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2006 Fiscal Year Final Research Report Summary

Organic Syntheses using Highly Reactive and Functional Organometallics

Research Project

Project/Area Number 16350050
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Synthetic chemistry
Research InstitutionUniversity of Tsukuba

Principal Investigator

HOSOMI Akira  University of Tsukuba, Professor Emeritus, 名誉教授 (00004440)

Co-Investigator(Kenkyū-buntansha) HOJO Makoto  University of Tsukuba, Graduate School of Pure and Applied Sciences, Associate Professor, 大学院数理物質科学研究科, 助教授 (50229150)
MIURA Katsukiyo  University of Tsukuba, Graduate School of Pure and Applied Sciences, Associate Professor, 大学院数理物質科学研究科, 助教授 (20251035)
Project Period (FY) 2004 – 2006
KeywordsVinylsilanes / Catalytic Process / Organic Syntheses / Mixed Lewis acid / Active Species / Organosilicon Chemistry / Organometallic Chemistry / Manganate Reagents
Research Abstract

1. Preparation of Dimethylsilyl-Protected Nucleophiles and Their Use for Organic Synthesis :
Most of organosilicon reagents have a trimethylsilyl (TMS) group or a more bulky triorganosilyl group. Synthetic utility of silicon reagents bearing a less bulky silyl group has remained unexplored. We have found that dimethylsilyl (DMS)-protected nucleophiles are more reactive than TMS-protected nucleophiles. For example, in the presence of CaCl_2, ketone DMS enolates added smoothly to aldehydes at 30 ℃ in DMF to give aldols in high yield. In the reaction of DMS enolates, CaCl_2 would serve as Lewis base to activate the enolates by nucleophilic attack of the silicon by the chloride ion. DMS enolates are useful for the Mannich-type reaction of N-tosylimines and the Michael reaction of α-enones. Similarly, α-DMS-esters are more reactive than the corresponding TMS-based reagents. In the presence of metal chlorides (LiCl, MgCl_2, etc.), aldehydes and ketones underwent efficient aldol reactions of a … More -DMS-esters.
We have developed the tandem aldol-reduction reaction of aldehydes with DMS enolates, which directly forms 1,3-diols stereoselectively. In this case, DMS enolates play two roles of carbon nucleophile and reductant. We have also demonstrated that DMS ethers and amines are valuable for reductive etherification and amination of carbonyls in the presence of a Lewis acid.
2. Reduction and Carbon-Carbon Bond Formation under Catalysis by Indium Salts :
We have found that PhSiH_3 reacts with haloalkanes in the presence of In(OAc)_3 to form the dehalogenated alkanes. This reduction would involve a radical chain mediated by indium hydride species. The PhSiH_3-In(OAc)_3 system is applicable to intermolecular radical addition of haloalkanes to electron-deficient alkenes. Additionally, it is valuable also for reductive aldol reaction of a-enones with aldehydes.
We have succeeded in indium salt-promoted intramolecular addition of allylstannanes, allylsilanes, and silyl enolates to unactivated alkynes. The addition of allylstannanes proceeds probably by Sn-In transmetalation and subsequent allylindation, while the addition of allylsilanes and silyl enolates would involve electrophilic activation of the triple bond with the indium salts followed by nucleophilic addition of these silyl-protected nucleophiles. In the reaction of silyl enolates, the resultant vinylindium species can be used for further reaction with heteroatom and carbon electrophiles. Less

  • Research Products

    (30 results)

All 2007 2006 2005 2004

All Journal Article (29 results) Book (1 results)

  • [Journal Article] Homolytic Hydrogermylation of Alkenes with Dibutylchlorogermane2007

    • Author(s)
      A.Hosomi
    • Journal Title

      J. Organometal. Chem. 692

      Pages: 514-519

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Indium-Catalyzed Radical Reductions of Organic Halides with Hydrosilanes2007

