DDS of Immunostimulate ODN by use of DNA/Polysaccharide Complexes

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 16350068
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Polymer chemistry
• Research Institution: The University of Kitakyushu
• Principal Investigator: SAKURAI Kazuo The University of Kitakyushu, Faculty of Environmental Engineering, Professor (70343431)
• Project Period (FY): 2004 – 2007
• Keywords: Nanogel / chemical crosslinking / Nanosize / Antigen presenting cell / Overexpression of MIF / RAW and HEK / Anti-dectin-1 antibody

Research Abstract

A b-(1 → 3) -D-glucan schizophyllan (SPG) forms a stoichiometric complex with some polynucleotides. This communication describes our attempt to apply the SPG complex to deliver CpG DNA to endosomes to enhance cytokine secretion. To increase cellular uptake, we introduced spermine, arginine-glycine-aspartic acid tripeptide, octaarginine, or cholesterol to the SPG side chain. The chemically modified SPG showed essentially no cytotoxicity. When CpG DNA complex made therefrom was exposed to macrophages, dramatic enhancement in the cytokine secretion was observed. It increased 5-10 times from the naked dose and 100 times from the background. This performance promises that SPG can be an excellent carrier for CpG DNA.

Research Products

• [Journal Article] Complex Made from N,N-Bis(carboxymethyl)Glutamate Tetraso dium Salt and Sodium Oleate that Forms a Highly Ordered Lamella in Gel Phase (2007)
  • Author(s): Jeong, Y., Uezu.K., Sakurai, S., Masunaga, H., Inoue, K., Sasaki, S., Shimada, N., Takeda, Y, Kaneko, K.and Sakurai, K.
  • Journal Title: Bull.Chem.Soc.Jpn 80(2) Pages: 410-417
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Ternary Complex Consisting of DNA,Polycation,and a Natural Polysaccharide of Schizophyllan to Induce Cellular Uptake by Antigen Presenting Cells (2007)
  • Author(s): Yoichi Takeda, Naohiko Shimada, Kenji Kaneko, Seiji Shinkai, and Kazuo Sakurai.
  • Journal Title: Biomacromolecules 2(3) Pages: 641-650
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] DNA Conformational Switching by Use of an Intercalator and Its Receptor (2007)
  • Author(s): Tomoki Nishimura, Yoichi Takeda, Naohiko Shimada, and Kazuo Sakurai1
  • Journal Title: Chemistry Letters 36(3) Pages: 388-389
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Instantaneous Inclusion of a Polynucleotide and Hydrophobic Guest Molecules into a Helical Core of Cationic -1,3-Glucan Polysaccharide (2007)
  • Author(s): Ikeda, M.; Hasegawa, T.; Numata, M.; Sugika wa, K.; Sakurai, K.; Fujiki, M.; Shinkai, S.
  • Journal Title: J.Am.Chem.Soc 129(13) Pages: 3979-3988
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Salt-Concentration Dependence of the Structure and Form Factors for the Wormlike-Micelle Made from LES/AMPB Dual-Surfactant in Aqueous Solution (2007)
  • Author(s): Kenichi Eguchi, Isamu Kaneda, Yoshiko Hiwatari, Hiroyasu Masunagac and Kazuo Sakurai.
  • Journal Title: J.Applied Crystallography 40 Pages: 264-268
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A Polysaccharide Carrier to Effectively Deliver Native Phosp hodiester CpG DNA to APCs (2007)
  • Author(s): Naohiko Shimada, Cevayir Coban, Yoichi Takeda, Masami Mizu, Jusaku Minari, Takahisa Anada, Yuichi Torii, Seiii Shinkai, Shizuo Akira, Ken J.Ishii, Kazuo Sakurai
  • Journal Title: Bioconjugate Chem Pages: 1136-1140
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Delivery of Antisense Oligonucleotides to Nucle ar Telomere RNA by Use of a Complex betwe en Polysaccharide and Polynucleotide (2007)
  • Author(s): Jusaku Minari, Takanori Kubo, Hideki Ohba, Naohiko Shimada, Yoich Takeda, Ryouji Karinaga, Takahisa Anada, Kazuya Koumoto, Takeshi Kawazu, Takeshi Nagasaki, Seiji Shinkai, and Kazuo Sakurai.
  • Journal Title: Bull.Chem.Soc.Jpn 80(6) Pages: 1091-1098
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] DNA Binding of Tilorone;1H NMR and Calorimetric Studies of the Intercalation (2007)
  • Author(s): Tomoki Nishimura, Naohiko Shimada, Yoichi Takeda and Kazuo Sakurai
  • Journal Title: Biochemistry Pages: 8456-8163
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Complex Made from Tetrasodium N,N-Bis(carboxylatomethyl) Glutamate and Sodium Oleate that Forms a Highly Ordered Lamella in Gel Phase (2007)
  • Author(s): Jeong, Yeonhwan; Uezu, Kazuya; Kobayashi, Masataka; Sakurai, Shinichi; Masunaga, Hiroyasu; Inoue, Katuaki; Sasaki, Sono; Shimada, Naohiko; Takeda, Yoichi; Kaneko, Kenji; Sakurai, Kazuo
  • Journal Title: Bulletin of the Chemical Society of Japan 80(2) Pages: 410-417
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Complex Made from N, N-Bis(carboxymethyl)Glutamate Tetrasodium Salt and Sodium Oleate that Forms a Highly Ordered Lamella in Gel Phase. Jeong (2007)
  • Author(s): Y. Uezu. K. Sakurai, S. Masunaga, H. Inoue, K. Sasaki, S. Shimada, N. Takeda, Y. Kaneko, K. Sakurai, K
  • Journal Title: Bull. Chem. Soc. Jpn 80(2) Pages: 410-417
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Ternary Complex Consisting of DNA, Polycation, and a Natural Polysaccharide of Schizophyllan to Induce Cellular Uptake by Antigen Presenting Cells (2007)
  • Author(s): Yoichi, Takeda, Naohiko, Shimada, Kenji, Kaneko, Seiji, Shinkai, Kazuo, Sakurai
  • Journal Title: Biomacromolecules 2(3) Pages: 641-650
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] DNA Conformational Switching by Use of an Intercalator and Its Receptor (2007)
  • Author(s): Tomoki, Nishimura, Yoichi, Takeda, Naohiko, Shimada, Kazuo, Sakurail
  • Journal Title: Chemistry Letters 36(3) Pages: 388-389
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Instantaneous Inclusion of a Polynucleotide and Hydrophobic Guest Molecules into a Helical Core of Cationic -1, 3-Glucan Polysaccharide (2007)
  • Author(s): Ikeda, M. Hasegawa, T. Numata, M. Sugikawa, K. Sakurai, K. Fujiki, M. Shinkai, S
  • Journal Title: J. Am. Chem. Soc 129(13) Pages: 3979-3988
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Salt-Concentration Dependence of the Structure and Form Factors for the Wormlike-Micelle Made from LES/AMPB Dual-Surfactant in Aqueous Solution (2007)
  • Author(s): Kenichi, Eguchi, Isamu, Kaneda, Yoshiko, Hiwatari, Hiroyasu, Masunagac, Kazuo, Sakurai
  • Journal Title: J. Applied Crystallography 40 Pages: 264-268
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A Polysaccharide Carrier to Effectively Deliver Native Phosphodiester CpG DNA to APCs (2007)
  • Author(s): Naohiko, Shimada, Cevayir, Coban, Yoichi, Takeda, Masami, Mizu, Jusaku, Minari, Takahisa, Anada, Yuichi, Torii, Seiji, Shinkai, Shizuo, Akira, Ken, J. Ishii, Kazuo, Sakurai
  • Journal Title: Bioconjugate Chem Pages: 1136-1140
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Delivery of Antisense Oligonucleotides to Nuclear Telomere RNA by Use of a Complex between Polysaccharide and Polynucleotide (2007)
  • Author(s): Jusaku, Minari, Takanori, Kubo, Hideki, Ohba, Naohiko, Shimada, Yoich, Takeda, Ryouji, Karinaga, Takahisa, Anada, Kazuya, Koumoto, Takeshi, Kawazu, Takeshi, Nagasaki, Seiji, Shinkai, Kazuo, Sakurai
  • Journal Title: Bull. Chem. Soc. Jpn 80(6) Pages: 1091-1098
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] DNA Binding of Tilorone ; 1H NMR and Calorimetric Studies of the Intercalation (2007)
  • Author(s): Tomoki, Nishimura, Naohiko, Shimada, Yoichi, Takeda, Kazuo, Sakurai
  • Journal Title: Biochemistry Pages: 8156-8163
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] An enantiomeric nanoscale architecture obtained from a pseudoenantiomeric aggre gate:Covalent fixation of helical chirality formed in self-assembled discotic triazine triamides by chiral amplification (2006)
  • Author(s): Ishi-i, Tsutomu; Kuwahara, Rempei; Takata, Akihiko; Jeong, Yeonhwan; Sakurai, Kazuo; Mataka, Shuntaro.
