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2006 Fiscal Year Final Research Report Summary

Development of a waveguide surface plasmon resonance biosensor fabricated by a polymer replication method

Research Project

Project/Area Number 16201030
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Microdevices/Nanodevices
Research InstitutionCorporate R&D Headquarters, OMRON Corporation (2006-2007)
Osaka University (2004-2005)

Principal Investigator

AOYAMA Shigeru  OMRON Corporation, Corporate Research and Development Headquarters, Advanced Device Laboratory, Core Group, Group Manager, 先端デバイス研究所コア技術グループ, 参事(研究職) (50362588)

Co-Investigator(Kenkyū-buntansha) YANAGIDA Toshio  Osaka University, Graduate School of Frontier Biosciences, Professor, 大学院生命機能研究科, 教授 (30089883)
Project Period (FY) 2004 – 2007
Keywordssurface plasmon resonance / waveguide / biosensor / imprint / polymer / polyethylene glycol / array / sensitivity domain
Research Abstract

Biosensors are currently used for the purpose of detecting protein-protein interactions. However, this sensor can be operated by experts who require an expensive and complicated optical system with unique technology at the laboratory level. Therefore, recently a waveguide surface plasmon resonance (WSPR) sensor that can integrate various optical functions has attracted attention. Moreover, we are developing imprint technology that can inexpensively produce fine structure with high precision.
In this research, a WSPR sensor was fabricated by polymer utilizing imprint technology. Compact and simple composition was enabled by changing a complicated optical system into an optical integrated circuit and integration on a plate using this imprint technology. A technique to transfer this integrated circuit on a glass substrate with imprint technology was developed, proving that an optical integrated circuit can be economically manufactured. Furthermore, a functional membrane for capturing a target protein to a sensor chip was developed. Improvements were also realized in the absolute quantity of target protein capture by the high-density of a functional membrane and in the rate that only catches a specific protein by improving the molecular bond structure of a functional membrane. Moreover, to prove its usefulness as a biosensor, the optimal structure design of a sensor chip was achieved, a sensor chip was produced using imprint technology, and the adsorption reaction of the model protein was detected using the sensor chip. The refractive-index resolution was 8.9x10^<-5> [RIU (refractive index unit)].

  • Research Products

    (14 results)

All 2006 2005 2004

All Journal Article (12 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Grafting of poly(ethylene glycol) onto poly(acrylic acid)-coated glass for a protein-resistant surface.2006

    • Author(s)
      Wazawa, T., Katsura, Y., Nishikawa, S., Iwane, A., Aoyama, S.
    • Journal Title

      Analytical Chemistry 78(8)

      Pages: 2549-2556

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 感度領域調整可能なポリマー導波路型表面プラズモン共鳴センサーの開発2006

    • Author(s)
      松下智彦, 西川武男, 山下英之, 中村恵子, 蓮井亮介, 青山茂
    • Journal Title

      第53回応用物理学関係連合講演会予稿集 No. 3

      Pages: 1068

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Grafting of poly(ethylene glycol) onto poly(acrylic acid)-coated glass for a protein-resistant surface2006

    • Author(s)
      T.Wazawa, Y.Katsura, S.Nishikawa, A.Iwane, S.Aoyama
    • Journal Title

      Analytical Chemistry 78(8)

      Pages: 2549-2556

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Development of an operation range tunable waveguide surface plasmon resonance sensor fabricated by a polymer replication process2006

    • Author(s)
      T.Matsushita, T.Nishikawa, H.Yamashita, M.Nakamura, R.Hasui, S.Aoyama
    • Journal Title

      Extended Abstracts (The 53rd Spring Meeting); The Japan Society of Applied Physics and Related Societies No.3

      Pages: 1068

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] ポリマー複製を用いたシングルモード導波路型表面プラズモン共鳴センサーの開発2005

    • Author(s)
      岸本潤, 西川武男, 松下智彦, 瀬崎浩史, 山下英之, 乗岡茂巳, 和沢鉄一, 青山茂
    • Journal Title

      第52回応用物理学関係連合講演会予稿集 No. 3

      Pages: 1175

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Total Internal Reflection Fluorescence Microscopy in Single Molecule Nanobioscience2005

    • Author(s)
      Wazawa, T., Ueda, M.
    • Journal Title

      Advances in Biochemical Engineering / Biotechnology 95

      Pages: 77-106

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Development of a single-mode waveguide SPR sensor fabricated by a polymer replication method2005

    • Author(s)
      J.Kishimoto, T.Nishikawa, T.Matsushita, H.Sezaki, H.Yamashita, S.Norioka, T.Wazawa, S.Aoyama
    • Journal Title

      Extended Abstracts (The 52nd Spring Meeting) ; The Japan Society of Applied Physics and Related Societies No.3

      Pages: 1175

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Total internal reflection fluorescence microscopy in single molecule nanobioscience2005

    • Author(s)
      T.Wazawa, M.Ueda
    • Journal Title

      Advances in Biochemical Engineering/Biotechnology 95

      Pages: 77-106

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 自己集合した蛋白質を用いた鋳型複製によるナノパターンの作製2004

    • Author(s)
      山下英之, 長岡真吾, 松下智彦, 西川武男, 瀬崎浩史, 乗岡茂巳, 和沢鉄一, 青山茂
    • Journal Title

      生物物理 44

      Pages: S183

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ポリマー複製方式によるシングルモード導波路型表面プラズモン共鳴センサーの開発2004

    • Author(s)
      西川武男, 岸本潤, 瀬崎浩史, 松下智彦, 山下英之, 乗岡茂巳, 和沢鉄一, 青山茂
    • Journal Title

      生物物理 44

      Pages: S266

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Fabrication of nano-pattern using replica molding of self-assembled protein2004

    • Author(s)
      H.Yamashita, S.Nagaoka, T.Matsushita, T.Nishikawa, H.Sezaki, S.Norioka, T.Wazawa, S.Aoyama
    • Journal Title

      Seibutsu Butsuri 44

      Pages: S183

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Development of a single-mode waveguide SPR sensor fabricated through a polymer replication method2004

    • Author(s)
      T.Nishikawa, J.Kishimoto, H.Sezaki, T.Matsushita, H.Yamashita, S.Norioka, T.Wazawa, S.Aoyama
    • Journal Title

      Seibutsu Butsuri 44

      Pages: S266

    • Description
      「研究成果報告書概要(欧文)」より
  • [Patent(Industrial Property Rights)] 表面プラズモンセンサ2006

    • Inventor(s)
      松下智彦, 山下英之, 西川武男, 中村恵子, 蓮井亮介, 青山茂
    • Industrial Property Rights Holder
      オムロン株式会社
    • Industrial Property Number
      特許権・2006-071832
    • Filing Date
      2006-03-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] 表面プラズモンセンサ2006

    • Inventor(s)
      松下智彦, 山下英之, 西川武男, 中枯恵子, 蓮井亮介, 青山茂
    • Industrial Property Rights Holder
      オムロン株式会社
    • Industrial Property Number
      特許権・2006-341138
    • Filing Date
      2006-12-19
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2008-05-27  

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