2006 Fiscal Year Final Research Report Summary
Development of Highly Efficient Synthetic Reactions by Controlling Electron-Transfer Processes with a Combination of Different Metals
| Project/Area Number |
16350057
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | OKYAMA UNIVERSITY |
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Principal Investigator |
TAKAI Kazuhiko Okayama University, Graduate School of Natural Science and Technology, Division of Chemistry and Biochemistry, Professor, 大学院自然科学研究科, 教授 (00144329)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIKI Toshiyuki Okayama University, Graduate School of Natural Science and Technology, Division of Chemistry and Biochemistry, Lecturer, 大学院自然科学研究科, 講師 (80311794)
KUNINOBU Yoichiro Okayama University, Graduate School of Natural Science and Technology, Division of Chemistry and Biochemistry, Assistant Professor, 大学院自然科学研究科, 助手 (40372685)
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| Project Period (FY) |
2004 – 2006
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| Keywords | Electron Transfer / Low-valent Metal / Zinc / Chromium / Nickel / Tantalum-Alkyne Complex / Rhenium Catalyst / C-H Bond Activation |
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| Research Abstract |
The following stereoselective reactions are developed by controlling electron-transfer processes. (1) Cross-Coupling Reactions of Alkynes and Aldehydes Leading to Allylic Alcohols by a Combination of Chromium(II), a Catalytic Amount of Nickel(II), and Water. (2) Preparation of Cyclopropylsilanes from Terminal Alkenes with Organochromium Reagents. (3) Transformation of Aldehydes into (E)-1-Alkenylsilanes and (E)-1-Alkenylboronic Esters with a Catalytic Amount of a Chromium Salt and Zinc (or Manganese). (4) Mechanistic Study of Ligand Exchange Reactions of η^-TaCl_3(Me_3SiC=CSiMe_3)(dme) with Internal Alkynes. (5) Cyclotrimerization of Terminal Alkynes with a Catalytic Amount of η^2-TaCl_3(Me_3SiC=CSiMe_3)(dme).
In addition, we developed novel organic reactions based on carbon-hydrogen bond activation with rhenium catalysts : (6) Rhenium-Catalyzed Formation of Indene Frameworks via C-H Bond Activation from Aromatic Aldimines and Acetylenes ; (7) Insertion of Polar Unsaturated Molecules into Carbon-Rhenium Bonds Generated by C-H Bond Activation: Synthesis of Isobenzofuran and Phthalimidine Derivatives ; (8) Rhenium-and Aniline-Catalyzed One-Pot Annulation of Aromatic Ketones and α,β-Unsaturated Esters Initiated by C-H Bond Activation.
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