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2005 Fiscal Year Final Research Report Summary

Development of a novel micro-reactor having synthetic cell structure

Research Project

Project/Area Number 16360390
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Reaction engineering/Process system
Research InstitutionThe University of Tokyo

Principal Investigator

YAMAGUCHI Takeo  The University of Tokyo, Graduate School of Engineering, Associate Professor, 大学院・工学系研究科, 助教授 (30272363)

Project Period (FY) 2004 – 2005
Keywordsstimuli responsive materials / enzyme / microcapsule / membrane
Research Abstract

A novel type of intelligent microcapsule reactor system was prepared. The reactor can recognize environmental change and control reaction rate by itself. For the reactor system, acrylic acid (AA), N-isopropylacrylamide (NIPAM), and glucose oxidase (GOD) were selected as a pH-responsive device, a gating device according and a reaction device, respectively. Poly(NIPAM-co-AA) (P-NIPAM-co-AA) are known to change its hydrophilicity-hydrophobicity due to pH change. They were integrated in a core-shell microcapsule space. GOD was loaded inside the core space and the pores in the outside shell layer were filled with P-NIPAM-co-AA linear grafted chains as pH-responsive gates. When P-NIPAM-co-AA gates are hydrophilic at high pH value, this microcapsule permits glucose penetration into the core space and GOD reaction proceeds. However, when P-NIPAM-co-AA gates are hydrophobic at low pH value, this microcapsule forbids glucose penetration and GOD reaction will not occur. The accuracy of this concept was examined.

  • Research Products

    (13 results)

All 2006 2005

All Journal Article (13 results)

  • [Journal Article] Controlled release of model drugs through a molecular recognition ion gating membrane in response to a specific ionsignal2006

    • Author(s)
      T.Ito, T.Yamaguchi
    • Journal Title

      Langmuir (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] An autonomous phasetransition-complexation/decomplexation polymer system with a molecular recognition property2006

    • Author(s)
      T.Yamaguchi, et al.
    • Journal Title

      Macromolecules (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Controlled release of model drugs through a molecular recognition ion gating membrane in response to a specific ion signa2006

    • Author(s)
      T.Ito, T.Yamaguchi
    • Journal Title

      Langmuir (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The effect of pore surface modification of an inorganic substrate on the plasma grafting behavior of pore-filling-type organic/inorganic composite membranes2005

    • Author(s)
      T.Yamaguchi, et al.
    • Journal Title

      J. Polym. Sci. Polym. Chem. Ed 44(2)

      Pages: 846-856

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Molecular Recognition Gating Membranes Made by Plasma-Graft Polymerization2005

    • Author(s)
      K.Akamatsu, T.Yamaguchi
    • Journal Title

      J. Photopolym. Sci Technol 18(2)

      Pages: 229-232

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Development of a regenerable cell culture system that senses and releases dead cells2005

    • Author(s)
      T.Yamaguchi, et al.
    • Journal Title

      Langmuir 21(9)

      Pages: 4043-4049

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Role of vacuum ultraviolet irradiation in plasma-induced graft polymerization in the pore-filling polymerization of porousmaterials2005

    • Author(s)
      T.Yamaguchi, et al.
    • Journal Title

      J. Polym. Sci. Polym. Chem. Ed 43(10)

      Pages: 2068-2074

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 「バイオシステムから発想した分子認識機能膜のシステム設計」"Systematic material design for bio-system inspired molecular recognition membranes"2005

    • Author(s)
      山口 猛央ら
    • Journal Title

      膜 30(3)

      Pages: 124-131

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] An autonomous phase transition-complexation/decomplexation polymer system with a molecular recognition property2005

    • Author(s)
      T.Yamaguchi, et al.
    • Journal Title

      Macromolecules (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The effect of pore surface modification of an inorganic substrate on the plasma grafting behavior of pore-filling-type organic/inorganic composite membranes2005

    • Author(s)
      T.Yamaguchi, et al.
    • Journal Title

      J.Polym.Sci.Polym.Chem.Ed 44(2)

      Pages: 846-856

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The effect of pore surface modification of an inorganic substrate on the plasma grafting behavior of pore-filling-type organic/inorganic composite membranes2005

    • Author(s)
      T.Yamaguchi, et al.
    • Journal Title

      J.Polym.Sci.Polym.Chem.Ed 18(2)

      Pages: 229-232

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Role of vacuum ultraviolet irradiation in plasma-induced graft polymerization in the pore-filling polymerization of porous materials2005

    • Author(s)
      T.Yamaguchi, et al.
    • Journal Title

      J.Polym.Sci.Polym.Chem.Ed. 43(10)

      Pages: 2068-2074

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Systematic material design for bio-system inspired molecular recognition membranes2005

    • Author(s)
      T.Yamaguchi, et al.
    • Journal Title

      Membrane 30(3)

      Pages: 124-131

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2007-12-13  

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