in demyelinating disease of CNS.2006

    • Author(s)
      Ma J, et. al.
    • Organizer
      7th Biennial Meeting of the APSN
    • Place of Presentation
      Singapore
    • Year and Date
      2006-07-05
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Netrin 1 is required forformation of the dorsal spinal cord2006

    • Author(s)
      Watanabe K, et. al.
    • Organizer
      7th Biennial Meeting of the APSN
    • Place of Presentation
      Singapore
    • Year and Date
      2006-07-05
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Stage-specific defferentiation of olig2-expressing cells in the mouse brainstem2006

    • Author(s)
      Ikeda K, et. al.
    • Organizer
      7th Biennial Meeting of the APSN
    • Place of Presentation
      Singapore
    • Year and Date
      2006-07-04
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Netrin 1 is required for formation of the dorsal spinal cord2006

    • Author(s)
      Watanabe K, et. al.
    • Organizer
      7th Biennial Meeting of the APSN
    • Place of Presentation
      Singapore
    • Year and Date
      2006-07-04
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Stage-specific defferentiation of olig2-expressing cells in the mouse brainstem.2006

    • Author(s)
      Ikeda K, et. al.
    • Organizer
      7th Biennial Meeting of the APSN
    • Place of Presentation
      Singapore
    • Year and Date
      2006-07-04
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Netrin 1 attracts dorsal Oig3 lineage cells.2006

    • Author(s)
      Watanabe K, et. al.
    • Organizer
      7th Biennial Meeting of the APSN
    • Place of Presentation
      Singapore
    • Year and Date
      2006-07-04
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Causes for the arrested oligodendrocyte development in demyelinating diseases2006

    • Author(s)
      Ikenaka K
    • Organizer
      American Society for Neurochemistry 35th Annual meeting
    • Place of Presentation
      Portland,USA
    • Year and Date
      2006-03-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Lineage Analysis of The Olig2 Expressing Cells in The Central Nervous System.2006

    • Author(s)
      Ono K
    • Organizer
      American Society for Neurochemistry 35th Annual meeting
    • Place of Presentation
      Portland, USA
    • Year and Date
      2006-03-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Lineage analysis of the Olig2 expressing cells in the central nervous system2006

    • Author(s)
      Ono K
    • Organizer
      Myelin Gordon Conference
    • Place of Presentation
      Ventura,CA,USA
    • Year and Date
      2006-02-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Causes for the arrested oligodendrocyte development in demyelinating diseases.2006

    • Author(s)
      Ikenaka K
    • Organizer
      Myelin Gordon Conference
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2006-02-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Dynamics of neural stem cells under stress conditions2005

    • Author(s)
      Hitoshi S, et. al.
    • Organizer
      8th World Congress of Biological Psychiatry
    • Place of Presentation
      Vienna,Austria
    • Year and Date
      20050627-0704
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Dynamics of neural stem cells under stress conditions.2005

    • Author(s)
      Hitoshi S, et. al.
    • Organizer
      8th World Congress of Biological Psychiatry
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      20050627-0704
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Dorsally-derived Olig 3 lineage cells migrate ventrally and differentiate into commissural interneurons in the developing mouse spinal cord2005

    • Author(s)
      Ding L, et. al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington D.C.,U.S.A.
    • Year and Date
      2005-11-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] The process of Rosenthal fiber formation is dependent on both quality and quantity of GFAP2005

    • Author(s)
      Tanaka KF, et. al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington D.C.,U.S.A.
    • Year and Date
      2005-11-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Dorsally-derived Olig 3 lineage cells migrate ventrally and differentiate into commissural interneurons in the developing mouse spinal cord.2005

    • Author(s)
      Ding L, et. al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington D.C., U.S.A
    • Year and Date
      2005-11-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] The process of Rosenthal fiber formation is dependent on both quality and quantity of GFAE.2005

    • Author(s)
      Tanaka KF, et. al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington D.C., U.S.A
    • Year and Date
      2005-11-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Dorsally-derived netrin-1 is appropriate guidance of primary sensory axons in the developing spinal cord2005

    • Author(s)
      Watanabe K, et. al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington D.C.,U.S.A.
    • Year and Date
      2005-11-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Mood stabilizing drugs enhance adult neurogenesis activated by Notch signaling in the neural stem cell2005

    • Author(s)
      Higashi M, et. al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington D.C.,U.S.A.
    • Year and Date
      2005-11-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Dorsally-derived netrin-lis appropriate guidance of primary sensory axons in the developing spinal cord.2005

    • Author(s)
      Watanabe K, et. al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington D.C., U.S.A
    • Year and Date
      2005-11-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Mood stabilizing drugs enhance adult neurogenesis activated by Notch signaling in the neural stem cell.2005

    • Author(s)
      Higashi M, et. al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington D.C., U.S.A
    • Year and Date
      2005-11-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Induction of ectopic oligodendrocyte precursors in fetal cerebral cortex by intraventricular injection of FGF-22005

    • Author(s)
      成瀬 雅衣
    • Organizer
      第48回日本神経化学会
    • Place of Presentation
      福岡
    • Year and Date
      2005-09-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Dorsally derived netrin-1 controls axonal patterning of primary sensory axons in the developing spinal cord2005

    • Author(s)
      渡辺 啓介, 他
    • Organizer
      第48回日本神経化学会
    • Place of Presentation
      福岡
    • Year and Date
      2005-09-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Induction of ectopic oligodendrocyte precursors In fetal cerebral cortex by intraventricular injection of FGF-22005

    • Author(s)
      Naruse M, et. al.
    • Organizer
      The Japanese Society for Neurochemistry 48th Annual Meeting
    • Place of Presentation
      Fukuoka
    • Year and Date
      2005-09-29
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Alexander disease model mice2005