    • Author(s)
      A.Hosomi
    • Journal Title

      J. Org. Chem. 72(3)

      Pages: 787-792

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Homolytic Hydrogermylation of Alkenes with Dibutylchlorogermane2007

    • Author(s)
      Katsukiyo Miura, Kazunori Ootsuka, Akira Hosomi
    • Journal Title

      J.Organometal.Chem. 692

      Pages: 514-519

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Indium-Catalyzed Radical Reductions of Organic Halides with Hydrosilanes2007

    • Author(s)
      Katsukiyo Miura, MIturu Tomita, Yusuke Yamada, Akira Hosomi
    • Journal Title

      J.Org.Chem. 72 (3)

      Pages: 787-792

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Indium(III) Salt-Promoted Intramolecular Addition of Allylsilanes to Alkynes2006

    • Author(s)
      A.Hosomi
    • Journal Title

      Synlett (12)

      Pages: 1883-1886

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Indium (III) Salt-Promoted Intramolecular Addition of Allylsilanes to Alkynes2006

    • Author(s)
      Katsukiyo Miura, Naoki Fujisawa, Sayaka Toyohara, Akira Hosomi
    • Journal Title

      Synlett (12)

      Pages: 1883-1886

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] "Silicon" in Comprehensive Organometallic Chemistry III2006

    • Author(s)
      A-Hosomi
    • Journal Title

      Elsevier 42

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Highly Regio- and Stereoselective Hydrostannylation of Propargyl Alcohols and Ethers Using Dibutylchlorostannane and Lithium Chloride2005

    • Author(s)
      A.Hosomi
    • Journal Title

      Synlett. (3)

      Pages: 406-410

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Highly Regio- and Stereoselective Hydrostannylation of Alkynols with A New Lewis Acidic Hydrostannane2005

    • Author(s)
      A.Hosomi
    • Journal Title

      Org. Lett. 7(3)

      Pages: 503-505

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Highly Diastereoselective Hydrostannylation of Allyl and Homoallyl Alcohols with Dibutyl(trifluoromethanesulfoxy)-stannane2005

    • Author(s)
      A.Hosomi
    • Journal Title

      J. Am. Chem. Soc. 127(26)

      Pages: 9366-9367

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Metal Chloride-Promoted Aldol Reaction of α-Dimethyl-silylesters with Aldehydes and Ketones, and α-Enones2005

    • Author(s)
      A.Hosomi
    • Journal Title

      Synlett (12)

      Pages: 1917-1921

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Platinum(II) Salt-Catalyzed Annulation of Hydroxyalkyl-Substituted Vinylsilanes with Aldehydes2005

    • Author(s)
      A.Hosomi
    • Journal Title

      Synlett (20)

      Pages: 3148-3150

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Synthetic Radical Reactions Using Dibutylchlorogermane and Dibutylethoxygermane as Radical Mediators2005

    • Author(s)
      A.Hosomi
    • Journal Title

      Synlett (20)

      Pages: 3151-3153

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Highly Regio-and Stereoselective Hydrostannylation of Propargyl Alcohols and Ethers Using Dibutylchlorostannane and Lithium Chloride2005

    • Author(s)
      Katsukiyo Miura, Di Wang, Akira Hosomi
    • Journal Title

      Synlett (3)

      Pages: 406-410

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Highly Regio-and Stereoselective Hydrostannylation of Alkynols with A New Lewis Acidic Hydrostannane2005

    • Author(s)
      Katsukiyo Miura, Di Wang, Yukihiro Matsumoto, Akira Hosomi
    • Journal Title

      Org. Lett. 7 (3)

      Pages: 503-505

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Highly Diastereoselective Hydrostannylation of Allyl and Homoallyl Alcohols with Dibutyl (trifluoromethanesulfoxy) stannane2005

    • Author(s)
      Katsukiyo Miura, Di Wang, Akira Hosomi
    • Journal Title

      J.Am.Chem.Soc 127 (26)

