• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2007 Fiscal Year Final Research Report Summary

Rearch of neuronal activity underlying formation of various long-term memory.

Research Project

Project/Area Number 16330140
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental psychology
Research InstitutionKyoto University

Principal Investigator

SAKURAI Yoshio  Kyoto University, Graduate School of Letters, Professor (60153962)

Project Period (FY) 2004 – 2007
Keywordslong-term memory / neuronal circuit / neuronal activity / synapse / ICA / hippocampus / frontal cortex / rats
Research Abstract

(1) For rats, we developed several behavioral tasks to see processes of formation of various long-term memory. One example of the task was conditional discrimination, in which the rats were required to associate conditional tones(high or low) and response holes (right or left). The rats acquired the task in a few days, during which we recorded multi-neuronal activity from their hippocampal formation and neocortical frontals cortex.
(2) We developed new techniques, i.e., electrode, head-amp, microdrive, and spike-sorting system, to record and analyze multi-neuronal activity in the behaving animals. These techniques could be applied to brain-machine interface (BMI).
(3) The most remarkable one of the newly developed techniques is a new method to detect precise sub-millisecond interactions among neurons in freely behaving animals. The technique uses a combination of independent component analysis (ICA) and newly developed multi-electrodes. That is an in vivo electrophysiological technique capable of real-time and automatic sorting of extracellular activity of closely neighboring single-neurons to detect their sub-millisecond interactions even via gap-junctions (electrical synapses). The technique also could detect dendritic backpropagation of action potentials and electrically coupled cells via gap junctions.
(4) We succeeded to separate extracellular signals from the soma and those from the dendrite of a single CA1 neuron by the unique method. Then we examined spatial information coded by spikes from the soma and dendrite of CA1 neurons when the rats were moving in an open environment. The results indicate that the somatic spikes had single place fields and showed higher spatial specificity than the dendritic spikes. Therefore we conclude that a hippocampal pyramidal neuron has the ability to transform redundant spatial information received from upstream neurons via the dendrites into more place-specific information along the dendrosomatic axis.

  • Research Products

    (36 results)

All 2008 2007 2006 2005 2004 Other

All Journal Article (16 results) (of which Peer Reviewed: 8 results) Presentation (17 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Coding of spatial information by soma and dendrite of pyramidal cells in the hippocampal CA1 of behaving rats.2007

    • Author(s)
      Takahashi, S., and Sakurai, Y.
    • Journal Title

      European Journal of Neuroscience 26

      Pages: 2033-2045

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Analysis of multineuron activity using the kernel method.2007

    • Author(s)
      Nomura, M., Sakurai, Y. and Aoyagi, T.
    • Journal Title

      Journal of Robotics and Mechatronics 19

      Pages: 364-368

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Coding of spatial information by soma and dendrite of pyramidal cells in the hippocampal CA1 of behaving rats2007

    • Author(s)
      Takahashi, S., Sakurai, Y
    • Journal Title

      European Journal of Neuroscience 26

      Pages: 2033-2045

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Analysis of multineuron activity using the kernel method2007

    • Author(s)
      Nomura, M., Sakurai, Y., Aoyagi, T
    • Journal Title

      Journal of Robotics and Mechatronics 19

      Pages: 364-368

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dynamic synchrony of fring in the monkey prefrontal cortex during working memory tasks2006

    • Author(s)
      Sakurai, Y., and Takahashi, S.
    • Journal Title

      Journal of Neuroscience 26

      Pages: 10141-10153

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Prediction of arm trajectory from a small number of neuron activities in the primary motor cortex.2006

    • Author(s)
      Koike, Y., Hirose, H., Sakurai, Y. and Iijima, T.
    • Journal Title

      Neuroscience Research 56

      Pages: 146-153

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Dynamic synchrony of firing in the monkey prefrontal cortex during working memory tasks2006

    • Author(s)
      Sakurai, Y., Takahashi, S
    • Journal Title

      Journal of Neuroscience 26

      Pages: 10141-10153

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Prediction of arm trajectory from a small number of neuron activities in the primary motor cortex2006