  • Journal Title: Chemistry European Journal 12(3) Pages: 763-776
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Click chemistry on curdlan:A regioselective and quantitative ap proach to develop artificial b-1,3-Glucans with various functiona I appendages (2006)
  • Author(s): Hasegawa, Teruaki; Umeda, Mariko; Numata, Munenori; Fujisawa, Tomohisa; Haraguchi, Shuichi; Sakurai, Kazuo; Shinkai, Seiji.
  • Journal Title: Chemistry Letters 35(1 Pages: 82-83
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Galactose-PEG dual conjugation of b-(1,3)-D-glucan schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake (2006)
  • Author(s): Karinaga, Ryouji; Anada, Takahisa; Minari, Jusaku; Mizu, Masami; Koumoto, Kazuya; Fukuda, Junji; Nakazawa, Kohji; Hasegawa, Teruaki; Numata, Munenori; Shinkai, Seiji; Sakurai, Kazuo
  • Journal Title: Biomaterials 27(8) Pages: 1626-1635
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] CpG DNA/zymosan complex to enhance cytokine secretion owing to the cocktail effect (2006)
  • Author(s): Anada, Takahisa; Okada, Naoko; Minari, Jusaku; Karinaga, Ryouji; Mizu, Masami; Koumoto, Kazuya; Shinkai, Seiji; Sakurai, Kazuo
  • Journal Title: Bioorganic&Medicinal Chemistry Letters 16(5) Pages: 1301-1304
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 計算化学を用いた多糖/核酸複合体の構造検討 (2006)
  • Author(s): 三好 賢太郎、上江洲 一也、櫻井 和朗、新海 征治
  • Journal Title: 高分子論文集 63(7) Pages: 451-457
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 多糖、核酸複合体を利用したアンチセンスDNAの肝細胞への効果的なデリバリー (2006)
  • Author(s): 狩長 亮二、三成 寿作、櫻井 和朗、新海 征治
  • Journal Title: 高分子論文集 63(7) Pages: 468-475
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Polyrotaxane/DNA Conjugate by Use of Intercalation; Bridge Formation between DNA Double Helices (2006)
  • Author(s): Kenji Tokuhsia, Emi Hamada, Ryouji Karinaga, Shinichi Kawasaki, and_Kazuo Sakurai
  • Journal Title: Macromolecules Pages: 9480-9482
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Synthesis and in Vitro Characterization of Antigen-Conjugated Polysaccharide as a CpG DNA Carrier (2006)
  • Author(s): Shimada, N.; Ishii, K.J.; Takeda, Y.; Coban, C.; Torii, Y; Shinkai, S.; Akira, S.; Sakurai, Kazuo
  • Journal Title: Bioconjug Chem 17(5) Pages: 1136-1140
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] An enantiomeric nanoscale architecture obtained from a pseudoenantiomeric aggregate:Covalent fixation of helical chirality formed in self-assembled discotic triazine triamides by chiral amplification (2006)
  • Author(s): Ishi-i, Tsutomu; Kuwahara, Rempei; Takata, Akihiko; Jeong, Yeonhwan; Sakurai, Kazuo; Mataka, Shuntaro.
  • Journal Title: Chemistry European Journal 12(3) Pages: 763-776
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Encapsulation of Ferricytochrome c into the Nano-particle Made from a Natural Polysaccharide:Schizophyllan (2006)
  • Author(s): Kasuga, Mika; Shimada, Naohiko; Takeda, Yoichi; Shinkai, Seiji; Sakurai, Kazuo.
  • Journal Title: Chemistry Letters 35(1) Pages: 763-776
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Galactose-PEG dual conjugation of b-(1,3)-D-glucan schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake (2006)
  • Author(s): Karinaga, Ryouji; Anada, Takahisa; Minari, Jusaku; Mizu, Masami; Koumoto, Kazuya; Fukuda, Junji; Nakazawa, Kohji; Hasegawa, Teruaki; Numata, Munenori; Shinkai, Seiji; Sakurai, Kazuo
  • Journal Title: Biornaterials 27(8) Pages: 1626-1635
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] An enantiomeric nanoscale architecture obtained from a pseudoenantiomeric aggregate : Covalent fixation of helical chirality formed in self-assembled discotic triazine triamides by chiral amplification (2006)
  • Author(s): Ishi-i, Tsutomu, Kuwahara, Rempei, Takata, Akihiko, Jeong, Yeonhwan, Sakurai, Kazuo, Mataka, Shuntaro
  • Journal Title: Chemistry European Journal 12(3) Pages: 763-776
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Click chemistry on curdlan : A regioselective and quantitative approach to develop artificial b-1, 3-Glucans with various functional appendages (2006)
  • Author(s): Hasegawa, Teruaki, Umeda, Mariko, Numata, Munenori, Fujisawa, Tomohisa, Haraguchi, Shuichi, Sakurai, Kazuo, Shinkai, Seiji
  • Journal Title: Chemistry Letters 35(1) Pages: 82-83
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Galactose-PEG dual conjugation of b-(1, 3)-D-glucan schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake (2006)
  • Author(s): Karinaga, Ryouji, Anada, Takahisa, Minari, Jusaku, Mizu, Masami, Koumoto, Kazuya, Fukuda, Junji, Nakazawa, Kohji, Hasegawa, Teruaki, Numata, Munenori, Shinkai, Seiji, Sakurai, Kazuo
  • Journal Title: Biomaterials 27(8) Pages: 1626-1635
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CpG DNA/zymosan complex to enhance cytokine secretion owing to the cocktail effect (2006)
  • Author(s): Anada, Takahisa, Okada, Naoko, Minari, Jusaku, Karinaga, Ryouji, Mizu, Masami, Koumoto, Kazuya, Shinkai, Seiji, Sakurai, Kazuo
  • Journal Title: Bioorganic & Medicinal Chemistry Letters 16(5) Pages: 1301-1304
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structural Examination of Polysaccharide/Nucleic Acid Complex by Computational Chemistry (2006)
  • Author(s): Kentaro MIYOSHI, Kazuya, UEZU, Kazuo, SAKURAI, Seiji, SHINKAI
  • Journal Title: Kobunshi Ronbunshu 63(7) Pages: 451-457
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effective Antisense DNA Delivery by use of a Polysaccharide/ Polynucleotide Complex (2006)
  • Author(s): Ryouji, KARINAGA, Jusaku, MINARI, Kazuo, SAKURAI, Seiji, SHINKAI
  • Journal Title: Kobunshi Ronbunshu 63(7) Pages: 468-475
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Polyrotaxane/DNA Conjugate by Use of Intercalation ; Bridge Formation between DNA Double Helices (2006)
  • Author(s): Kenji, Tokuhisa, Emi, Hamada, Ryouji, Karinaga, Shinichi, Kawasaki, Kazuo, Sakurai
  • Journal Title: Macromolecules Pages: 9480-9485
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Complex Made from Tetrasodium N, N-Bis(carboxylatomethyl)Glutamate and Sodium Oleate that Forms a Highly Ordered Lamella in Gel Phase (2006)
