2006 Fiscal Year Final Research Report Summary
Precision Synthesis and Molecular Recognition Ability of Aliphatic Polyether-type Nano-Spherical Carbohydrate Polymers
| Project/Area Number |
16350064
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
AOI Keigo Nagoya University, Graduate School of Bioagricultural Sciences, Professor (30222467)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Masahiko Chubu University, College of Bioscience and Biotechnology, Professor (20023103)
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| Project Period (FY) |
2004 – 2006
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| Keywords | dendrimer / sugar ball / carbohydrate polymer / molecular recognition / nano-materials / biomedical materials / drug delivery system / gene delivery system |
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| Research Abstract |
The present study is concerned with design, synthesis and molecular recognition of a new type of dendrimer-based polymeric nano-materials having sugar-derivatives as a cell recognition marker. Dendrimers are important polymers having controlled chemical structure with a core, branches and surface sectors, which are designed and synthesized independently. We have already presented drug and gene delivery systems based on sugar balls, which have sugar moieties at the surface of the dendrimer backbone. In the present study, aliphatic polyethersareappliedtothesugar-substituteddendrimersin order to increase biocompatibility and decrease toxicity. The inside poly(ethylene glycol) dendrimer was synthesized by stepwise convergent method. The structure of the polyether dendrimers was well characterized using NMR, IR, UV, MALDI-TOF MS, and SEC analyses. The intersugar distance and molecular recognition ability was affected by changing sugar residues such as N-acetyl-D-glucosamine, D-galactose and lactose derivatives. Relationship between the chemical structure and molecular recognition ability was discussed in relation to biomaterials design using globular dendrimer skeleton.
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