2006 Fiscal Year Final Research Report Summary
The development of taste-bud-inspired chemical sensors and their use in elucidating the taste information processing by cell-networks formed by taste bud cells.
| Project/Area Number |
16300094
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Kyushu Institute of Technology |
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Principal Investigator |
YOSHII Kiyonori Kyushu Institute of Technology, Graduate School of Life Science and Systems Engineering, Professor, 大学院生命体工学研究科, 教授 (30125364)
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| Co-Investigator(Kenkyū-buntansha) |
MIKI Tsutomu Kyushu Institute of Technology, Graduate School of Life Science and Systems Engineering, Associate Professor, 大学院生命体工学研究科, 助教授 (20231607)
TATENO Katsumi Kyushu Institute of Technology, Graduate School of Life Science and Systems Engineering, Associate Professor, 大学院生命体工学研究科, 助教授 (00346868)
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| Project Period (FY) |
2004 – 2006
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| Keywords | electrophysiology / computer science / integrated circuit engineering / mouse / taste receptors / intracellular Ca^<2+> / NIS / integration-and-fire model |
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| Research Abstract |
Taste receptors of animals consist of taste cells with varied responsiveness to taste substances. Also our recent findings showed that taste cells form cell-networks within taste receptors, suggesting the crosstalk between taste cells. Neither irregular responsiveness nor crosstalk has been avoided in engineering. However, animals utilize these properties to have taste receptors perform excellently. In this study, we proposed chemical sensors inspired by taste receptors with multiple perspectives including electrophysiology, computer science, and integrated circuit engineering. We showed that non-compensated sensors assembled into networks reproduced animal taste responses in the discrimination of taste qualities and intensities. These results suggest that animal taste receptors supply ideas to utilize irregular parts that have been rejected and crosstalk has been neglected as noises.
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