  • Author(s): Jeong, Yeonhwan, Uezu, Kazuya, Kobayashi, Masataka, Sakurai, Shinichi, Masunaga, Hiroyasu, Inoue, Katuaki, Sasaki, Sono, Shimada, Naohiko, Takeda, Yoichi, Kaneko, Kenji, Sakurai, Kazuo
  • Journal Title: Bulletin of the Chemical Society of Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synthesis and in Vitro Characterization of Antigen-Conjugated Polysaccharide as a CpG DNA Carrier. Shimada (2006)
  • Author(s): N. Ishii, K. J. Takeda, Y. Coban, C. Torii, Y. Shinkai, S. Akira, S. Sakurai, Kazuo
  • Journal Title: Bioconjug Chem 17,(5) Pages: 1136-1140
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Encapsulation of Ferricytochrome c into the Nana-particle Made from a Natural Polysaccharide : Schizophyllan (2006)
  • Author(s): Kasuga, Mika, Shimada, Naohiko, Takeda, Yoichi, Shinkai, Seiji, Sakurai, Kazuo
  • Journal Title: Chemistry Letters 35(1) Pages: 82-83
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 'Click chemistry' on polysaccharides:a convenient,general,and monitor approach to develop(1,3)-b-D-glucans with various functional appendages (2005)
  • Author(s): Hasegawa, Teruaki; Umeda, Mariko; Numata, Munenori; Li, Chun; Bae, Ah-Hyun; Fujisawa, Tomohisa; Haraguchi, Shuichi; Sakurai, Kazuo; Shinkai, Seiji
  • Journal Title: Carbohydrate Research 341(1) Pages: 35-40
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Transition from a Normal to Inverted Cylinder for an Amidine-Bearing Lipid/pDNA Complex and Its Excellent Transfection (2005)
  • Author(s): Koiwai, Kazunori; Tokuhisa, Kenji; Karinaga, Ryouji; Kudo, Yasuya; Kusuki, Shota; Takeda, Yoichi; Sakurai, Kazuo
  • Journal Title: Bioconjugate Chemistry 16(6) Pages: 1349-1351
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Oligosilane-Nanofibers Can Be Prepared through Fabrication of Permethyldecasilane within a Helical Superstructure of Schizophyllan (2005)
  • Author(s): Haraguchi, Shuichi; Hasegawa, Teruaki; Numata, Munenori; Fujiki, Michiya; Uezu, Kazuya; Sakurai, Kazuo; Shinkai, Seiji.
  • Journal Title: Organic Letters 7(25) Pages: 5605-5608
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Poly(diacetylene)nanofibers can be fabricated through photo-irradiation using natural polysaccharide schizophyllan as a one-dimensional mold (2005)
  • Author(s): Hasegawa, Teruaki; Haraguchi, Shuichi; Numata, Munenori; Li, Chun; Bae, Ah-Hyun; Fujisawa, Tomohisa; Kaneko, Kenji; Sakurai, Kazuo; Shinkai, Seiji
  • Journal Title: Organic&Biomolecular Chemistry 3(24) Pages: 4321-4328
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Water-soluble poly(3,4-ethylenedioxythiophene)nanocomposites created by a templating effect of b-1,3-glucan schizophyllan (2005)
  • Author(s): Li, Chun; Numata, Munenori; Hasegawa, Teruaki; Fujisawa, Tomohisa; Haraguchi, Shuichi; Sakurai, Kazuo; Shinkai, Seiji
  • Journal Title: Chemistry Letters 34(11) Pages: 1532-1533
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Water-soluble Poly-thiophene as an optical probe for detection of the helicity and conformational transition in polysaccharides (2005)
  • Author(s): Li, Chun; Numata, Munenori; Hasegawa, Teruaki; Sakurai, Kazuo; Shinkai, Seiji
  • Journal Title: Chemistry Letters 34(10) Pages: 1354-1355
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Linear double-stranded DNA that mimics an infective tail of virus genome to enhance transfection (2005)
  • Author(s): Anada, Takahisa; Karinaga, Ryouji; Koumoto, Kazuya; Mizu, Masami; Nagasaki, Takeshi; Kato, Yoshio; Taira, Kazunari; Shinkai, Seiji; Sakurai, Kazuo
  • Journal Title: Journal of Controlled Release 108(2-3) Pages: 529-539
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cholesterol-appended b-(1,3)-D-glucan schizophyllan for antisens e oligonucleotides delivery to enhance the cellular uptake (2005)
  • Author(s): Koumoto, Kazuya; Mizu, Masami; Anada, Takahisa; Nagasaki, Takeshi; Shinkai, Seiji; Sakurai, Kazuo
  • Journal Title: Bulletin of the Chemical Society of Japan 78(10) Pages: 1821-1830
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] β-1,3-Glucan polysaccharide can act as a one-dimensional host to create novel silica nanofiber structures (2005)
  • Author(s): Numata, Munenori; Li, Chun; Bae, Ah-Hyun; Kaneko, Kenji; Sakurai, Kazuo; Shinkai, Seiji
  • Journal Title: Chemical Cormnunications(Cambridge, United Kingdom) Pages: 4655-4657
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Polysaccharide-Polynucleotide Complexes.Part 32.Structural Analysis of the Curdlan/Poly(cytidylic acid)Complex with Semiempirical Molecular Orbital Calculations (2005)
  • Author(s): Miyoshi, Kentaro; Uezu, Kazuya; Sakurai Kazuo; Shinkai, Seiji.
  • Journal Title: Biotnacromolecules 6(3) Pages: 1540-1546
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Schizophyllan acts as a one-dimensional host to accommodate 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrinato-zinc to produce its fibrous super-structure (2005)
  • Author(s): Hasegawa, Teruaki; Fujisawa, Tomohisa; Numata, Munenori; Li, Chun; Bae, Ah-hyun; Haraguchi, Shuichi; Sakurai, Kazuo; Shinkai, Seiji.
  • Journal Title: Chemistry Letters 34(8) Pages: 1118-1119
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Transferrin-appended b-(1R3)-D-glucan schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake (2005)
  • Author(s): Anada, Takahisa; Karinaga, Ryouji; Mizu, Masami; Koumoto, Kazuya; Matsumoto, Takahiro; Numata, Munenori; Shinkai, Seiji; Sakurai, Kazuo
  • Journal Title: e-Journal of Surface Science and Nanotechnology 3 Pages: 195-202
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Parallel vs.anti-parallel orientation in a curdlan/oligo(dA)complex as estimated by a FRET technique (2005)
  • Author(s): Numata, Munenori; Koumoto, Kazuya; Mizu, Masami; Sakurai, Kazuo; Shinkai, Seiji.
  • Journal Title: Organic&Biomolecular Chemistry 3(12) Pages: 2255-2261
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A new polynucleotide-polysaccharide complex and its application to functional oligonucleotide delivery (2005)
  • Author(s): Anada, Takahisa; Sakurai, Kazuo; Shinkai, Seiji.
