2006 Fiscal Year Final Research Report Summary
New development in molecular genetic and molecular pharmacological studies on intractable intraocular inflammation.
| Project/Area Number |
16209051
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
OHNO Shigeaki Hokkaido Univ., Grad. School of Med., Prof., 大学院医学研究科, 教授 (50002382)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Kazuhiko Hokkaido Univ., Hokkaido Univ. Hospital, Lec., 講師 (90281807)
NAMBA Kenichi Hokkaido Univ., Grad. School of Med., Inst., 大学院医学研究科, 助手 (70333599)
MIZUKI Nobuhisa Yokohama city Univ., Grad. School of Med., Prof., 医学部, 教授 (90336579)
INOKO Hidetoshi Toukai Univ., Grad. School of Med., Prof., 医学部, 教授 (10101932)
ONOE Kazunori Hokkaido Univ., Institute for Genetic Med., Prof., 遺伝子病制御研究所, 教授 (40002117)
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| Project Period (FY) |
2004 – 2006
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| Keywords | intractable intraocular inflammation / uveitis / microsatellite / pooled DNA / oxidative stress |
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| Research Abstract |
Association analysis was carried out for the Behcet's disease and the Vogt-Koyanagi-Harada (VKH) disease. In the 23,465 microsatellite markers on whole genome, 147 markers (0.63%) was picked up as susceptible genes areas of the Behcet's disease. In the VKH disease, which is the popular uveitis in Japan, is known about the strong association with HLA-DR area. However, other association area is detected on the long arm of chromosome 6. We are now analyzing the functions of this area.
In refractory intraocular inflammation groups, nitric oxide levels in the aqueous humor and blood were significantly higher than that in the control group. On the other hand, Treatment with antioxidative compounds significantly suppressed ocular inflammation. The results indicate that these compounds show a significant anti-inflammatory effect. For instance, Treatment with the crude extract by blue honeysuckle, the flora of north countries, has a strong anti-oxidative effect, significantly suppressed inflammation in refractory intraocular inflammation model in a dose-dependent manner.
Immunomodulatory granulocytapheresis therapy was revealed to be significantly effective to reduce frequency of light threatening ocular inflammatory attacks in Behcet's disease. And it was also indicated that this therapy was effective in the patient especially with less than 5 years duration of the disease from onset.
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[Journal Article] Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo.2006
Author(s)
Harada C, Nakamura K, Namekata K, Okumura A, Mitamura Y, lizuka Y, Kashiwagi K, Yoshida K, Ohno S, Matsuzawa A, Tanaka K, Ichijo H, Harada T
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Journal Title
Am J Pathol 168
Pages: 261-269
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma.2005
Author(s)
Kase S, Saito W, Yoshida K, Namba K, Osaki M, Ohgami K, Shiratori K, Kitaichi N, Adachi H, Ito H, Ohno S
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Journal Title
Pathol Int 55
Pages: 569-573
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Disappearance of p27(KIP1) and increase in proliferation of the lens cells after extraction of most of the fiber cells of the lens.2005
Author(s)
Kase S, Ikeda H, Harada T, Harada C, Imaki J, Ohgami K, Shiratori K, Nakayama K I., Nakayama K, Ohno S, Yoshida K:
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Journal Title
Cur Eye Res 30
Pages: 437-442
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Anti-inflammatory effects of aroni extract on rat endotoxin-induced uveitis.2005
Author(s)
Ohgami K, Ilieva B.I, Shiratori K, Koyama Y, Xue-Hai Jin, Yoshida K, Kase S, Kitaich N, Suzuki Y, Tanaka T, Ohno S
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Journal Title
Invest Ophthalmol Vis Sci 46
Pages: 275-281
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Efficacy, safety, and pharmacokinetics of multiple administration of infliximab in Behcet' disease with refractory uveoretinitis.2004
Author(s)
Ohno S, Nakamura S, Hori S, Shimakawa M, Kawashima H, Mochizuki M, Sugita S, Uenc S, Yoshizaki K, Inaba G
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Journal Title
J Rheumatol 31
Pages: 1362-1368
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Involvement of p27KIP1 in the proliferation of the developing corneal endothelium.2004
Author(s)
Yoshida K, Kase S, Nakayama K, Nagahama H, Harada T, Ikeda H, Harada C, Imaki J, Ohgami K, Shiratori K, Iliyana B I, Ohno S, Nishi S, Nakayama K I
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Journal Title
Invest Ophthalmol Vis Sci 45
Pages: 2163-2167
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Distribution of p27(KIP1), cyclin D1, and proliferating cell nuclear antigen after retinal detachment.2004
Author(s)
Yoshida K, Kase S, Nakayama K, Nagahama H, Harada T, Ikeda H, Harada C, Imaki J, Ohgami K, Shiratori K, Ohno S, Nakayama KI
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Journal Title
Graefe' s Arch Clin Exp Ophthalmol 242
Pages: 437-441
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Involvement of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary body.2004
Author(s)
Yoshida K, Nakayama K, Kase S, Nagahama H, Harada T, Ikeda H, Harada C, Imaki J, Ohgami K, Shiratori K, Ohno S, Nishi S, Nakayama KI
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Journal Title
Anat Embryol (BerlMar 9)
Pages: 145-150
Description
「研究成果報告書概要(欧文)」より
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