      Pages: 9366-9367

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Metal Chloride-Promoted Aldol Reaction of α-Dimethylsilylesters with Aldehydes and Ketones, and α-Enones2005

    • Author(s)
      Katsukiyo Miura, Takahiro Nakagawa, Akira Hosomi
    • Journal Title

      Synlett (12)

      Pages: 1917-1921

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Platinum (II) Salt-Catalyzed Annulation of Hydroxyalkyl- Substituted Vinylsilanes with Aldehydes2005

    • Author(s)
      Katsukiyo Miura, Ryou Itaya, Makoto Horiike, Hiroyuki Izumi, Akira Hosomi
    • Journal Title

      Synlett (20)

      Pages: 3148-3150

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Synthetic Radical Reactions Using Dibutylchlorogermane and Dibutylethoxygermane as Radical Mediators2005

    • Author(s)
      Katsukiyo Miura, Kazunori Ootsuka, Akira Hosomi
    • Journal Title

      Synlett (20)

      Pages: 3151-3153

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Development of New Reagents Containing Silicon and Related Metals and Application to the Practical Organic Synthesis2004

    • Author(s)
      A.Hosomi
    • Journal Title

      Bull. Chem. Soc. Japan 77(5)

      Pages: 835-851

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cascade Carbonylation Methods Leading to β-Diketones and β-Functionalized δ-Diketones2004

    • Author(s)
      A.Hosomi
    • Journal Title

      Angew. Chem. Int. Ed. 43(4)

      Pages: 1023-1029

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Indium(III) Chloride-Promoted Intramolecular Addition of Allylstannanes to Alkynes2004

    • Author(s)
      A.Hosomi
    • Journal Title

      J. Org. Chem. 69(7)

      Pages: 2427-2430

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Alkylation of Acetals Using Manganate-BF_3・OEt_2 Mixed Reagent2004

    • Author(s)
      A.Hosomi
    • Journal Title

      Tetrahedron Lett. 45(23)

      Pages: 4499-4501

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Indium(III) Acetate-Catalyzed 1,4-Reduction and Reductive Aldol Reactions of a-Enones with Phenylsilane2004

    • Author(s)
      A.Hosomi
    • Journal Title

      Synlett (11)

      Pages: 1985-1989

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Development of New Reagents Containing Silicon and Related Metals and Application to the Practical Organic Synthesis2004

    • Author(s)
      Katsukiyo Miura, Akira Hosomi
    • Journal Title

      Bull.Chem.Soc.Japan 77 (5)

      Pages: 835-851

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cascade Carbonylation Methods Leading to β-Diketones and β-Functionalized δ-Diketones2004

    • Author(s)
      Katsukiyo Miura, Mami Tojino, Naoki Fujisawa, Akira Hosomi, Ilhyong Ryu
    • Journal Title

      Angew.Chem.Int.Ed. 43 (4)

      Pages: 1023-1029

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Indium (III) Chloride-Promoted Intramolecular Addition of Allylstannanes to Alkynes2004

    • Author(s)
      Katsukiyo Miura, Naoki Fujisawa, Akira Hosomi
    • Journal Title

      J.Org.Chem. 69 (7)

      Pages: 2427-2430

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Alkylation of Acetals Using Manganate-BF3・OEt2 Mixed Reagent2004

    • Author(s)
      Makoto Hojo, Nobuo Ushioda, Akira Hosomi
    • Journal Title

      Tetrahedron Lett. 45 (23)

      Pages: 4499-4501

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Indium (III) Acetate-Catalyzed 1,4-Reduction and Reductive Aldol Reactions of a-Enones with Phenylsilane2004

    • Author(s)
      Katsukiyo Miura, Yusuke Yamada, Mitsuru Tomita, Akira Hosomi
    • Journal Title

      Synlett (11)

      Pages: 1985-1989

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Siilicon in Comprehensive Organometallic Chemistry III2006

    • Author(s)
      A.Hosomi
    • Total Pages
      42
    • Publisher
      Elsevier
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2008-05-27  

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