  • Journal Title: Trends in Glycoscience and Glycotechnology 17(94) Pages: 49-57
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Poly(N-substituted-acrylamide)-branched schizophyllan are useful for selective recovery of homopolynucleotides through convenient and quick precipitation procedures (2005)
  • Author(s): Matsumoto, Takahiro; Umeda, Mariko; Numata, Munenori; Hasegawa, Teruaki; Sakurai, Kazuo; Koumoto, Kazuya; Shinkai, Seiji
  • Journal Title: Polymer Journal(Tokyo, Japan) 37(3) Pages: 177-185
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] In situ monitoring of polysaccharide-polynucleotide interaction using a schizophyllan-immobilized QCM device (2005)
  • Author(s): Yang, Do-Hyeon; Bae, Ah-Hyun; Koumoto, Kazuya; Lee, Seung-Woo; Sakurai, Kazuo; Shinkai, Seiji
  • Journal Title: Sensors and Actuators, B:Chemical B105(2) Pages: 490-494
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Competition between polysaccharide/polynucleotide complexation vs.polynucleotide hybridization;salt concentration dependence of the reaction direction (2005)
  • Author(s): Karinaga, Ryouji; Koumoto, Kazuya; Minari, Jusaku; Mizu, Masami; Anada, Takahisa; Sakurai, Kazuo; Shinkai, Seiji
  • Journal Title: e-Journal of Surface Science and Nanotechnology 3 Pages: 38-45
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Small-Angle X-ray Scattering from Multi-walled Carbon Nanotu bes(CNTs)Dispersed in Polymeric Matrix (2005)
  • Author(s): Toru Inada, Hiroyasu Masunaga, Shinichi Kawasaki, Masahiro Yamada, and Kazuo Sakurai
  • Journal Title: Chern Lett 34 Pages: 524-525
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Inclusion of Cut and As-grown Single-walled Carbon Nanotubes in the Helical Superstructure of Schizophyllan and Curdlan(β-1,3-Glucans) (2005)
  • Author(s): Munenori Numata, Masayoshi Asai, Kenji Kaneko, Teruaki Hasegawa, Kazuo Sakurai and Seiji Shinkai
  • Journal Title: J.Am.Chem.Soc 127(16) Pages: 5875-5884
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Self-assembly of supramolecular chiral insulated molecular wire (2005)
  • Author(s): Chun Li, Munenori Numata, Ah-Hyun Bae, Kazuo Sakurai and Seiji Shinkai
  • Journal Title: J.Am.Chem.Soc 127(13) Pages: 4548-4589
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] PEG-appended β-(1→3)-D-glucan schizophyllan for antisense-olig onucleotides delivery to induce endosomal escape (2005)
  • Author(s): Ryouji Karinaga, Kazuya Koumoto, Masami Mizu, Takahisa Anada, Seiji Shinkai and Kazuo Sakurai
  • Journal Title: Biomaterial 26(23) Pages: 4866-4873
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] One-dimensional Arrangement of Au Nanoparticles Utilizing a Helical Structure Constructed by Schizophyllan:A Unique Encounter of a Natural Product with Inorganic Compounds (2005)
  • Author(s): Ah-Hyun Bae, Munenori Numata, Teruaki Hasegawa, Chun Li, Kenji Kaneko, Kazuo Sakurai and Seiji Shinkai
  • Journal Title: Angew.Chem.Int.Ed 44(13) Pages: 2030-2033
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Small-Angle X-ray Scattering from a Dual-Component Organogel to Exhibit a Charge Transfer Interaction (2005)
  • Author(s): Yeonhwan Jeong, Arianna Friggeri, Isamu Akiba, Hiroyasu Masunaga, Kazuo Sakurai, Shinichi Saukai, Shigeru Okamoto, Katuski Inoue and Seiji Shinkai
  • Journal Title: J.of Colloid and Interface Science 283 Pages: 113-122
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A Separation Technique for Messenger RNAs by Use of Schizophyllan/poly(A)tail Complexation (2005)
  • Author(s): Taro Kimura, Akiko Beppu, Kazuo Sakurai and Seiji Shinkai
  • Journal Title: Biornacromolecules 6 Pages: 174-179
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier (2005)
  • Author(s): Teruaki Hasegawa, Tomohisa Fujisawa, Shuichi Haraguchi, Munenori Numata, Ryouji Karinaga, Taro Kimura, Shiro Okumura, Kazuo Sakurai and Seiji Shinkai.
  • Journal Title: Bioorg.Med.Chem.Lett 15(2) Pages: 327-330
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Schizophyllan Can Act as a One-Dimensional Host to Construct Poly(diacetylene)Nanofibers (2005)
  • Author(s): Teruaki Hasegawa, Shuichi Haraguchi, Munenori. Numata, Tomohisa Fujisawa, Chun Li, Kenji Kaneko, Kazuo Sakurai and Seiji Shinkai
  • Journal Title: Chem.Lett 34 Pages: 40-41
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Inclusion of DNA into Organic Gelator Fibers Made of Amphipathic Molecules and Its Controlled Release (2005)
  • Author(s): Karinaga, Ryouji; Jeong, Yeonhwan; Shinkai, Seiji; Kaneko, Kenji; Sakurai, Kazuo
  • Journal Title: Langmuir 21(21) Pages: 9398-9401
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Solvent/Gelator Interactions and Supramolecular Structure of Gel-F Iibers in Cyclic Bis-Urea/Primary Alcohol Organogels (2005)
  • Author(s): Yeonhwan Jeong, Kenji Hanabusa, Hiroyasu Masunaga, Isamu Akiba, Kentaro Miyoshi, Shinichi Sakurai and Kazuo Sakurai
  • Journal Title: Langmuir 21(2) Pages: 586-594
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Click chemistry' on polysaccharides : a convenient, general, and monitor approach to develop(1, 3)-b-D-glucans with various functional appendages (2005)
  • Author(s): Hasegawa, Teruaki, Umeda, Mariko, Numata, Munenori, Li, Chun, Bae, Ah-Hyun, Fujisawa, Tomohisa, Haraguchi, Shuichi, Sakurai, Kazuo, Shinkai, Seiji
  • Journal Title: Carbohydrate Research 341(1) Pages: 35-40
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transition from a Normal to Inverted Cylinder for an Amidine-Bearing Lipid/pDNA Complex and Its Excellent Transfection (2005)
  • Author(s): Koiwai, Kazunori, Tokuhisa, Kenji, Karinaga, Ryouji, Kudo, Yasuya, Kusuki, Shota, Takeda, Yoichi, Sakurai, Kazuo
  • Journal Title: Bioconjugate Chemistry 16(6) Pages: 1349-1351
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oligosilane-Nanofibers Can Be Prepared through Fabrication of Permethyldecasilane within a Helical Superstructure of Schizophyllan (2005)
  • Author(s): Haraguchi, Shuichi, Hasegawa, Teruaki, Numata, Munenori, Fujiki, Michiya, Uezu, Kazuya, Sakurai, Kazuo, Shinkai, Seiji
  • Journal Title: Organic Letters 7(25) Pages: 5605-5608
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Poly(diacetylene)nanofibers can be fabricated through photo-irradiation using natural polysaccharide schizophyllan as a one-dimensional mold (2005)
  • Author(s): Hasegawa, Teruaki, Haraguchi, Shuichi, Numata, Munenori, Li, Chun, Bae, Ah-Hyun, Fujisawa, Tomohisa, Kaneko, Kenji, Sakurai, Kazuo, Shinkai, Seiji
  • Journal Title: Organic & Biomolecular Chemistry 3(24) Pages: 4321-4328
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Water-soluble poly(3, 4-ethylenedioxythiophene)nanocomposites created by a templating effect of b-1, 3-glucan schizophyllan (2005)
  • Author(s): Li, Chun, Numata, Munenori, Hasegawa, Teruaki, Fujisawa, Tomohisa, Haraguchi, Shuichi, Sakurai, Kazuo, Shinkai, Seiji
  • Journal Title: Chemistry Letters 34(11) Pages: 1532-1533
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Water-soluble Poly-thiophene as an optical probe for detection of the helicity and conformational transition in polysaccharides (2005)
  • Author(s): Li, Chun, Numata, Munenori, Hasegawa, Teruaki, Sakurai, Kazuo, Shinkai, Seiji
  • Journal Title: Chemistry Letters 34(10) Pages: 1354-1355
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Linear double-stranded DNA that mimics an infective tail of virus genome to enhance transfection (2005)
  • Author(s): Anada, Takahisa, Karinaga, Ryouji, Koumoto, Kazuya, Mizu, Masami, Nagasaki, Takeshi, Kato, Yoshio, Taira, Kazunari, Shinkai, Seiji, Sakurai, Kazuo