    • Author(s)
      田中 謙二
    • Organizer
      第48回日本神経化学会
    • Place of Presentation
      福岡
    • Year and Date
      2005-09-28
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Alexander disease model mice.2005

    • Author(s)
      Tanaka KF, et. al.
    • Organizer
      The Japanese Society for Neurochemistry, 48th Annual Meeting
    • Place of Presentation
      Fukuoka
    • Year and Date
      2005-09-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Dorsally derived netrion-1 control axonal patterning of primary sensory axons in the developing spinal cord.2005

    • Author(s)
      Watanabe K, et. al.
    • Organizer
      The Japanese Society for Neurochemistry, 48th Annual Meeting
    • Place of Presentation
      Fukuoka
    • Year and Date
      2005-09-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] マウス大脳発達におけるN-結合型糖蛋白質の糖鎖構造解析2005

    • Author(s)
      鳥居 知宏, 他
    • Organizer
      第69回日本生化学会中部支部例会
    • Place of Presentation
      名古屋
    • Year and Date
      2005-05-21
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] GPR35bの高分化型胃癌発生における,遺伝子発現形式の検討2005

    • Author(s)
      中島 弘文, 他
    • Organizer
      第69回日本生化学会中部支部例会
    • Place of Presentation
      名古屋
    • Year and Date
      2005-05-21
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Analysis of N-linked glycan structure expressed in developing mouse brain2005

    • Author(s)
      Toni T, et. al.
    • Organizer
      The Japanese Biochemical Society 69th Annual meeting
    • Place of Presentation
      Nagoya
    • Year and Date
      2005-05-21
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Expression of GPR35b during stomac cancer development.2005

    • Author(s)
      Nakajima H, et. al.
    • Organizer
      The Japanese Biochemical Society 69th Annual meeting
    • Place of Presentation
      Nagoya
    • Year and Date
      2005-05-21
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Mutated GFAP dynamics in mouse primary astrocytes2004

    • Author(s)
      Tanaka T, et. al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2004-10-23
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Olig2 positive cells differentiate into GABAergeic neurons and/or Oligodendrocyte progenitors in the forebrain2004

    • Author(s)
      Furusho M, et. al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2004-10-23
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Mutated GFAP dynamics in mouse primaryastrocytes.2004

    • Author(s)
      Tanaka T, et. al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, US
    • Year and Date
      2004-10-23
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Olig2 positive cells differentiate into GABAergeic neurons and/or Oligodendrocyte progenitors in the forebrain.2004

    • Author(s)
      Furusho M, et. al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, US
    • Year and Date
      2004-10-23
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] ネトリン1欠損マウス脊髄ではオリゴデンドロサイト前駆細胞の出現部位が腹側方向に変異する2004

    • Author(s)
      小野 勝彦, 他
    • Organizer
      第47回日本神経化学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2004-09-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 前脳のOlig2陽性細胞はGABA作動性ニューロンやオリゴデンドロサイト前駆細胞に分化する2004

    • Author(s)
      古性 美記, 他
    • Organizer
      第47回日本神経化学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2004-09-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] CreER^<TM>/loxPシステムを用いたOlig2発現細胞の細胞系譜解析2004

    • Author(s)
      政平 訓貴, 他
    • Organizer
      第47回日本神経化学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2004-09-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Notchシグナルによる未分化神経幹細胞から神経幹細胞への分化制御2004

    • Author(s)
      等 誠司, 他
    • Organizer
      第47回日本神経化学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2004-09-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Ventral shift of the site of oligodendorcyte origin in the Netrin-1 deficient mouse spinal cord.2004

    • Author(s)
      Ono K, et. al.
    • Organizer
      The Japanese Society for Neurochemistry, 47th Annual Meeting
    • Place of Presentation
      Osaka
    • Year and Date
      2004-09-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Olig2 positive cells differentiate into GABAergeic Neuron and/or Oligodendrocyte progenitors in the forebrain.2004

    • Author(s)
      Furusho M, et. al.
    • Organizer
      The Japanese Society for Neurochemistry, 47th Annual Meeting
    • Place of Presentation
      Osaka
    • Year and Date
      2004-09-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] A long-term lineage analysis of Olig2-expressing Cells by CreER^Tm/lixP system.2004

    • Author(s)
      Masahira N, et. al.
    • Organizer
      The Japanese Society for Neurochemistry, 47th Annual Meeting
    • Place of Presentation
      Osaka
    • Year and Date
      2004-09-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling2004

    • Author(s)
      Hitoshi S, et. al.
    • Organizer
      The Japanese Society for Neurochemistry, 47th Annual Meeting
    • Place of Presentation
      Osaka
    • Year and Date
      2004-09-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 脱随モデルマウスにおける脳内遺伝子変化の解析2004

    • Author(s)
      馬 堅妹, 他
    • Organizer
      第47回日本神経化学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2004-09-21
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] DNA microarray analysis of gene expression during Demyelination.2004

    • Author(s)
      Ma J, et. al.
    • Organizer
      The Japanese Society for Neurochemistry, 47th Annual Meeting
    • Place of Presentation
      Osaka
    • Year and Date
      2004-09-21
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Diversity of radial glial cells is formed along the dorso-ventral axis in the developing mouse spinal cord2004

    • Author(s)
      Ogawa, et. al.
    • Organizer
      American Society for Neurochemistry 35th annual Meeting
    • Place of Presentation
      New York,USA
    • Year and Date
      2004-08-16
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Diversity of radial glial cells is formed along the dorso-ventral axis in the developing mouse spinal cord2004

    • Author(s)
      Ogawa Y, et. al.
    • Organizer
      American Society for Neurochemistry 35th annual Meeting
    • Place of Presentation
      New York, USA
    • Year and Date
      2004-08-16
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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