    • Author(s)
      Koike, Y., Hirose, H., Sakurai, Y., lijima, T
    • Journal Title

      Neuroscience Research 56

      Pages: 146-153

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 7-12 Hz cortical oscillations: Behavioral context and dynamics of prefrontal neuronal ensembles.2005

    • Author(s)
      Sakata, S., Yamamori, T., and Sakurai, Y.
    • Journal Title

      Neuroscience 134

      Pages: 1099-1111

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Real-time and automatic sorting of multi-neuronal activity for sub-millisecond interactions in vivo.2005

    • Author(s)
      Takahashi, S. and Sakurai, Y.
    • Journal Title

      Neuroscience 134

      Pages: 1301-315

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] 7-12 Hz cortical oscillations : Behavioral context and dynamics of prefrontal neuronal ensembles2005

    • Author(s)
      Sakata, S., Yamamori, T., Sakurai, Y
    • Journal Title

      Neuroscience 134

      Pages: 1099-1111

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Real-time and automatic sorting of multi-neuronal activity for sub-millisecond interactions in vivo2005

    • Author(s)
      Takahashi, S., Sakurai, Y
    • Journal Title

      Neuroscience 134

      Pages: 301-315

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Stimulus duration in working memory is represented by neuronal activity in the monkey prefrontal cortex.2004

    • Author(s)
      Sakurai, Y., Takahashi, S., and Inoue, M.
    • Journal Title

      European Journal of Neuroscience 20

      Pages: 1069-1080

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Behavioral studies of auditory-visual spatial recognition and integration in rats.2004

    • Author(s)
      Sakata, S., Yamamori, T. and Sakurai, Y.
    • Journal Title

      Experimental Brain Research 159

      Pages: 409-417

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Stimulus duration in working memory is represented by neuronal activity in the monkey prefrontal cortex2004

    • Author(s)
      Sakurai, Y., Takahashi, S., Inoue, M
    • Journal Title

      European Journal of Neuroscience 20

      Pages: 1069-1080

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Behavioral studies of auditory-visual spatial recognition and integration in rats2004

    • Author(s)
      Sakata, S., Yamamori, T., Sakurai, Y
    • Journal Title

      Experimental Brain Research 159

      Pages: 409-417

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Spatial information coded by the soma and dendrite of pyramidal cells in the hippocampus of behaving rats2007

    • Author(s)
      Takahashi, S. and Sakurai, Y.
    • Organizer
      37th Society for Neuroscience Annual Meeting
    • Place of Presentation
      サンディエゴ(米国)
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Spatial information coded by the soma and dendrite of pyramidal cells in the hippocampus of behaving rats2007

    • Author(s)
      Takahashi, S., Sakurai, Y
    • Organizer
      37th Society for Neuroscience Annual Meeting
    • Place of Presentation
      Sandiego (USA)
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Sub-millisecond synchronization among pyramidal neurons in hippocampal CA1 of rats during delayed non-matching to sample task.2006

    • Author(s)
      Takahashi, S., and Sakurai, Y.
    • Organizer
      36th Society for Neuroscience Annual Meeting
    • Place of Presentation
      ニューオリンズ(米国)
    • Year and Date
      2006-10-17
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] A distinct area of rat visual cortex mediates behavioral enhancement by audiovisual integration2006

    • Author(s)
      Hirokawa, J., M. Bosch, Sakata, S., Sakurai, Y. and Yamatori, T.
    • Organizer
      36th Society for Neuroscience Annual Meeting
    • Place of Presentation
      ニューオリンズ(米国)
    • Year and Date
      2006-10-17
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Sub-millisecond synchronization among pyramidal neurons in hippocampal CAI of rats during delayed non-matching to sample task2006

    • Author(s)
      Takahashi, S., Sakurai, Y
    • Organizer
      36th Society for Neuroscience Annual Meeting
    • Place of Presentation
      New Orleans (USA)
    • Year and Date
      2006-10-17
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] A distinct area of rat visual cortex mediates behavioral enhancement by audiovisual integration2006