  • Journal Title: Journal of Controlled Release 108(2-3) Pages: 529-539
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cholesterol-appended b-(1, 3)-D-glucan schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake (2005)
  • Author(s): Koumoto, Kazuya, Mizu, Masami, Anada, Takahisa, Nagasaki, Takeshi, Shinkai, Seiji, Sakurai, Kazuo
  • Journal Title: Bulletin of the Chemical Society of Japan 78(10) Pages: 1821-1830
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] β-1, 3-Glucan polysaccharide can act as a one-dimensional host to create novel silica nanofiber structures (2005)
  • Author(s): Numata, Munenori, Li, Chun, Bae, Ah-Hyun, Kaneko, Kenji, Sakurai, Kazuo, Shinkai, Seiji
  • Journal Title: Chemical Communications(Cambridge, United Kingdom) 37 Pages: 4655-4657
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Polysaccharide-Polynucleotide Complexes. Part 32. Structural Analysis of the Curdlan/Poly(cytidylic acid) Complex with Semiempirical Molecular Orbital Calculations (2005)
  • Author(s): Miyoshi, Kentaro, Uezu, Kazuya, Sakurai, Kazuo, Shinkai, Seiji
  • Journal Title: Biomacromolecules 6(3) Pages: 1540-1546
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Schizophyllan acts as a one-dimensional host to accommodate 5, 10, 15, 20-tetrakis(4-carboxyphenyl)porphyrinato-zinc to produce its fibrous super-structure (2005)
  • Author(s): Hasegawa, Teruaki, Fujisawa, Tomohisa, Numata, Munenori, Li, Chun, Bae, Ah-hyun, Haraguchi, Shuichi, Sakurai, Kazuo, Shinkai, Seiji
  • Journal Title: Chemistry Letters 34(8) Pages: 1118-1119
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transferrin-appended b-(1R3)-D-glucan schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake (2005)
  • Author(s): Anada, Takahisa, Karinaga, Ryouji, Mizu, Masami, Koumoto, Kazuya, Matsumoto, Takahiro, Numata, Munenori, Shinkai, Seiji, Sakurai, Kazuo
  • Journal Title: e-Journal of Surface Science and Nanotechnology 3 Pages: 195-202
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Parallel vs. anti-parallel orientation in a curdlan/oligo(dA)complex as estimated by a FRET technique (2005)
  • Author(s): Numata, Munenori, Koumoto, Kazuya, Mizu, Masami, Sakurai, Kazuo, Shinkai, Seiji
  • Journal Title: Organic & Biomolecular Chemistry 3(12) Pages: 2255-2261
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A new polynucleotide-polysaccharide complex and its application to functional oligonucleotide delivery (2005)
  • Author(s): Anada, Takahisa, Sakurai, Kazuo, Shinkai, Seiji
  • Journal Title: Trends in Glycoscience and Glycotechnology 17(94) Pages: 49-57
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Poly(N-substituted-acrylamide)-branched schizophyllans are useful for selective recovery of homopolynucleotides through convenient and quick precipitation procedures (2005)
  • Author(s): Matsumoto, Takahiro, Umeda, Mariko, Numata, Munenori, Hasegawa, Teruaki, Sakurai, Kazuo, Koumoto, Kazuya, Shinkai, Seiji
  • Journal Title: Polymer Journal(Tokyo, Japan) 37(3) Pages: 177-185
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] In situ monitoring of polysaccharide - polynucleotide interaction using a schizophyllan-immobilized QCM device (2005)
  • Author(s): Yang, Do-Hyeon, Bae, Ah-Hyun, Koumoto, Kazuya, Lee, Seung-Woo, Sakurai, Kazuo, Shinkai, Seiji
  • Journal Title: Sensors and Actuators, B : Chemical B105(2) Pages: 490-494
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Competition between polysaccharide/polynucleotide complexation vs. polynucleotide hybridization ; salt concentration dependence of the reaction direction (2005)
  • Author(s): Karinaga, Ryouji, Koumoto, Kazuya, Minari, Jusaku, Mizu, Masami, Anada, Takahisa, Sakurai, Kazuo, Shinkai, Seiji
  • Journal Title: e-Journal of Surface Science and Nanotechnology 3 Pages: 38-45
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inclusion of DNA into Organic Gelator Fibers Made of Amphipathic Molecules and Its Controlled Release (2005)
  • Author(s): Karinaga, Ryouji, Jeong, Yeonhwan, Shinkai, Seiji, Kaneko, Kenji, Sakurai, Kazuo
  • Journal Title: Langmuir 21(21) Pages: 9398-9401
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Solvent/Gelator Interactions and Supramolecular Structure of Gel-Fibers in Cyclic Bis-Urea/Primary Alcohol Organogels (2005)
  • Author(s): Yeonhwan, Jeong, Kenji, Hanabusa, Hiroyasu, Masunaga, Isamu, Akiba, Kentaro, Miyoshi, Shinichi, Sakurai, Kazuo, Sakurai
  • Journal Title: Langmuir 21(2) Pages: 586-594
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] An Oligonucleotide Carrier Based on β-1, 3-Glucan (2005)
  • Author(s): K. Sakurai, S. Shinkai
  • Journal Title: Non-viral Gene Therapy : Gene Design and Derivery
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] β-1,3-Glucan(schizophyllan)can act as a one-dimensional host for creation of novel poly(aniline)nano-fiber structures (2004)
  • Author(s): Munenori Numata, Teruaki Hasegawa, Tomohis a Fujisawa, Kazuo Sakurai and Seiji Shinkai.
  • Journal Title: Org.Lett 6(24) Pages: 4447-4450
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Schizophyllans carrying oligosaccharide-appendages as potential candidates for cell-targeted antisense carrier (2004)
  • Author(s): Teruaki Hasegawa, a Tomohisa Fujisawa, a Munenori Numata, a Takahiro Matsumoto, a Mariko Umeda, a Ryouji Karinaga, Masami Mizu, Kazuya Koumoto, Taro Kimura, Shiro Okumura, Kazuo Sakurai and Seiji Shinkai
  • Journal Title: Organic and biomolecular 2 Pages: 3091-3098
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Proposal of New Modification Technique for Linear Double-Stranded DNAs Using the Polysaccharide Schizopyllan (2004)
  • Author(s): Takahisa Anada, Hideshi Matsunaga, Ryouji Karinaga, Kazuya Koumoto, Masami Mizu, Koji Nakano, Seiji Shinkai and Kazuo Sakurai
  • Journal Title: Bioorganic&Medicinal Chemistry Letters 14 Pages: 5655-5659
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Single-Walled Carbon Nanotubes Acquire a Specific Lectin-affinity through Supramolecular Wrapping with Lactose-appended Schizophyllan (2004)
  • Author(s): Teruaki Hasegawa, Tomohisa Fujisawa, Munenori Numata, Mariko Umeda, Takahiro Matsumoto, Taro Kimura, Shiro Okumura, Kazuo Sakurai and Seiji Shinkai
  • Journal Title: Chem.Commun Pages: 2150-2151
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Rod-like architecture and helicity of the poly(C)/schizophyllan complex as observed by AFM and SEM (2004)
  • Author(s): H.Bae, S.W.Lee, M.Ikeda, M.Sano, S.Shinkai, K.Sakurai
  • Journal Title: Carbohyd.Res 339 Pages: 251-258
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Chemically modified polysaccharide schizophyllan for antisense olig onucleotides delivery to enhance the cellular uptake efficiency (2004)
  • Author(s): T.Matsumoto, M.Numata, T.Anada, M.Mizu, K.Koumoto, K.Sakurai, T.Nagasaki, S.Shinkai
  • Journal Title: Biochina.Biophys.Acta 1670 Pages: 91-104
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Curdlan and Schizophyllan(β-1,3-Glucans)can Entrap Single-wall Carbon Nanotubes in Their Helical Superstructure (2004)
  • Author(s): M.Numata, M.Asai, K.Kaneko, T.Hasegawa, N.Fujita, Y.Kitada, K.Sakurai, S.Shinkai
  • Journal Title: Chem.Lett Pages: 232-233
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Lactose-appended schizophyllan as a potential candidate for hep atocyte-targetted antisense carrier (2004)
  • Author(s): T.Hasegawa, M.Umeda, T.Matsumoto, M.Numata, M.Mizu, K.Koumoto, K.Sakurai, S.Shinkai.
  • Journal Title: Chem.Commun Pages: 382-383
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Polysaccharide/polynucleotide complexes part 6:Complementary-strand-induced release of single-stranded DNA bound in the schizophyllan complex (2004)
  • Author(s): K.Koumoto, M.Mizu, K.Sakurai, T.Kunitake, S.Shinkai.
  • Journal Title: Chemistry&Biodiversity 1 Pages: 520-529
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Enhancement of the antisense effect of polysaccharide-polynucleotide complexes by preventing the antisense oligonucleotide from binding to proteins in the culture medium (2004)
  • Author(s): M.Mizu, K.Koumoto, T.Anada, R.Karinaga, T.Kimura, T.Nagasaki, S.Shinkai, K.Sakurai
  • Journal Title: Bull.Chem.Soc.Jpn 77 Pages: 1101-1110
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] First observation of complexation between mRNA and the natural polysacc haride schizophyllan by the fluorescence polarization (2004)
  • Author(s): R.Karinaga, M.Mizu, K.Koumoto, T.Anada, S.Shinkai, K.Sakurai
  • Journal Title: Chemisby&Biodiversity 1 Pages: 634-369
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Removal of the side-chain glucose groups from schizophyllan improves the thermal stability of the polycytidylic acid complexes under the physiological conditions (2004)
  • Author(s): K.Koumoto, R.Karinaga, M.Mizu, T.Anada, K.Sakurai, T.Kunitake, S.Shinkai
  • Journal Title: Biopolymers 75 Pages: 403-411
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Lactose-appended schizophyllan is a potential candidate for hepatocyte-targetted antisense carrier (2004)
  • Author(s): Teruaki Hasegawa, Mariko Umeda, Takahiro Matsumoto, Munenori Numata, Masami Mizu, Kazuya Koumoto, Kazuo Sakurai and Seiji Shinkai
  • Journal Title: Chern.Comrnun Pages: 382-383
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Release of Single-stranded DNA Bound in the Schizophyllan Complex towand the Complementary Strand (2004)
  • Author(s): Kazuya Koumoto, Masami Mizu, Kazuo Sakurai, Toyoki Kunitake and Seiji Shinkai.
  • Journal Title: Chemistry&Biodiversity 1 Pages: 520-529
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Protection of polynucleotides against nuclease-mediated hydrolysis by complexation with schizophyllan (2004)
  • Author(s): M.Mizu, K.Koumoto, T.Kimura, K.Sakurai, S.Shinkai
  • Journal Title: Biomaterials 25 Pages: 3109-3116
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A Polysaccharide Carrier for Immunostimulatory CpG DNAs to Enhance Cytokine Secretion (2004)
  • Author(s): M.Mizu, K.Koumoto, T.Anada, T.Matsumoto, M.Numata, S.Shinkai, T.Nagasaki, K.Sakurai.
  • Journal Title: J.Am.Chem.Soc 126 Pages: 8372-8373
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Protection of polynucleotides against nuclease-mediated hydrolysis by complexation with schizophyllan (2004)
  • Author(s): M. Mizu, K. Koumoto, T. Kimura, K. Sakurai, S. Shinkai
  • Journal Title: Biomaterials 25 Pages: 3109-3116
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A Polysaccharide Carrier for Immunostimulatory CpG DNAs to Enhance Cytokine Secretion (2004)
  • Author(s): M. Mizu, K. Koumoto, T. Anada, T. Matsumoto, M. Numata, S. Shinkai, T. Nagasaki, K. Sakurai
  • Journal Title: J. Am. Chem. Soc 126 Pages: 8372-8373
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Melt Behaviour of Block Copolymers(Chapter 4) (2004)
  • Author(s): S. Sakurai, S. Okamoto, K. Sakurai
  • Journal Title: Developments in Block Copolymer Science and Technology, Wiley
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Small-Angle X-Ray Scattering from Self-assembled Aggregates that form Rod-like Architecture (2004)
  • Author(s): Kazuo, Sakurai
  • Journal Title: SPring-8 Report
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A Novel Triple Helix Consisting of One Polynucleotide and Two Polysaccharide Chains (2004)
  • Author(s): Kazuo, Sakurai, Kazuya, Koumoto, Seiji, Shinkai$
  • Journal Title: Macromolecular Nanostructured Materials, Kodanasha&Ppringer Edited by N. Ueyama and A. Harada
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Small-Angle X-ray Scattering from Multi-walled Carbon Nanotubes(CNTs)Dispersed in Polymeric Matrix
  • Author(s): Toru, Inada, Hiroyasu, Masunaga, Shinichi, Kawasaki, Masahiro, Yamada, Kazuo Sakurai
  • Journal Title: Chem Left 34 Pages: 524-525
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inclusion of Cut and As-grown Single-walled Carbon Nanotubes in the Helical Superstructure of Schizophyllan and Curdlan(β-1, 3-Glucans)
  • Author(s): Munenori, Numata, Masayoshi, Asai, Kenji, Kaneko, Teruaki, Hasegawa, Kazuo, Sakurai, Seiji, Shinkai
  • Journal Title: J. Am. Chem. Soc 127(16) Pages: 5875-5884
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Self-assembly of supramolecular chiral insulated molecular wire
  • Author(s): Chun, Li, Munenori, Numata, Ah-Hyun, Bae, Kazuo, Sakurai, Seiji, Shinkai
  • Journal Title: J. Am. Chem. Soc 127(13) Pages: 4548-4589
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] PEG-appended β-(1→3)-D-glucan schizophyllan for antisense-oligonucleotides delivery to induce endosomal escape
  • Author(s): Ryouji, Karinaga, Kazuya, Koumoto, Masami, Mizu, Takahisa, Anada, Seiji, Shinkai, and Kazuo, Sakurai
  • Journal Title: Biomaterials 26(23) Pages: 4866-4873
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] One-dimensional Arrangement of Au Nanoparticles Utilizing a Helical Structure Constructed by Schizophyllan : A Unique Encounter of a Natural Product with Inorganic Compounds
  • Author(s): Ah-Hyun, Bae, Munenori, Numata, Teruaki, Hasegawa, Chun, Li, Kenji, Kaneko, Kazuo, Sakurai, Seiji, Shinkai
  • Journal Title: Angew. Chem. Int. Ed 44(13) Pages: 2030-2033
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Small-Angle X-ray Scattering from a Dual-Component Organogel to Exhibit a Charge Transfer Interaction
  • Author(s): Yeonhwan, Jeong, Arianna, Friggeri, Isamu, Akiba, Hiroyasu, Masunaga, Kazuo, Sakurai, Shinichi, Saukai, Shigeru, Okamoto, Katuski, Inoue, Seiji, Shinkai
  • Journal Title: J. of Colloid and Interface Science 283 Pages: 113-122
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A Separation Technique for Messenger RNAs by Use of Schizophyllan/poly(A)tail Complexation
  • Author(s): Taro, Kimura, Akiko, Beppu, Kazuo Sakurai, Seiji, Shinkai
  • Journal Title: Biomacromolecules 6 Pages: 174-179
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier
  • Author(s): Teruaki, Hasegawa, Tomohisa, Fujisawa, Shuichi, Haraguchi, Munenori, Numata, Ryouji, Karinaga, Taro, Kimura, Shire, Okumura, Kazuo, Sakurai, Seiji, Shinkai
  • Journal Title: Bioorg. Med. Chem. Lett 15(2) Pages: 327-330
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Schizophyllan Can Act as a One-Dimensional Host to Construct Poly(diacetylene) Nanofibers
  • Author(s): Teruaki, Hasegawa, Shuichi, Haraguchi, Munenori. Numata, Tomohisa, Fujisawa, Chun, Li, Kenji, Kaneko, Kazuo, Sakurai, Seiji, Shinkai
  • Journal Title: Chem. Left 34 Pages: 40-41
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] β-1, 3-Glucan(schizophyllan)can act as a one-dimensional host for creation of novel poly(aniline) nano-fiber structures
  • Author(s): Munenori, Numata, Teruaki, Hasegawa, Tomohisa, Fujisawa, Kazuo, Sakurai, Seiji, Shinkai
  • Journal Title: Org. Left 6(24) Pages: 4447-4450
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Schizophyllans carrying oligosaccharide-appendages as potential candidates for cell-targeted antisense carrier
  • Author(s): Teruaki, Hasegawa, a Tomohisa, Fujisawa, a Munenori, Numata, a Takahiro, Matsumoto, a Mariko, Umeda, a Ryouji, Karinaga, Masami, Mizu, Kazuya, Koumoto, Taro, Kimura, Shire, Okumura, Kazuo, Sakurai, Seiji, Shinkai
  • Journal Title: Organic and biomolecular chemistry 2 Pages: 3091-3098
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Proposal of New Modification Technique for Linear Double-Stranded DNAs Using the Polysaccharide Schizopyllan
  • Author(s): Takahisa, Anada, Hideshi, Matsunaga, Ryouji, Karinaga, Kazuya, Koumoto, Masami, Mizu, Koji, Nakano, Seiji, Shinkai, Kazuo Sakurai
  • Journal Title: Bioorganic & Medicinal Chemistry Letters 14 Pages: 5655-5659
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Single-Walled Carbon Nanotubes Acquire a Specific Lectin-affinity through Supramolecular Wrapping with Lactose-appended Schizophyllan
  • Author(s): Teruaki, Hasegawa, Tomohisa, Fujisawa, Munenori, Numata, Mariko, Umeda, Takahiro, Matsumoto, Taro, Kimura, Shire, Okumura, Kazuo, Sakurai, Seiji, Shinkai
  • Journal Title: Chem. Commun Pages: 2150-2151
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rod-like architecture and helicity of the poly(C)/ schizophyllan complex as observed by AFM and SEM
  • Author(s): H. Bae, S. W. Lee, M. Ikeda, M. Sano, S. Shinkai, K. Sakurai
  • Journal Title: Carbohydr Res 339 Pages: 251-258
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Chemically modified polysaccharide schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake efficiency
  • Author(s): T. Matsumoto, M. Numata, T. Anada, M. Mizu, K. Koumoto, K. Sakurai, T. Nagasaki, S. Shinkai
  • Journal Title: Biochim. Biophys. Acta 1670 Pages: 91-104
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Curdlan and Schizophyllan(3-1, 3-Glucans)can Entrap Single-wall Carbon Nanotubes in Their Helical Superstructure
  • Author(s): M. Numata, M. Asai, K. Kaneko, T. Hasegawa, N. Fujita, Y. Kitada, K. Sakurai, S. Shinkai
  • Journal Title: Chem. Lett Pages: 232-233
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Lactose-appended schizophyllan as a potential candidate for hepatocyte-targetted antisense carrier
  • Author(s): T. Hasegawa, M. Umeda, T. Matsumoto, M. Numata, M. Mizu, K. Koumoto, K. Sakurai, S. Shinkai
  • Journal Title: Chem. Commun Pages: 382-383
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Polysaccharide/polynucleotide complexes part 6 : Complementary-strand-induced release of single-stranded DNA bound in the schizophyllan complex
  • Author(s): K. Koumoto, M. Mizu, K. Sakurai, T. Kunitake, S. Shinkai
  • Journal Title: Chemistry & Biodiversity 1 Pages: 520-529
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhancement of the antisense effect of polysaccharide-polynucleotide complexes by preventing the antisense oligonucleotide from binding to proteins in the culture medium
  • Author(s): M. Mizu, K. Koumoto, T. Anada, R. Karinaga, T. Kimura, T. Nagasaki, S. Shinkai, K. Sakurai
  • Journal Title: Bull. Chem. Soc. Jpn 77 Pages: 1101-1110
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] First observation of complexation between mRNA and the natural polysaccharide schizophyllan by the fluorescence polarization
  • Author(s): R. Karinaga, M. Mizu, K. Koumoto, T. Anada, S. Shinkai, K. Sakurai
  • Journal Title: Chemistry & Biodiversity 1 Pages: 634-639
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Removal of the side-chain glucose groups from schizophyllan improves the thermal stability of the polycytidylic acid complexes under the physiological conditions
  • Author(s): K. Koumoto, R. Karinaga, M. Mizu, T. Anada, K. Sakurai, T. Kunitake, S. Shinkai
  • Journal Title: Biopolymers 75 Pages: 403-411
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Lactose-appended schizophyllan is a potential candidate for hepatocyte-targetted antisense carrier
  • Author(s): Teruaki, Hasegawa, Mariko, Umeda, Takahiro, Matsumoto, Munenori, Numata, Masami, Mizu, Kazuya, Koumoto, Kazuo, Sakurai, Seiji, Shinkai
  • Journal Title: Chem. Commun Pages: 382-383
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Release of Single-stranded DNA Bound in the Schizophyllan Complex toward the Complementary Strand
  • Author(s): Kazuya, Koumoto, Masami, Mizu, Kazuo, Sakurai, Toyoki, Kunitake, Seiji, Shinkai
  • Journal Title: Chemistry & Biodiversity 1 Pages: 520-529
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] DDS粒子内のDNAの折りたたみ構造と効率の関係 (2008)
  • Author(s): 櫻井 和朗
  • Organizer: 東京大学新領域創成科学研究科セミナー
  • Place of Presentation: 東京大学
  • Year and Date: 2008-03-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 抗原提示細胞上のDectinelを標的とした核酸医薬のDDS (2007)
  • Author(s): 櫻井 和朗
  • Organizer: 第56回高分子学会討論会
  • Place of Presentation: 名古屋工業大学
  • Year and Date: 2007-09-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functional Oligonucleotides DDS Targetting to Dectin 1 on PAC (2007)
  • Organizer: SPSJ 56th Annual Meeting
  • Place of Presentation: Nagoya Institute of Technology
  • Year and Date: 2007-09-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] A Novel Cationic Lipid to Delivery DNA-Relationship between chemistry,biological function and nanostructure (2007)
  • Author(s): 櫻井 和朗
  • Organizer: Bath大学 RCSセミナー
  • Place of Presentation: Bath大学
  • Year and Date: 2007-08-17
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A Novel Cationic Lipid to Delivery DNA-Relationship between chemistry, biological function and nanostructure- (2007)
  • Organizer: RCS Seminar
  • Place of Presentation: The University of Bath
  • Year and Date: 2007-08-17
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] A. Novel Cationic Lipid to Delivery DNA-Relationship between chemistry, biological function and nanostructure- (2007)
  • Organizer: Graduate school of frontier sciences
  • Place of Presentation: The University of Tokyo seminar
  • Year and Date: 2007-03-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Delivery of Functional ODNs to Macrophages by Use of a Natural Polysaccharide of Schizophyllan (2007)
  • Author(s): 櫻井 和朗
  • Organizer: 日本中国韓国A3バイオマテリアルシンポジューム
  • Place of Presentation: 鹿児島(指宿)
  • Year and Date: 2007-02-17
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Delivery of Functional ODNs to Macrophages by Use of a Natural Polysaccharide of Schizophyllan (2007)
  • Organizer: 2nd Symposium of Asia 3 Foresight Program on Gene Delivery
  • Place of Presentation: Kagoshima, Japan
  • Year and Date: 2007-01-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 多糖、核酸からなる3重らせん複合体の性質と機能性核酸DDSへの応用 (2006)
  • Author(s): 櫻井 和朗
  • Organizer: 多糖未来シンポジューム
  • Place of Presentation: 名古屋大宅
  • Year and Date: 2006-11-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] New Triple Helix Consisting of DNA and Polysaccharides and Application to DDS (2006)
  • Organizer: 1st Polysaccharide Conference
  • Place of Presentation: Nagoya University
  • Year and Date: 2006-11-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 多糖、核酸複合体の性質と遺伝子キャリヤーへの応用 (2006)
  • Author(s): 櫻井 和朗
  • Organizer: セルロース学会西部支部シンポジューム
  • Place of Presentation: 熊本大学
  • Year and Date: 2006-10-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] DNA/Polysaccharide Complexes and Application to DDS (2006)
  • Organizer: The Cellulose Society of Japan Symposium
  • Place of Presentation: Kumamoto University
  • Year and Date: 2006-10-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] A New Triple Helix Consisting of One Polynucleotide Chain and Two Polysaccharide Chains-Application to Gene Carriers (2006)
  • Author(s): 櫻井 和朗
  • Organizer: USA-Japan DNA Workshop
  • Place of Presentation: 米国、ハワイ
  • Year and Date: 2006-08-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] FA New Triple Helix Consisting of One Polynucleotide Chain and Two Polysaccharide Chains-Application to Gene Carriers- (2006)
  • Organizer: USA-Japan DNA Workshop
  • Year and Date: 2006-08-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Molecular Design of a Low Birefringence and High Refractive-Index Polyester for Optical Lenses (2006)
  • Author(s): 櫻井 和朗
  • Organizer: Prof.Macknight Memorial Symposium
  • Place of Presentation: 米国、マサチューセッツ、アマハースト
  • Year and Date: 2006-06-05
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Molecular Design of a Low Birefringence and High Refractive-Index Polyester for Optical Lenses (2006)
  • Organizer: Prof. Macknight Memorial Symposium
  • Year and Date: 2006-06-05
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 多糖ベータ1,3グルカンをキャリヤーに用いた免疫刺激性CpGモチーフのデリバリー (2005)
  • Author(s): 櫻井 和朗
  • Organizer: 第54回高分子討論会
  • Place of Presentation: 山形大学
  • Year and Date: 2005-09-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] DDS of Immunostimulate ODN by use of DNA/Polysaccharide Complexes (2005)
  • Organizer: SPSJ 54th Annual Meeting
  • Place of Presentation: Yamagata University
  • Year and Date: 2005-09-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] アミジン基を有する脂質とDNAが作るポリイオン複合体の構造 (2005)
  • Author(s): 櫻井 和朗
  • Organizer: 日本学術会議材料研究会
  • Place of Presentation: 京都市
  • Year and Date: 2005-09-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] DNA/cationic Lipid Complexes and their Structures (2005)
  • Organizer: The Society of Materials Science
  • Place of Presentation: Kyoto city, Japan
  • Year and Date: 2005-09-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 天然多糖シゾフィランを用いた核酸医薬キャリヤーの創製 (2005)
  • Author(s): 櫻井 和朗
  • Organizer: セルロース学会
  • Place of Presentation: 九州大学医学部
  • Year and Date: 2005-07-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] DNA/Polysaccharide Complexes and Application to DDS (2005)
  • Organizer: The Cellulose Society of Japan Symposium
  • Place of Presentation: Kyushu University
  • Year and Date: 2005-07-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] An Oligonucleotide Carrier Based on β-1, 3-Glucan (2005)
  • Author(s): K.Sakurai and S.Shinkai
  • Total Pages: 487
  • Publisher: Non-viral Gene Therapy:Gene Design and Derivery
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Melt Behaviour of Block Copolymers(Chapter 4) (2004)
  • Author(s): S.Sakurai, S.Okamoto, and K.Sakurai
  • Total Pages: 367
  • Publisher: Developments in Block Copolymer Science and Technology,Wiley
  • Description: 「研究成果報告書概要(和文)」より
• [Book] A Novel Triple Helix Consisting of One Polynucleotide and Two Polysaccharide Chains (2004)
  • Author(s): Kazuo Sakurai, Kazuya Koumoto, and Seiji Shinkai
  • Total Pages: 335
  • Publisher: Macromolecular Nanostructured Materials,Kodanasha&Ppringer Edited by N.Ueyama and A.Harada
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Small-Angle X-Ray Scattering from Self-assembled Aggregates that form Rod-like Architecture 2004 SPring-8報告書 (2004)
  • Author(s): Kazuo Sakurai
  • Total Pages: 150
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 活性炭成型体及びその製造方法 (2006)
  • Inventor(s): 櫻井 和朗, 稲田 達
  • Industrial Property Rights Holder: 財団法人北九州産業学術推進機構、株式会社タカギ
  • Industrial Property Number: 特願2006-97611
  • Filing Date: 2006-03-31
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 新規デンドリマー (2006)
  • Inventor(s): 櫻井 和朗、徳久 憲司、小堀 香奈、山田 昌宏、川崎 真一、山田 光昭
  • Industrial Property Rights Holder: 大阪瓦斯株式会社
  • Industrial Property Number: 特願2006-65992
  • Filing Date: 2006-03-10
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] Th2細胞関連疾患の予防等に用いられる核酸/多糖複合体 (2006)
  • Inventor(s): 新海 征治、櫻井 和朗、嶋田 直彦、審良 静男、石井 健
  • Industrial Property Rights Holder: 独立行政法人科学技術振興機構、国立大学法人大阪大学
  • Industrial Property Number: 特願2006-282148
  • Filing Date: 2006-10-17
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 核酸/多糖/カーボンナノチューブ複合体 (2006)
  • Inventor(s): 新海 征治、沼田 宗典、広瀬 良治、櫻井 和朗
  • Industrial Property Rights Holder: 独立行政法人科学技術振興機構、三井製糖株式会社
  • Industrial Property Number: 特願2006-144929
  • Filing Date: 2006-05-25
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] アリールメチルアミン誘導体およびその塩ならびにそれを構成成分とする薬物担体 (2005)
  • Inventor(s): 櫻井 和朗、楠木 翔太、濱田 衣美、工藤 秦也、嶋田 直彦、武田 陽一、小岩井 一倫
  • Industrial Property Rights Holder: 独立行政法人科学技術振興機構、財団法人北九州産業学術推進機構、テルモ株式会社
  • Industrial Property Number: 特願2006-287855
  • Filing Date: 2005-10-23
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] マイクロチップ及びマイクロチップを用いた細胞評価方法 (2005)
  • Inventor(s): 櫻井 和朗、平野 雄、中澤 浩二
  • Industrial Property Rights Holder: 財団法人北九州産業学術推進機構
  • Industrial Property Number: 特願2005-208469
  • Filing Date: 2005-07-19
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] ゲル化剤、その製造方法およびそれを用いた固化、分離方法 (2005)
  • Inventor(s): 鄭 然桓、櫻井 和朗、上江洲 一也、河野 智謙、尾張 正典、大庭 啓彦、岩本 真司、光宗 将太、小林 正隆、波多江 修一、鶴 仁、山家 桂一、永友 義夫、梅木 久夫
  • Industrial Property Rights Holder: 株式会社古河テクノマテリアル、シャボン玉石けん株式会社、財団法人北九州産業学術推進機構
  • Industrial Property Number: 特願2005-325463
  • Filing Date: 2005-11-09
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 免疫刺激性複合体 (2005)
  • Inventor(s): 新海 征治、水 雅美、櫻井 和朗、穴田 貴久、岡田 尚子、三成 寿作
  • Industrial Property Rights Holder: 独立行政法人科学技術振興機構、三井製糖株式会社
  • Industrial Property Number: 特願2005-261634
  • Filing Date: 2005-09-09
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] メッセンジャーRNAの分離方法 (2005)
  • Inventor(s): 新海 征治、木村 太郎、櫻井 和朗
  • Industrial Property Rights Holder: 独立行政法人科学技術振興機構、福岡県
  • Industrial Property Number: 特願2005-97147
  • Filing Date: 2005-03-30
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] ハイブリッド多糖系キャリアーを用いる核酸類の導入方法 (2004)
  • Inventor(s): 新海 征治、水 雅美、櫻井 和朗、狩長 亮二、穴田 貴久、甲元 一也、長谷川 輝明、沼田 宗典
  • Industrial Property Rights Holder: 独立行政法人科学技術振興機構、三井製糖株式会社
  • Industrial Property Number: 特願2004-252009
  • Filing Date: 2004-08-31
  • Description: 「研究成果報告書概要(和文)」より