2004 Fiscal Year Final Research Report Summary
Regulation of lymphocyte development by Notch/RBP-J signaling
| Project/Area Number |
16209018
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
HONJO Tasuku Kyoto University, Graduate School of Medicine, Professor, 医学研究科, 教授 (80090504)
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| Co-Investigator(Kenkyū-buntansha) |
SHINKURA Reiko Kyoto University, Graduate School of Medicine, Research Assistant, 医学研究科, 助手 (50362471)
YABE Daisuke Kyoto University, Graduate School of Medicine, Research Assistant, 医学研究科, 助手 (60378643)
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| Project Period (FY) |
2004
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| Keywords | Notch / RBP-J / Cell fate decision / Cell differentiation / Lymphocyte development / Knockout mouse / Mint |
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| Research Abstract |
To elucidate the functions of Notch/RBP-J signaling in T cell development, we analyzed RBP-J-conditional knockout mice and reported that Notch/RBP-J signaling negatively regulates γ δ T cell generation, on the other hand, it promotes a β T cell maturation in thymi. We also demonstrated that Notch/RBP-J signaling enhances Th2 response in the periphery. Moreover, by analyzing Mint, an endogenous inhibitor of Notch/RBP-J signaling, knockout mice, we demonstrated that Notch/RBP-J signaling negatively regulates early thymocyte differentiation and that Mint suppresses the Notch/RBP-J signaling in thymic T cell development and in splenic B cell differentiation. We also reported that Mint regulates neuronal cell survival in postnatal brain.
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