    • Author(s)
      Hirokawa, J, M., Bosch, Sakata, S., Sakurai, Y., Yamatori, T
    • Organizer
      36th Society for Neuroscience Annual Meeting
    • Place of Presentation
      New Orleans (USA)
    • Year and Date
      2006-10-17
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 海馬マルチニューロンによるBMIから情報表現と可塑性を見る2006

    • Author(s)
      櫻井芳雄・高橋晋
    • Organizer
      第28回日本神経科学学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2006-07-28
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 細胞集成体の実験的検証とブレイン-マシン・インタフェース2006

    • Author(s)
      櫻井芳雄・高橋晋
    • Organizer
      第29回日本神経科学学会大会
    • Place of Presentation
      京都
    • Year and Date
      2006-07-21
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Brain plasticity revealed with brain-machine interfaces2006

    • Author(s)
      Sakurai, Y.
    • Organizer
      1st International Conference on Advanced Medical Engineering and Informatics
    • Place of Presentation
      大阪
    • Year and Date
      2006-06-04
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Brain plasticity revealed with brain-machine interfaces2006

    • Author(s)
      Sakurai, Y
    • Organizer
      1st International Conference on Advanced Medical Engineering and Informatics
    • Place of Presentation
      Osaka
    • Year and Date
      2006-06-04
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Brain-machine interface to detect dynamics of neuronal assemblies in the working brain2005

    • Author(s)
      Sakurai, Y.
    • Organizer
      1st International Conference on Complex Biomedical Engineering(CME2005)
    • Place of Presentation
      高松
    • Year and Date
      2005-05-17
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Brain-machine interface to detect dynamics of neuronal assemblies in the working brain2005

    • Author(s)
      Sakurai, Y
    • Organizer
      1st International Conference on Complex Biomedical Engineering
    • Place of Presentation
      Takamatsu
    • Year and Date
      2005-05-17
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Brain-sate-dependent synchronized oscillation in prefrontal cortex.2004

    • Author(s)
      Sakata, S., Yamamori, T., and Sakurai, Y.
    • Organizer
      34th Society for Neuroscience Annual Meeting.
    • Place of Presentation
      マイアミ(米国)
    • Year and Date
      2004-10-26
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Brain-sate-dependent synchronized oscillation in prefrontal cortex2004

    • Author(s)
      Sakata, S., Yamamori, T., Sakurai, Y
    • Organizer
      34th Society for Neuroscience Annual Meeting
    • Place of Presentation
      Miami (USA)
    • Year and Date
      2004-10-26
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Real-time spike sorting system for sub-millisecond neuronal interactions in vivo.2004

    • Author(s)
      Takahashi, S., and Sakurai, Y.
    • Organizer
      34th Society for Neuroscience Annual Meeting.
    • Place of Presentation
      マイアミ(米国)
    • Year and Date
      2004-10-25
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Real-time spike sorting system for sub-millisecond neuronal interactions in vivo2004

    • Author(s)
      Takahashi, S., and Sakurai, Y
    • Organizer
      34th Society for Neuroscience Annual Meeting
    • Place of Presentation
      Miami (USA)
    • Year and Date
      2004-10-25
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 刺激提示時間のワーキングメモリーにおけるサル前頭連合野ニューロンの相関活動2004

    • Author(s)
      櫻井芳雄・高橋晋
    • Organizer
      第27回日本神経科学学会・第47回日本神経化学学会合同大会,
    • Place of Presentation
      大阪
    • Year and Date
      2004-09-23
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 脳の情報表現を見る2008

    • Author(s)
      櫻井芳雄
    • Total Pages
      191
    • Publisher
      京都大学学術出版会
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] ブレイン-マシン・インタフェース最前線-脳と機械を結ぶ革新技術2007

    • Author(s)
      櫻井芳雄
    • Total Pages
      204
    • Publisher
      工業調査会
    • Description
      「研究成果報告書概要(和文)」より
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.bun.kyoto-u.ac.jp/~ysakurai/

URL: 

Published: 2010-02-04  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi